[Needle biopsy in thyroid diseases].
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Biomedical subjects
Publications and source records attributed to H Bank.
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Yersinia enterocolitica agglutinating antibodies were present in 42% of 36 patients with thyroid disease and in none of 77 control subjects. Since the frequency of Yersinia infections in Israel is low, the association of thyroid diseases with Yersinia antibodies is of particular interest. The significance of this finding is discussed in view of some recent observations.
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The etiologic, bacteriological, clinical and therapeutic aspects of 95 cases of bacterial or fungal meningitis in adults seen in a large community hospital were reviewed. The study was limited to non-neurosurgical patients in whom positive cerebrospinal fluid cultures were obtained. Overall mortality was 40%, with no appreciable change during the 22-year period. The most common causative organism was the pneumococcus, with a 45% mortality. There were no deaths among the patients with meningococcal meningitis. Cryptococcus neoformans was the third most common single organism encountered. Meningitis due to uncommon organisms usually developed in debilitated or immunologically compromised patients, and had a poor prognosis. Advanced age, underlying debilitating disease and severly impaired consciousness on admission were associated with a high mortality. Bacterial and fungal meningitis in adults remains a serious life-threatening disease, despite advances in antibiotic therapy.
Nonciliated bronchiolar epithelial (Clara) cells are selectively damaged by intraperitoneal administration of naphthalene. We examined these changes using light microscopy, transmission electron microscopy, and scanning electron microscopy. Naphthalene administration causes the Clara cells to expand and exfoliated shortly thereafter. Following exfoliation the remaining ciliated cells show morphologic abnormalities, including cilia loss and ballooning of remaining cilia. Upon regeneration of the Clara cells the ciliated cells gradually return to their normal appearance. One possible explanation for these findings is that the Clara cell secretions directly affect the physiologic state of the surrounding ciliated cells.
A simple resistive heating electrode has been designed for use in metallic replication procedures. The electrodes are relatively small, reliable, adaptable to most vacuum systems, and are compatible with ultra-high vacuums. They are easily aligned, have good electrical conductivity and ajustable tensions. Using these electrodes with full wave rectified a.c., we found reduced specimen heating, lower background granularity, and improved resolution compared to commercially available designs.
An unusual association of pancarditis due to Streptococcus viridans is described. The pathologic findings appear to indicate that the myocardial infection and pericarditis were blood borne.
An accurate, highly sensitive triiodothyrone (T3) radioimmunoassay system is described. Direct measurement in serum is made possible by the use of T3-free serum for standards, and blocking of T3 binding to thyroxine (T4)-binding globulin with salicylate. T4 cross reactivity was less than 0.3%. Mean T3 levels in 55 euthyroid, 32 hyperthyroid and 19 primary hypothyroid patients were 1.46 +/- 0.17, 5.34 +/- 1.86 and 0.49 +/- 0.34 (SD) ng/ml, respectively. T3 was found to be a more sensitive index than T4 in hyperthyroidism; in hypothyroidism it overlapped with euthyroidism. The presence of goiter had no effect on T3 concentrations in euthyroid patients. Among the patients studied, eight were found to have T3 toxicosis, including two patients with recurrent thyrotoxicosis. A significant T3 elevation was also found in euthyroid patients after thyroidectomy whereas T4 remained normal. The extent of T4 and T3 elevation was similar during the initial phase of subacute thyroiditis. There were significantly lower T3 values and higher thyroid-stimulating hormone values in umbilical cord blood than in maternal blood. In two euthyroid subjects, thyrotropin-releasing hormone stimulation caused a 50% rise in T3 levels and no change in T4 levels over a 2-h period.
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