Biomedical subjects

H Baba

Publications and source records attributed to H Baba.

At least 361 records · Page 20Linked to original sources

PubMed1990

Long survival of a woman with a huge leiomyosarcoma of the duodenum after pancreaticoduodenectomy and transverse colectomy: a case report.

A woman with a huge leiomyosarcoma of the duodenum that had invaded the pancreas and transverse colon is living and well 10 years after pancreaticoduodenectomy combined with resection of the transverse colon. Malignant potential of the tumor was determined by the mitotic rate and nuclear deoxyribonucleic acid content. The mass exceeded 10 cm yet was characterized by low mitotic activity and a near-diploid pattern. The long survival is attributed to the extensive surgery and low-grade malignancy of the tumor.

DNA, Neoplasm↗

PubMed1990

[Prevention of peritoneal recurrence by combined intra-peritoneal and intra-tumoral injections of OK-432].

Protective effect of OK-432 on peritoneal recurrence was examined in an experimental mouse model with Meth A fibrosarcoma injected into both abdominal wall and intraperitoneal cavity. OK-432 was given through either intratumoral (i.t.), intradermal (i.d.), intraperitoneal (i.p.), or i.p. + i.t. route. A significant antitumor effect against abdominal tumor was observed in mice given i.t. or i.p. + i.t. injection of OK-432. A significant protective effect against peritoneal recurrence and prolonged survival time was obtained in an i.p. + i.t. group, although other treatment groups showed only minimal effect. We conclude that combined i.p. and i.t. administration of OK-432 may prevent peritoneal recurrence and lead to prolongation in clinical patients with advanced GI tract cancer.

Animals↗

PubMed1989

Width of serosal invasion and prognosis in advanced human gastric cancer with special reference to the mode of tumor invasion.

We studied the influence of the width of serosal invasion on the prognosis, in relation to the mode of invasion, in 142 patients who had curative resection for gastric carcinoma that invaded beyond the muscularis propria. The mode of invasion was classified into infiltrative and expanding types. Average diameter of tumor at the serosal or subserosal layer for the infiltrative type was 4.2 +/- 3.2 cm, a value significantly greater than that of 2.5 +/- 2.0 cm for the expanding type (P less than 0.01). The 5-year survival rate of patients with the infiltrative type carcinoma was significantly lower (36.8%) than that with the expanding type carcinoma (50.0%) (P less than 0.05). In the infiltrative type, the survival time of patients with a serosal invasion exceeding 2 cm was significantly shorter than when the serosal invasion was less than 2 cm (P less than 0.05). In the expanding type, however, the prognosis was good until the width of serosal invasion extended to 4 cm or greater. The difference in survival according to the width of serosal invasion did not always depend on the incidence of positive lymph nodes in both types of carcinomas. Therefore, influence of the width of serosal invasion on the prognosis for advanced gastric carcinomas differs between infiltrative and expanding types.

Female↗

PubMed1989

Increased therapeutic gain of combined cis-diamminedichloroplatinum (II) and whole body hyperthermia therapy by optimal heat/drug scheduling.

To maximize therapeutic gain, the timing sequence of whole body hyperthermia (WBH) and cis-diamminedichloroplatinum (II) (DDP) was examined. Normal tissue injury as well as growth of a s.c. transplanted fibrosarcoma were measured in F344 rats treated with variable schedules of WBH and DDP. Simultaneous application of DDP (2 mg/kg i.v.) with WBH (120 min at 41.5 degrees C) resulted in severe renal injury, body weight loss, and mortality; while sequential use of the modalities caused minimal to no toxicity. DDP or WBH alone produced only minimal tumor growth delay, whereas supraadditive antitumor effects occurred with all tested schedules of DDP combined with WBH, regardless of sequence or interval between the two modalities. We designated the ratio of antitumor effect to nephrotoxicity as specific therapeutic efficacy (STE). DDP given simultaneously with WBH produced the lowest STE (0.6-1.2), which was less than or equal to either DDP (STE = 1.2) or WBH (STE = 1.5) alone. On the other hand, schedules of DDP prior to and after WBH resulted in a STE of 1.8-3.0, a supraadditive effect. These results indicate that an optimal scheduling of DDP with WBH significantly improves therapeutic gain by reducing normal tissue injury while maintaining enhanced antitumor activity.

Animals↗

PubMed1989

[Angiographic positions for thoracic outlet syndrome].

Thirty four patients (18 males and 16 females, 54 lesions) with thoracic outlet syndrome (TOS) were studied with conventional angiography. Angiography in the supine position did not confirm subclavian artery compression in 43.4% of patients. Lordotic position or upright position was useful for demonstration of subclavian artery compression in patients who did not show any findings in conventional techniques.

Adolescent↗

PubMed1989

Prognostic significance of DNA content with special reference to age in gastric cancer.

The authors studied 93 patients who had undergone curative resection for advanced gastric cancer to assess the prognostic significance of DNA ploidy in relation to patient age. The cancers were classified as low and high-ploidy carcinomas and the patients were grouped by age (22-44 years, 45-64 years, 65-79 years). The incidence of high ploidy cancers increased with age. The 5-year survival rate increased with patient age in the low ploidy group whereas it decreased with patient age in the high ploidy group. There was a statistically significant difference (P less than 0.05) in the 5-year survival between our oldest patients with low (100%) and high ploidy (25.7%) gastric cancer. High ploidy cancers manifested a higher incidence of vessel invasion and lymph node metastasis. Our findings indicate that analysis of the DNA distribution pattern in gastric carcinoma is of prognostic value especially in older patients.

Adult↗

PubMed1989

Reactive changes in the esophageal epithelium and predictability of survival for patients with adenocarcinoma of the upper third of the stomach.

In 93 patients with an adenocarcinoma in the upper third of the stomach and involving the lower esophagus, the authors examined the histopathologic changes of the esophageal epithelium at the involved lesion, and the prognosis. Changes in the esophageal epithelium were histologically divided into four groups: hyperplastic (34 cases), atrophic (26 cases), hyperplastic and atrophic (mixed, 20 cases), and no change (13 cases) types. The hyperplastic type was closely related with the expanding mode of invasion and depth of the invasion was less than seen with the atrophic type (P less than 0.05). The rate was significantly higher in cases of a curative resection and the outcome was better than seen with the other types (P less than 0.01-0.001). The atrophic type was related with Borrmann type IV of the gross type and infiltrative mode of invasion, and had a significantly longer length of esophageal invasion than did the hyperplastic and the no change types (P less than 0.01). The prognosis was significantly poorer than seen with the hyperplastic (P less than 0.001) or the mixed types (P less than 0.01). Our study shows that histopathologic changes in the esophageal epithelium provide the surgeon with useful prognostic indicators in cases of an adenocarcinoma in the upper third of the stomach and involving the lower esophagus.

Adenocarcinoma↗

PubMed1989

DNA ploidy and tumor invasion in human gastric cancer. Histopathologic differentiation.

The relationship between DNA ploidy and tumor invasion in 254 patients with gastric carcinoma was studied, with particular emphasis on histopathologic features. In the differentiated type of adenocarcinoma, there were aneuploid lesions characterized by a relatively high incidence of lymph node metastasis and hematogenous recurrence, even when the invasion was limited to the submucosa. In the undifferentiated type, aneuploid lesions were rarely seen at the early stage, but the frequency remarkably increased with invasion into the deeper layers. Nodal involvement and disseminating metastasis were evident with serosal invasion. Analyzed by a multivariate Cox model, DNA ploidy significantly correlated with prognosis. Thus, DNA ploidy is a major determinant of survival, and the behavior of an aneuploid carcinoma is apparently controlled by individual histologic type.

DNA, Neoplasm↗

PubMed1989

Prognostic factors in gastric cancer with serosal invasion. Univariate and multivariate analyses.

Univariate and multivariate analyses of possible prognostic factors were carried out on data from 142 patients who had undergone curative resection for a carcinoma of the stomach invading beyond the muscularis propria. In the univariate analysis, factors including age, size of cancer, gross form, depth of penetration, lymph node metastasis, lymphatic invasion, width of serosal invasion, mode of invasion, volumetric shape of invasion, and stage had an individual prognostic significance. The multivariate analyses indicated that stage, lymph node metastasis, and depth of penetration were the most significant prognostic factors and that the prognosis in cases of obvious serosal invasion, or those with secondary or tertiary nodal involvement, was poor. For such patients, we prescribe postoperative intensive chemotherapy, even when a "curative" operation is done.

Adenocarcinoma↗

PubMed1989

Hypercalcemia related to the poor prognosis of patients with squamous cell carcinoma of the esophagus.

A review of 208 cases of surgically treated squamous cell carcinoma of the esophagus revealed 16 (7.7%) with hypercalcemia. There was no evidence of bone metastases in 13 (6.3%) of the patients with hypercalcemia. Pathogenesis of this hypercalcemia without bone metastases was suggested to be multifactorial. Anastomotic leakage and malnutrition because of fasting were the most possible causes of mild hypercalcemia, and moderate to severe hypercalcemia was thought to be due to subclinical and clinical recurrence of the tumor, probably with PTH-like hormonal activity. Overall survival rates in the groups with and without hypercalcemia were 18.2 and 61.7% at the 12th postoperative month and 9.1 and 37.8% at the 24th month, respectively. Thus hypercalcemia is a significant prognostic factor linked to an unfavorable clinical course even in patients with no evidence of bone metastases.

Bone Neoplasms↗

PubMed1989

Postoperative adjuvant chemotherapy inhibits early recurrence of early gastric carcinoma.

Data on 300 patients with early gastric carcinoma who underwent curative resection were analyzed for the suppressive effects of postoperative adjuvant chemotherapy on early recurrences. Retrospective grouping was done as follows: no chemotherapy (NC) group (169 patients), mitomycin C (MMC) group (108), and another group (23). In all, 24 patients (16 in the NC, 6 in the MMC, and 2 in the other group) who died of other diseases within 5 years after surgery were excluded. Therefore, data on 153 individuals in the NC and 102 in the MMC group were analyzed. The recurrence rate in patients with Pen A type carcinoma, with a propensity toward an early recurrence in the liver, was 37.5% in the NC and 9.1% in the MMC group. Among 27 Pen A type patients, 3- and 4-year survival was significantly higher in those receiving MMC (100%) than in those given NC (62.5%). Recurrences in the liver occurred in 6/14 of the NC patients within 3 years after surgery, whereas there were no recurrences in 11 MMC patients. Thus, the postoperative adjuvant chemotherapy with mitomycin-C has an inhibitory effect on early recurrence in patients with Pen A type early gastric carcinoma.

Carcinoma↗

PubMed1989

Anti-GM1 ganglioside antibodies with differing fine specificities in patients with multifocal motor neuropathy.

Antibodies to gangliosides were detected in sera from three of 19 patients with chronic inflammatory polyneuropathy (CIP) by a thin-layer chromatogram overlay technique. All three of the patients fell into a clinical subset of the group that had multifocal motor neuropathy, and in all three patients the antibodies reacted with GM1 ganglioside. However, the fine specificities of the antibodies differed as demonstrated by cross-reactivity with different gangliosides in each of the three patients. The antibodies in patient 1 reacted with GM1, GD1b, and asialo-GM1 suggesting that the terminal Gal(beta 1-3)GalNAc moiety that is common to these three glycolipids is an important part of the epitope(s). This was confirmed by showing reactivity of the antibodies with Gal(beta 1-3)GalNAc conjugated to bovine serum albumin. Patient 2 had antibodies that did not react with GD1b, but cross-reacted with GM2 ganglioside suggesting that the epitope(s) involved the inner portion of the oligosaccharide moiety that is shared between GM1 and GM2. Patient 3 had antibodies that reacted with GM1 and asialo-GM1, but they did not cross-react with either GD1b or GM2. These results provide further evidence for a relationship between motor nerve syndromes and anti-GM1 antibodies and also suggest that GM1 could be a principal target antigen since other reactive gangliosides differed among the patients. However, the possible pathogenic effects of anti-GM1 antibodies on motor nerves remain to be established.

Antibodies↗

PubMed1989

Supplementary motor area kindling in the photosensitive baboons.

Two Senegalese baboons (Papio papio) were subjected to daily electrical stimulation at the SMA. When compared with the results of kindling at different frontal cortical sites, ADT and GST at the SMA were lower than those at other sites. On the other hand, the number of stimulations required for Stage 4 asymmetrical generalization was much greater at the SMA (mean of 78.0) than that for the PMA (22.5). These findings suggest that partial seizure originating from the PMA rather than the SMA seems to have a better access to the mechanisms underlying secondarily generalized convulsive seizure despite exquisite susceptibility to AD generation at the latter.

Animals↗

PubMed1989

Total (anterior and posterior) decompression of the spinal cord: surgical treatment for combined ossification of the posterior longitudinal ligament and yellow ligament of the thoracic spine.

The ossification of the posterior longitudinal ligament (OPLL) combined with ossification of the yellow ligament (OYL) in the thoracic spine can compress the spinal cord from the anterior and posterior direction, resulting in serious myelopathy. For these cases we devised a treatment consisting of two steps, total decompression of the spinal cord. The first step is removal of ossified yellow ligament posteriorly following wide laminectomy and the second step is removal of ossified posterior longitudinal ligament anteriorly, followed by interbody fusion. As the final procedure of the first step, two parallel deep gutters, covering the complete length of the ossified ligament to be removed anteriorly, are drilled from the posterior direction into the vertebral body along both sides of the dura. This pretreatment makes removal of the ossified ligament from the anterior, during the second stage, much easier and safer. This operation appears to be a promising operative procedure from our seven case experiences so far.

Adult↗

PubMed1989

[Hypothalamic glioma with diencephalic syndrome and following precocious puberty--a case report].

A 1-year 11-month-old girl was admitted for losing her weight and gait disturbance. At 4 months of age, she began to become emaciated inspite of normal food intake. Physical and neurological examinations were normal except for a marked lack of subcutaneous fat, irritability and nystagmus. CT scans demonstrated a large tumor occupied in the third ventricle and marked dilatation of the lateral ventricles. Endocrinological studies revealed high levels of plasma growth hormone (GH) in contrast with normal levels of somatomedin-C. The basal value of GH returned to normal with a subnormal response to insulin subsequently after VP-shunt. Then, a pilocytic astrocytoma was partially resected with transcallosal approach. Postoperative course was uneventful and her growth rate returned to normal range. CT scans after radiation therapy of 49 Gy showed marked decrease in size of the tumor. At 3 years and 6 months of age, enlargement of her breast was pointed out although MRI indicated no enlargement of the tumor. Basal value of LH, FSH, E 1 and E 2 elevated and LHRH test showed over-response of LH and FSH. Other hypothalamic-pituitary functions were partially preserved. Case of precocious puberty following diencephalic syndrome associated to the hypothalamic and/or optochiasmatic glioma is quite rare in the previous literature. Mechanisms of diencephalic syndrome and following puberty are unclear. However, endocrinological and radiological findings observed in the present case suggest that hormonal disfunction might be due to the failure of inhibition on GH and LHRH secretion mechanism in the anterior hypothalamus.

Astrocytoma↗

PubMed1989

["Drop hand" resulting from cerebral infarction--case report].

A 52-year-old male was admitted with the progressive weakness of the right 3rd, 4th and 5th fingers on three days after the onset. On admission, his right hand and all of right fingers were flexed. Any extension of the right hand and any movement of right fingers were not accomplished. The sensory deficit in the right wrist joint was not observed. Initial computed tomography (CT) scan of the brain carried out on the day of admission could not detect any abnormal findings. However, the follow-up CT scans demonstrated the localized low density lesion in the left frontoparietal area. MR imaging also revealed abnormality attributable to cerebral infarction. Diagnosis of "Pseudoradial nerve palsy" was made. The mechanisms of these neurological deficits and the problems in differential diagnosis between central and peripheral nerve involvements were discussed.

Cerebral Infarction↗

PubMed1989

[Aspects of exophthalmos in relation to treatment for dysthyroid ophthalmopathy].

257 eyes of 135 patients with dysthyroid ophthalmopathy were treated with steroids and/or radiation. Steroid therapy consisted of 100-150 mg betamethasone given intravenously and orally. Radiation therapy was conducted with 1.5 Gy Lineac delivered to the retrobulbar tissue from two directions once a day for a period of 10 days. In combination therapy, the above two therapies were performed simultaneously. Exophthalmos and the new index of the c/o ratio (c/o ratio; defined as the content of the orbit divided by the capacity of the bony orbit) were measured on CT films and followed for 1 or 2 years in order to evaluate the effectiveness of these therapeutic modalities. Combination therapy yielded the best results among these therapies. Steroid therapy yielded good results for 3 or 6 months, but rebound phenomenon was recognized after a course of 1-2 year.

Adolescent↗

PubMed1989

[Extraocular muscle aspects of the treatment in dysthyroid ophthalmopathy].

The Maximum width of four rectus muscles (MR, LR, IR, SR) was measured on CT films and followed for 1-2 years in 304 eyes of 160 patients with dysthyroid ophthalmopathy. Based on these parameters, steroid therapy with 100-150 mg betamethasone, intravenously and orally, 1.5 Gy Lineac radiation therapy was given to the retrobulbar tissue from two directions repeated for 10 days and combination therapy consisting of the above two therapies given at the same time were evaluated. Combination therapy yielded the best results. Steroid therapy showed little effect on MR, but remarkable effect on SR. It was speculated that different portions of the rectus muscles may be related to different responses of rectus muscles to different treatment regimen.

Adolescent↗