[Walter Stoeckel--his life and work].
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Biomedical subjects
Publications and source records attributed to H Bayer.
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Starting point of this survey is the 1954 paper about obstetrical operations from H. Kraatz. It is demonstrated, that there were and there are defined principles, which continue to exist unchanged. They are the fundamentals of indication and technique of operations in obstetrics. Nevertheless there are distinct changes, too, caused by two factors, progress in medicine (development of antibiotics, anaesthesiology and neonatology) as well as change of aspect in obstetrics (e.g. toxemias of pregnancy, preterm labour). The methods are discussed in detail. Operations by vaginal route come in the foreground in the last years more again. They should be preferred in maternal interest. The enlarged indication for caesarean section was not able to succeed on a large scale. An uniform procedure is proposed both in cephalic and breech presentation, and the new formulated preconditions to these operations are discussed. All three techniques two abdominal ones and one vaginal one) are demanded in caesarean sections, because they come into question in special situations. There is a change in operative indications in cases of bleeding, because of an early diagnosis by ultrasound. The qualification and experience of the obstetrician is more decisive than the selected method of operation or the instrument's type. Therefore there should not be any cut in instruction and training. The versatility of operative technique is a prerequisite to a qualified indication.
Analysing cardiotocographs not only fetal heart frequency and uterine contractions but also fetal movements have to be considered. Based on this knowledge 96 cardiotocographs are estimated with simultaneous observation by ultrasound. It seems to be possible to conclude from the tocograph pattern to the type of movements.
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The isolated paralysis of the dorsal erector trunci in the angular point of the convex curve of a juvenile scoliosis in progress by resecting the corresponding rami dorsales of the spinal nerves gave the opportunity to analyse electromyographically with electrodes on the skin before and after the operation in the two basic positions: standing comfortably upright and bending the trunc with extended arms. Thus the electric activity of the erector trunci could be isolated from the total activity of all the measured dorsal muscles. The pre-operative hyperactivity of the erector trunci on the convex side in the protogenic curve increases unproportionally strongly when the trunk is bent, trunk bending regarded as an example for a symmetric exertion. This pre-operative hyperactivity is eliminated by the operation which denervates the erector trunci.
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On the base of actual knowledge about ultrasound diagnosis in obstetrics some questions with regard to contents and organisations of complete pregnant women care must be answered. It is attempted to show ultrasound diagnosis to be a durable part of obstetric care and to be a component part of routine examination. In this way some conventional examination methods can be cancelled or carried out in a better form. Through that obstetric care can be increased to a higher niveau.
Sodium nitroprusside (Nipride) was used in 35 patients between 16 and 72 years for induced hypotension. The fast and dose-dependent effect on the smooth muscles of the vessels made it superior to other methods of lowering blood pressure. Sodium nitroprusside was used to achieve hypotension in 11 patients (group I) with an aneurysm of a cerebral vessel and in 16 patients (group II) with highly vascularized cerebral tumors. In 8 patients (group III) from the neurosurgical intensive care unit a hypertensive crisis was interrupted. 10 patients (group IV) without induced hypotension were used as controls to compare the action of our standardized method of anesthesia on the observed parameters of blood pressure lowering. The average dose of sodium nitroprusside was 2.74 mcg/kg/min. in group I, 1.77 mcg/kg/min in group II and 1.27 mcg/kg/min in group III. The initial blood pressure was lowered between 30--40% in the mean in all 3 groups. Careful monitoring of the intra-arterial blood pressure, the central venous pressure, the cerebral fluid pressure, the arterial blood gases and the function of the kidneys during and after induced hypotension with sodium nitroprusside made it possible to take advantage of the blood pressure lowering effect also in patients with increased intracranial pressure.
Sodium Nitroprusside (Nipride) was administered by infusion pump intravenously in 27 neurosurgical patients for intraoperative, postoperative and posttraumatic blood pressure lowering. This was accomplished with intension to reduce the risk of hemorrhage during operation on highly vascularized tumors or aneurysms and to combat hypertensive crisis after surgery and brain injury. The effect was documented by direct arterial blood pressure registration and the drug proved to be fast acting, potent and readily reversible. Dosage varied between 1 and 10 microgram/kg/min with systolic pressure decreasing about 6 to 60% of the initial value. There was ill correlation between infusion rate and blood pressure drop which demanded particular caution at the beginning and the end of infusion. A decrease in pulse pressure and a moderate tachycardia were generally observed, however no complications were seen due to a Sodium Nitroprusside administration over less than 12 hours duration in our series.
The starting point of this paper are works from H. Kraatz, written in 1958 and 1960 about history and future and propositions of the Hospital. It could be shown nearly all the plans of Kraatz to be realized during the following years. Under preserve of the traditions the modern development of science leaded to the present works astructure of the clinic. Some results are published to give reasons for this.
This paper explains the momentary situation of diseasediagnostic with ultrasonic (B-scan). Possibilities and limits of this methods are shown. Some rare symptoms fetal-disease are explained and we discuss the possibility, to recognize diseases of skeleton and central nervous system better than before.
After a short representation of the present possibilities in prophylaxis and therapy of premature infants an information is given about disturbances of metabolism of the liver follow up the treatment with beta-adrenergic substances. Further a first report is given about laying in of pessars in addition to cerclage in cases of insufficiency of the cervix uteri.
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Gravidity and the intracranial process are discussed in view of the question of whether to carry out an interruption of pregnancy or to carry the pregnancy to full term and end it by means of Cesarean section, on the basis of literature and 5 observations.--It is recommended to work out an individual plan of treatment together with the obstetrician and the neurologist. It was shown that there is a possibility of an operative treatment of intracranial processes of different genesis even in the advanced stage of pregnancy and with the continuation pregnancy.
A thin layer chromatographic method for the specific determination of estriol-16-glucoronide as azo dye is described. With this simple method the estriol excretion during pregnancy can be determined with omission of several steps in the determination such as the hydrolysis or evaporation of solvents. A single determination including the thin layer chromatography takes approximately 40 minutes. Based on 210 single determinations from the urine of pregnant women the normal range of excretion between the 28-42 week of pregnancy is determined. The mean excretion rises from 10.8 mg/24 hours at 28 weeks gestation to 25.8 mg/24 hours at 41 weeks gestation. The excretion of estriol-16-glucoronide is a measure of the estriol synthesis in the fetal-placental unit.
At first the allround etiology of premature birth is explained in the paper. There are to distinguish three groups: 1. Causes with known etiologic mechanism. 2. Causes with partly known etiologic mechanism. 3. Dispositions for premature birth. These are concluded from statistically investigations. In the last group are collected the patients from which are established some known scores for diagnosis of the risk of premature birth. All the scores but have a detriment. If they want to detect about 90% from premature births one must carry out examination and observation about 40% from all pregnant women. For this the scores are not suitable for selection of patients to observe in a special consultation. The organised care for pregnant women must be in such a way that all the criterias of imminent prematurity will be detected. This way has been successfull in our hospital.
The therapy of imminent prematurity needs specific treatment of the respective illness. Moreover there are three fundamental measures: 1. To appease the patients and to applicate sedatives. 2. To carry out tokolysis with medicamentes. 3. To carry out cerclage operation in order to close the uterine mouth. These possibilities must be combined in various ways dependent from the success in every individual case. These measures also are suit in prophylaxis, for example in disorders of former pregnancies. All schemes of therapy adapted to the individual case. The dosis must be determined from the effect of therapy. A particular view point must be the hospitalisation between 28. and 32. week of pregnancy in cases of twins or placenta previa. Also in cases of early rupture of amnion prolongation of pregnancy must be aspired.