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Biomedical subjects

H Bartels

Publications and source records attributed to H Bartels.

At least 163 records · Page 9Linked to original sources
PubMed1987

[Treatment guidelines in intestinal burns].

Intestinal burns due to ingestion of acids or alkaline materials still put the physician in a difficult position because until now it is not possible to correlate the amount of ingested material to the extent of damage that can be expected. Furthermore, there are no objective criteria to determine the depth of the burn. Diagnosis is based on endoscopy. Mild, moderate and severe damage can be differentiated endoscopically. Mild and moderate burns are not operated upon primarily. Surgery is indicated with moderate burns whenever complications occur during intensive care treatment, and generally with severe corrosive burns. Operative management depends on intraoperative findings.

Burns, Chemical↗
PubMed1986

[Esophageal carcinoma: transthoracic esophagectomy with regional lymphadenectomy and reconstruction with deferred priority].

In a retrospective analysis the risks were assessed of transthoracic oesophagectomy with mediastinectomy and regional lymphadenectomy followed 48-72 hours later by an abdomino-cervical operation with supra-pancreatic lymphadenectomy, retrosternal gastric interposition and cervical oesophageal stump anastomosis. Results in this group of 37 patients were compared with those in a group of 42 patients who had undergone a transmediastinal oesophagectomy (without thoracotomy) and immediate reconstruction. The 30-day death rate was 8.1% in the former (group I) and 7.1% in the latter (group II), total hospital death rate 10.8% and 11.9%, respectively. The complication rate was similar in the two groups, as was the recorded operative stress. The results indicate that the risk of an oncologically indicated oesophagectomy with regional lymphadenectomy is no greater than that of a palliative transmediastinal oesophagectomy.

Adenocarcinoma↗
PubMed1986

[The significance of nephrosonography for the early recognition of kidney tumors].

In the following presentation the criteria of solid kidney tumours and their differential diagnosis are demonstrated. 175 patients operated upon since 1976 demonstrate the significance of ultrasonography for early detection of kidney tumours. The results show that early detection of kidney tumours is possible by nephrosonography; an early and simple operation can be performed and improves prognosis dramatically.

Abscess↗
PubMed1986

[Clinical and prognostic relevance of the Kiel classification of non-Hodgkin lymphomas].

The Kiel classification provides a new subdivision of non-Hodgkin lymphomas into distinct entities showing different clinical and prognostic properties. In comparison with earlier classifications this system defines additional types of lymphoma (e.g. CC lymphoma, LP immunocytoma) (for abbreviations see text) which are to be considered separate entities also from a clinical point of view. By data derived from a multicenter prospective observation study (1,127 patients recruited from 1975 to 1980, follow-up until 1985) a precise definition of the clinical features of each lymphoma entity (e.g. frequency, age and sex distribution, patterns of initial involvement and spread of disease) was possible. In addition, the effect of radio- and/or chemotherapeutic measures was evaluated. Strictly localized disease (stage I/IE according to the Ann Arbor classification) occurred in 1.5 to 8% of patients with NHL of low-grade malignancy (comprising 69.4% of cases studied) and in 8 to 17% of patients with high-grade malignant NHL (comprising 30.2% of cases studied). Loco-regional irradiation alone was able to induce complete remission in 86 to 89% (CB and IB lymphomas) and in 100% (LP immunocytoma, CB-CC and CC lymphomas), respectively, of stage I/IE patients. Only CC and IB lymphomas showed a relevant risk of relapse (40% and 50%, respectively). Total lymphoid irradiation as able to induce stable complete remissions in about 50% of patients with stage III of CB-CC lymphoma. Probabilities of survival of patients with initial stages III and IV treated by several types of chemotherapy reflect different prognostic features of individual lymphoma entities.(ABSTRACT TRUNCATED AT 250 WORDS)

Combined Modality Therapy↗
PubMed1986

In vitro activity of the new quinoline derivative ciprofloxacin alone and in combination against various Mycobacterium-, Salmonella- and Escherichia coli strains.

The antibacterial effect of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazine-1-ylquinoline++ + 3-carboxylic acid (ciprofloxacin, Bay o 9867) has been tested using different test systems and various strains, especially of Escherichia coli, Mycobacterium and Salmonella. Ciprofloxacin shows low MIC's against most of the tested strains. The high in vitro and in vivo activity against Salmonella is most promising for cure of salmonellosis.

Anti-Bacterial Agents↗
PubMed1986

Orthogonal arrays of particles in the plasma membrane of pneumocytes.

The presence of orthogonal arrays of particles (OAP) in pneumocytic membranes was studied using freeze-fracture replicas of lung tissue from turtles, frogs and various mammalian species, including man. OAP are typically present in the basal plasma membrane of pneumocytes in turtles and frogs, while they have only been detected in the plasma membrane of type I cells in human lungs among the mammalian species studied. The median of particles per OAP was 10 (range 4-40) in lower vertebrates and 8 (range 4-24) in man. The mean density of OAP per unit cell surface varied between 40 and 60/micron2. The frequent occurrence of OAP in pneumocytic membranes in the lungs of man, turtles, and frogs suggests that they are related to a specific, although undetermined pulmonary function which is restricted to the ciliated airway epithelium in those mammalian species lacking OAP in the alveolar epithelium.

Animals↗
PubMed1985

Assemblies of linear arrays of particles in the apical plasma membrane of mitochondria-rich cells in the gill epithelium of the Atlantic hagfish (Myxine glutinosa).

In the gill epithelium of the Atlantic hagfish Myxine glutinosa a mitochondria-rich cell type is described which ultrastructurally resembles the chloride cells in other fish species. Freeze-fracture replicas reveal different supramolecular structures in the luminal plasma membrane and in the intracellular amplification (tubular system) of the basolateral plasma membrane of these mitochondria-rich cells. In the luminal plasma membrane ordered assemblies of particles and fibril-like elements are regularly found. On the P face, the assemblies are composed of up to 20 linear arrays of particles which are preferentially located in the microvillar membrane on which they show a helicoidal orientation. The arrays are formed by globular (diameter 8-9 nm) and rod-shaped (length 16-20 nm) particles, which occasionally are so tightly end-to-end attached that they generate fibril-like structures. The distances between adjacent arrays within an assembly measure 10-15 nm. On the E face complementary patterns of linear grooves are present. These assemblies have not previously been demonstrated in the freeze-fractured plasma membrane of branchial chloride cells. In the membrane of the tubular system, emerging from the basolateral plasma membrane of the mitochondria-rich cells, infrequently repeating rows of 7-8 nm particles are present in addition to randomly distributed globular particles (diameter 7-8 nm). Complementary patterns of grooves are present on the E face. These intramembranous structures resemble the repetitive elements which have been previously described in the tubular system of branchial chloride cells in euryhaline teleosts and the subunits of which are considered to be the sites of ion pumps.

Animals↗
PubMed1985

The significance of the number of centroblasts in centroblastic/centrocytic lymphomas. A long term study in a large group of patients.

A group of 385 centroblastic/centrocytic lymphomas with long follow-up periods was subdivided on the basis of the relative number of centroblasts in the initial biopsies. Only minor differences in overall survival were found although a different survival pattern was observed between the groups. The transition into a high-grade malignant secondary centroblastic lymphoma correlated, at a statistically significant level, with the relative number of centroblasts in the initial biopsy.

Actuarial Analysis↗
PubMed1985

[Fiberoptic bronchoscopy in intensive care medicine--functional efficacy and methodological side effects].

A prospective study was performed to determine the side effects of fiberoptic bronchoscopy on cardiopulmonary function, the influence of bronchial lavage on cardiopulmonary function, and the functional efficacy of fiberoptic bronchoscopy in obstructive atelectasis due to retained secretions. In 17 patients endotracheal intubation was immediately followed by a significant (P less than 0.01) rise in arterial, pulmonary artery and pulmonary capillary wedge pressure, heart rate, and cardiac output. There were no statistically significant differences in arterial blood gases and intrapulmonary right-to-left shunt. Two patients showed circulatory changes indicative of a heart insufficiency on the left side. A significant increase (P less than 0.001) in intrapulmonary right-to-left shunt from 12% to 17.5%, a significant decline in arterial oxygen tension of 15 mm Hg, and a significant increase of cardiac output from 6.4 to 7.71/min following saline solution lavage (20 ml in each bronchus) were observed in nine patients. The results indicate that bronchial lavage is the essential mechanism for the decline in arterial oxygen tension induced by fiberoptic bronchoscopy. In patients with unstable cardiopulmonary status, the cardiovascular response during bronchoscopy may be hazardous and the bronchoscopist should be aware of the pathophysiologic side effects involved. Fifteen therapeutic bronchoscopies were performed in five critically ill patients with obstructive atelectasis, due to retained secretions. Following the procedure, Qs/Qt declined from 23.9% to 15%, cardiac output from 9.3 to 7.31/min, and arterial Po2 increased from 58.9 to 70.9 mm Hg. The differences were statistically significant (P less than 0.0001). The therapeutic value of fiberoptic bronchoscopy in the treatment of obstructive atelectasis is demonstrated by the significant improvement in cardiopulmonary status.

Arrhythmias, Cardiac↗
PubMed1985

Cellular hyperplasia and hypertrophy, capillary proliferation and myoglobin concentration in the heart of newborn and adult rats at high altitude.

Newborn rats and their mothers were subjected to a simulated altitude of 5000 m for 4-5 weeks. Weight, capillary density (CD), fiber cross-sectional area (AF) and capillary-to-fiber ratio (C/F) of right (RV) and left (LV) ventricles and myocardial myoglobin (Mb) concentration were measured weekly in the newborns and at the end of the high altitude sojourn in the adults. Results were compared to sea level controls. In the adults, adaptive changes were only observed in the right ventricle. In newborns both, RV and LV, exhibited significant alterations. After 2 weeks at 5000 m the ventricular weight increase was 223% (RV) and 40% (LV) in the newborns and 96% in the adults' RV. Whereas only fiber hypertrophy was detectable in the RV of the dams, cardiac weight increase of the acclimatized neonates resulted from both, hypertrophy and hyperplasia of the myocytes. Appropriate capillary proliferation kept CD constant. Cardiac Mb concentration did not change. We conclude, that capillary neoformation primarily counteracts the increase of the O2 diffusion distance due to fiber hypertrophy and/or hyperplasia.

Altitude↗
PubMed1985

Aclarubicin (aclacinomycin A) in the treatment of relapsing acute leukaemias.

Forty patients with relapsing acute leukaemias were treated with aclacinomycin A (aclarubicin, ACM), 25 mg/m2 i.v. daily for 7 days. Twenty-nine patients with acute myeloid (AML) and five with acute lymphoblastic (ALL) leukaemia were evaluable. The overall response rate was 29.5%. Eight complete (CR) and one partial (PR) remissions were achieved in AML (31%). A high CR rate was induced in patients treated at first relapse without prior reinduction (6/12 patients). A small proportion of leukaemias resistant to daunorubicin or doxorubicin responded to ACM (3/17 patients). Median remission duration was 5.5 months (range: 2-9 months). The most common toxic effects were nausea, vomiting, stomatitis and diarrhoea. Acute cardiotoxic effects were documented in three patients. Congestive cardiomyopathy was not observed despite prior treatment with anthracyclines. We conclude that the present dose scheduling of ACM is effective in the treatment of relapsing AML and that it should be introduced in combined chemotherapy in phase III trials to compare its activity to that of daunorubicin or doxorubicin.

Aclarubicin↗
PubMed1985

Biological parameters in Japanese quail genetically selected for resistance or sensitivity to an acute hypoxic survival.

Various biological parameters were measured in two strains of Japanese quail selected for their resistance (Ls+) or susceptibility (Ls-) to an acute normobaric hypoxic challenge. Adults of these two strains showed very little or no significant differences concerning body weights, carbon dioxide emission, photoperiodic (L----D and D----L) respiratory reactions, cloacal temperatures, heart rates and ECG QRSII amplitudes, red blood cell data, hemoglobin electrophoresis, and plasma corticosterone (before and after an hypoxic challenge). Enzymatic capacities of phosphofructo-and pyruvate kinases, of glucose-6-phosphatase, lactico- and malate-dehydrogenases, measured in brains and hearts, showed but few statistically significant differences. Changing societal contacts did not suppress the differences of acute hypoxic survival between the two strains. Several statistically significant differences which concern reproduction and eggs, and especially egg laying and egg water vapor conductance were noted between the two strains.

Animals↗
PubMed1984

[Quality control of the self-measurement of blood sugar in unselected type I diabetics. The importance of patient training].

Unselected type I diabetics were hospitalized for group training and treatment programme during which blood-sugar was self-monitored with the Haemo-Glukotest 20-800; quality of self-monitoring improved appropriately. The patients had taken part in either the standard training programme (67 patients) or in the "intensive" training programme (101 patients). At the beginning of the training week, after the first theoretical and practical instructions, the quality of blood-sugar self-monitoring was equally poor among patients of both programmes. At the end of the "standard" training week, self-monitoring results were still unsatisfactory, though slightly better than at the onset. Because of these poor results, the training programme was intensified. Optimal quality of self-monitoring was then achieved at the end of the training period. In 69 others, also unselected, type I diabetics the quality of self-monitoring was determined 14 months after their participation in the training programme. Using the Haemo-Glukotest 20-800 (57 patients), self-monitoring gave excellent results; using a blood-glucose measuring instrument (12 patients) it was slightly worse. Assuming intensive training, even unselected type I diabetics can obtain accurate blood-sugar measurements using test-strips.

Adult↗
PubMed1984

[Clinical aspects and therapy of anaplastic T-zone lymphoma].

Between 1 January 1975 and 30 June 1983 four anaplastic T-cell lymphomas (1.1%) were observed among 368 non-Hodgkin lymphomas. The median age was 61.5 years (range 33 and 76 years). Males and females were equally affected. At the time of diagnosis stage IIIM- was seen in three cases and stage IVM+ in one case. In three of the four patients a marked B-symptomatology was noted. The median Karnofsky index was below 50%. Due to cardiac failure two patients were treated with combined cyclophosphamide, vincristine, procarbazine and prednisone and a lasting complete remission was achieved in both cases. The two other patients were treated with combined bleomycin, adriamycin, cyclophosphamide, vincristine and prednisone due to rapid progression. Lasting complete remissions were seen in the same manner. The median survival time is 42+ months, the Karnofsky index 100%.

Alopecia↗
PubMed1984

Freeze-fracture study of the turtle lung. 2. Rod-shaped particles in the plasma membrane of a mitochondria-rich pneumocyte in Pseudemys (Chrysemys) scripta.

In thin sections of the lung of the fresh-water turtle Pseudemys (Chrysemys) scripta some pneumocytes can be distinguished from the remaining pulmonary epithelial cells by a larger amount of mitochondria. In these cells the typical features of type-I and type-II cells are absent. Freeze-fracture replicas reveal rod-shaped particles in the apical plasma membrane of a small population of pneumocytes, which by cytological criteria seem to be identical with the mitochondria-rich cells observed in thin sections. It is assumed that these cells represent a distinct type of pneumocytes in the turtle lung and that they are a member of the group of mitochondria-rich cells present in some ion-transporting epithelia. The function of these cells in this location remains to be determined.

Animals↗
PubMed1984

Parathyroid function in different stages of vitamin D deficiency rickets.

Direct measurements of parathyroid activity are available in only small numbers of children with vitamin D deficiency rickets (VDR). Therefore serum immunoreactive parathyroid hormone (iPTH) and the urinary cyclic adenosine-3',5'-monophosphate excretion (UcAMP) were measured together with other important indices of calcium metabolism in 24 patients (aged 2-42 months) with VDR before vitamin D treatment. iPTH and UcAMP were significantly elevated in comparison to age-matched controls. In patients there was a highly significant positive correlation between iPTH and UcAMP and a negative relationship between both indices of parathyroid activity to serum phosphate and urine calcium, respectively, indicating that the simple measurement of serum phosphate and/or urine cAMP and Ca provides a reliable tool for the assessment of secondary hyperparathyroidism in VDR. In two patients classified as being in the early stage of VDR the parathyroid activity was not elevated despite hypocalcemia indicating relative hypoparathyroidism. Twelve patients with VDR were followed during vitamin D therapy: Within the first 2 weeks of treatment UcAMP slightly increased and thereafter decreased in most patients, but was still elevated in three patients even after 7 weeks, whereas iPTH became normal within 3 weeks of treatment. This favors the concept that vitamin D deficiency diminishes the activation of renal adenylate cyclase by PTH which is overcome by the highly increased PTH secretion in the advanced stages of rickets. The basal and calcium-stimulated serum calcitonin (CT) levels, determined in some of the patients, were normal, ruling out a significant disturbance of CT secretion in VDR.

Calcitonin↗