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Biomedical subjects

H Baba

Publications and source records attributed to H Baba.

At least 235 records · Page 13Linked to original sources
PubMed1995

A high cervical intradural extramedullary bronchogenic cyst. Case report.

This article describes a 16-year-old male patient, otherwise healthy, with intractable suboccipital pain due to an intradural, extramedullary bronchogenic cyst at C1 level. Computed tomographic and magnetic resonance imaging scans showed an extramedullary cystic lesion on the right anterolateral side of the spinal cord at C1 level. No other vertebral, spinal cord, or cutaneous abnormality was associated. The patient underwent posterolateral resection of the C1 bony ring on the right side, followed by complete removal of a cyst microsurgically. Histology suggested that the mass, with its contents of slightly viscous and opaque liquid, was an atypical form of bronchogenic cyst with abundant pseudostratified ciliated epithelial cells.

Adolescent↗
PubMed1995

Cervical laminoplasty in patients with ossification of the posterior longitudinal ligaments.

Cervical laminoplasty was the operation used for myeloradiculopathy secondary to ossification of the posterior longitudinal ligaments. Some 57 patients were followed up for 5-13 years (average: 7.8 years). The spinal canal from C3 to C7 was surgically opened en bloc unilaterally with spacer bone grafting to maintain the laminae in a 'kept open' position and thus to implement posterior decompression. No serious major surgery-related complications were observed. Favourable results were obtained in 42 patients (74%), but those with advanced preoperative neurological symptoms did not improve. Patients with spinal canals seriously compromised by anterior ossified lesions recovered poorly. We concluded that laminoplasty is recommended for cervical myeloradiculopathy due to ossified posterior longitudinal ligaments for selected patients, but surgery should be done before the patient has developed serious neurological damage.

Aged↗
PubMed1995

Osteoporotic vertebral collapse with late neurological complications.

This paper describes 27 patients who had a spinal fracture and underwent an anterior or a posterior spinal decompression, with or without spinal instrumentation, for late neurological compromise secondary to post-traumatic vertebral collapse associated with osteoporosis. Five males and 22 females were studied, with an average follow-up of 3.7 years. The patients developed delayed neurological compromise due to osteoporotic vertebral collapse 1 month to 1.5 years following insignificant spinal fractures. Abnormal hypermobility at the collapsed spinal level with gradual retropulsion of fracture fragments into the spinal canal appeared to contribute to late paralysis. This pathology is treated surgically either anteriorly or posteriorly, but we recommend transpedicular posterolateral decompression and stabilization with a screw-rod construct because of technical ease and minimum invasion.

Age Factors↗
PubMed1995

Lumbar spinal stenosis causing intermittent priapism.

The current report concerns the unusual symptom of intermittent priapism, or what may be termed 'involuntary penile erection', associated with proven degenerative lumbar spinal stenosis. Seven patients who were treated for intermittent claudication and spontaneous priapism during walking were studied in terms of clinical presentation, imaging findings, and some electrophysiological testing. Varying degrees of walking and standing tolerance with these unusual symptoms appeared to be correlated with cauda equina constriction as was seen by radiological imaging. Although not statistically valid, external urethral sphincter evoked electromyography suggested the possibility of monitoring the unusual symptom during walking. Surgical spinal decompression is recommended to alleviate this symptom and the claudication.

Aged↗
PubMed1995

Cell proliferation and advancement of hepatocarcinogenesis in the rat are associated with a decrease in connexin 32 expression.

The expression of connexin 32 (Cx32), a major liver gap junction protein, after partial hepatectomy (PH) and during development and progression of hepatocarcinogenesis was studied in the rat. Cx32 was quantitatively analyzed by counting immunohistochemically demonstrated protein spots on the membranes of hepatocytes. Livers were sequentially examined after PH to assess the correlation with cell proliferation. For the analysis of different stages in carcinogenesis, Cx32 was assayed in N-ethyl-N-hydroxyethylnitrosamine-induced enzyme altered foci (EAF), hyperplastic nodules (HN), hepatocellular carcinomas (HCC), pulmonary metastatic HCC and transplanted HCC in relation to their degree of altered enzyme expression. Cx32 showed: (i) a rapid decrease after PH to its lowest levels during and 12 h after the S phase of cell proliferation when 5-bromo-2'-deoxyuridine (BrdU) labeling indices were examined; (ii) a progressive decrease from early preneoplasia EAF to HN and HCC, values for pulmonary metastatic and transplanted HCC being 0; (iii) clearly inverse correlations with increased BrdU index and degree of altered enzyme expression in HN, indicating that these, with the lowest Cx32 count, are closest to HCC. Therefore, the observed decrease appears linked to cell proliferation and progression of hepatocarcinogenesis, providing a reflection of cellular independence and growth advantage.

Animals↗
PubMed1995

Cyclosporin A and FK506 reverse anthracycline resistance by altering the cell cycle.

We investigated the effect of cyclosporin A (CsA) or FK506 on the cytotoxicity of anthracyclines against a human laryngeal cancer cell line, KB cells, and a multi-drug resistance cell line, VJ-300 cells. CsA and FK506 enhanced the cytotoxicity of anthracyclines, especially in the VJ-300 cells. The intracellular concentrations of epirubicin (EPIR), daunomycin (DM), adriamycin (ADM) and THP-adriamycin (THP) were increased by the addition of CsA or FK506 in VJ-300, but not in KB cells. The intracellular accumulation of EPIR was most increased when CsA or FK506 was concomitantly administered with the drug. We also asked whether CsA or FK506 might influence the cycle of KB or VJ-300 cells. The population of cells in each phase of the cell cycle was little changed in both KB and VJ-300 cells when 0.3 microM ADM was administered for 24 h. Both CsA and FK506 significantly increased the ADM-induced accumulation of VJ-300 cells in G2M phase, in comparison with findings with KB cells. Thus, the reversal of MDR by CsA or FK506 is related to increased intracellular concentrations of cytotoxic drugs and, as a result, the increased G2M accumulates in MDR cells. Among of antrhacyclines, EPIR was most effective when concomitantly combined with CsA or FK506 in VJ-300 cells.

Antibiotics, Antineoplastic↗
PubMed1995

Effect of Porphyromonas gingivalis ATCC 33277 vesicle on adherence of Streptococcus mutans OMZ 70 to the experimental pellicle.

The vesicles of Porphyromonas gingivalis ATCC 33277 strongly aggregated Streptococcus cricetus, S. rattus, and S. mutans, but poorly aggregated S. sobrinus. The adherence of S. mutans OMZ 70 to hydroxyapatite (HA) coated with whole saliva was increased in parallel with the quantity of the vesicles. The significant increase of adherence of S. mutans OMZ 70 by the vesicles was also observed on the HA coated with parotid saliva, submandibular saliva, serum, and type I collagen. These findings suggest that the vesicles may act as a bridge between mutans streptococcus and the tooth surface.

Animals↗
PubMed1995

Influence of the muscle tension on the masseteric silent period in children and adults.

Three subject groups who have shown different biting forces were examined in order to investigate whether the physiological phenomenon that the duration of the silent period (SPD) of the masseter muscle would be influenced by background activities of the muscles. They were classified into child (CN, n = 10) and adult groups; the adult group was then further subdivided according to the strength of maximum biting force into a normal group (AN, n = 10) and a low biting force group with some symptoms (AS, n = 5). SPD was observed in the masseter muscles by applying chin tap stimulations during both clenching teeth (10%, 50% and maximum) and biting on a transducer (50 N, 100 N and maximum). With increase of muscle activities, SPD was significantly decreased in the AN and CN groups, whereas no significant changes were found in the AS group. When comparing SPDs among the three groups at the same voluntary effort, the AN group exhibited the shortest SPD followed by the CN and AS groups. The results suggest that SPD was positively influenced by the strength of the background activities of the muscles and that immaturity of the masseters in terms of muscle activity could affect the SPD.

Adult↗
PubMed1995

[Antitumor effect of MMC mixed in Beriplast P].

We attempted to mix an anticancer drug. MMC, with a fibrinogen preparation, Beriplast P (B. P.). First, we examined how MMC was gradually released from its mixture. As the result, its release depended on the MMC concentration in B. P., and the release rate of 1.0 mg MMC from 100 microliters B. P. was 1.6 mg/30 min. Second, we examined the safety of the conjugated drug for normal tissue, because MMC is one of anticancer drugs causing serious damage to normal tissue. When the conjugation of 100 microliters B. P. and below 1.6 mg MMC was coated within one square centimeter, the drug was safe for the endothelium of artery and vein, and the intestinal wall. Third, we attempted an experiment on both the antitumor effect and the role of survival prolongation of the conjugated drug in a mouse carrying a malignant tumor. MMC conjugated with Beriplast P had a highly antitumor effect, which caused necrosis in the cancer cells in unstable conditions. Also, its conjugation drug could inhibit the growth of cancer cells in stable conditions, and prolonged the survival period. From these results, the mixture of MMC and B. P. was found to possess an MMC releasing effect, was safe for normal tissues, and showed high antitumor effect with prolongation of the survival period.

Animals↗
PubMed1995

[Immunopotentiation by OK-432 ointment to apply to the mouse abdominal skin].

The immunopotentiating effect of a streptococcal preparation, OK-432 (Picibanil), mixed with an ointment based Lanolin, was examined. The mixture was applied to mouse abdomen. The effect of OK-432 ointment was compared with those of OK-432 ip and sc. The leucocyte count in the abdominal cavity increased in 3.6 x 10(6) and 12.5 x 10(6) on the 3rd day after ointment application and ip injection of 5 KE OK-432, respectively. The result indicated that OK-432-Lanolin applied to the abdominal skin wall affected the abdominal cavity. IL-6 and IFN-gamma in the abdominal cavity increased in 1.4 ng and 9 ng, respectively, after applying 5 KE OK-432 ointment. From these results the treatment with OK-432 ointment on the abdominal skin exhibited an immunomodulatory effect on the abdominal cavity.

Abdomen↗
PubMed1995

[Chemoradiation therapy with low-dose carboplatin for squamous cell carcinoma of the esophagus].

Twenty-three patients with squamous cell carcinoma of the esophagus were treated with low-dose carboplatin and radiation therapy. Patients received 1.6 Gy-fractions daily; the total dose was 50-70 Gy for 14 unresectable cases, and 30-40 Gy for 8 resectable cases as preoperative irradiation. Carboplatin (30 mg/m2/day) was administered intravenously just before the irradiation; total dose was 1,100-2,000 mg for the unresectable cases, and 750-1,200 mg for the resectable cases. The response rate of the unresectable tumors was 86% (CR 5, PR 7, and NC 2). Three of the five CR patients were alive without recurrence for more than 2 years. The response rate of the resectable tumors was 75%. Although major toxicity was bone marrow suppression, there were no serious complications. These results suggest that this regimen is effective for patients with squamous cell carcinoma of the esophagus.

Aged↗
PubMed1995

Rapidly progressing quadriparesis secondary to cervical pyogenic spondylitis in a patient with Klippel-Feil syndrome.

We report a case in which the patient's quadriparesis progressed rapidly secondary to pyogenic spondylitis with an epidural abscess of the cervical spine. The patient had type II Klippel-Feil congenital fusion at C3-C4 that may have obscured clinical symptoms, resulting in a slight delay in the diagnosis of spondylitis. Magnetic resonance imaging (MRI) facilitated the determination of the precise location of the epidural abscess, and anterior debridement of the involved vertebrae followed by iliac strut bone grafting led successfully to the patient's full neurological recovery. The case presented is instructive in illustrating the importance of an early diagnosis followed by the appropriate treatment.

Abscess↗
PubMed1995

[Prediction of postoperative EEG changes for intractable epilepsy through a multidimensional autoregressive analysis].

Preoperative EEGs were quantitatively analyzed by means of a multidimensional autoregressive model (AR model) in order to predict postoperative EEGs. Recorded preoperative EEGs were digitized at an interval of 10 msec. The AR model fitting was executed on each digitized data. As this model described a multichannel feedback system having a peculiar activity in each site under observation, the interstructural relations could be described distinctly in the direction. Namely, the independent and the projected activities through the feedback circuits could be separately described for each brain site. Therefore, postoperative EEG could be simulated by elimination of the component in the AR model corresponding to each operative region. In this report, we presented three cases and discussed usefulness of this method. Case 1 was a patient with post-traumatic epilepsy, who was treated with focal resection. Preoperative EEGs revealed spike and wave discharges mainly in the right frontal region. Simulated postoperative EEGs based on elimination of component from the right frontal region in the AR model, corresponding to focal resection, revealed disappearance of spike and wave discharges. These findings were quite similar to observed postoperative EEGs. Case 2 was a patient with posttraumatic epilepsy, who was treated with anterior callosotomy. Preoperative EEGs revealed diffuse multifocal slow spike and wave discharges. Simulated postoperative EEGs, based on elimination of interhemispheric feedback pathways in the AR model, corresponding to anterior callosotomy, revealed marked lateralization of diffuse spike and wave discharges to the left hemisphere. These findings were qualitatively similar to observed postoperative EEGs. These results suggested that postoperative EEG changes could be well predicted by multidimensional autoregressive analysis.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1995

[Pharmacological study of 5'-DFUR oral administration and the clinical responses against gastrointestinal carcinoma].

In 4 out of 5 patients given 400 mg orally 5'-DFUR before surgery, intratumor 5-FU concentration showed over 150 ng/g. The concentration of either 5-FU or 5'-DFUR in the portal and peripheral blood of these patients exceeded the limits of assay. 5-FU concentration in peripheral blood was less than 0.05 micrograms/ml. White blood cell and platelet counts in the patients given 1,600 mg/day (no administration for 2 days/week) of 5'-DFUR for one month were essentially the same with those at the time of start of the treatment. Two of three patients showed minor response following the treatment with 5'-DFUR. Thus, administration of 1,600 mg/day of 5'-DFUR may be considered as an effective treatment of fluopyrimidine against advanced cancer. For the prediction of gastrointestinal side effect, assay of the 5-FU concentration in the portal blood seemed to be useful.

Administration, Oral↗
PubMed1995

Central cord syndrome secondary to hyperflexion injury of the cervical spine in a child.

A 10-year-old girl sustained hyperflexion injury to the midcervical spine, i.e., wedge compression fractures of the C3, C4, and C5 vertebral bodies, when hit by an automobile, subsequently manifesting central cord syndrome below the C4 spinal cord level. Serial magnetic resonance imaging helped identify the spinal cord lesion at the corresponding levels. Conservative management combined with corticosteroid administration resulted in nearly full neurologic recovery approximately 3 months after the trauma, although a cystic lesion remained present within the spinal cord 11 months after trauma.

Cervical Vertebrae↗
PubMed1994

Postoperative bone re-growth in lumbar spinal stenosis. A multivariate analysis of 48 patients.

STUDY DESIGN: Forty-eight patients who underwent posterior decompressive surgery for lumbar spinal stenosis were studied. The effect of bone re-growth after posterior decompression in lumbar spinal stenosis on clinical outcome and the factors promoting the bone re-growth were investigated with a multivariate analysis model. METHODS: Bone re-growth at the sites operated upon was evaluated as a percentage of re-growth of the original laminectomy site based upon plain radiographs. The degree of bone re-growth was classified into four groups: 1) no significant re-growth (Group I, bone regrowth rate 10% or less); mild (Group II, 11% to 40%), moderate (Group III, 41% to 70%), and marked (Group IV, 71% to 100%). The average follow-up period was 4.5 years (range, 2 to 7 years). RESULTS: No significant bone re-growth was shown in 6% of the patients. Mild re-growth was shown in 50%, moderate re-growth in 29%, and marked re-growth in 15%. A multivariate analysis indicated that a total block in the preoperative myelogram, a follow-up period of more than 5 years, decompression at more than three spinal levels, and age under 60 years were associated with moderate or marked bone re-growth. Spinal instability accelerated the bone re-growth mainly in the mid and later follow-up intervals. Spinal levels adjacent to a fusion showed more bone re-growth. Patients with moderate and marked bone re-growth had poorer clinical outcomes than those with no significant and mild bone re-growth. CONCLUSION: Bone re-growth in a surgical defect will occur in most patients after posterior decompression. Moderate and marked postoperative bone re-growth are possibly related to recurrence of neurologic symptoms in the middle of and later on in follow-up periods.

Aged↗
PubMed1994

Expression of glutathione S-transferase-pi and sensitivity of human gastric cancer cells to cisplatin.

BACKGROUND: The authors examined the correlation between the expression of glutathione S-transferase-pi (GST pi) and the sensitivity of gastric cancer to anticancer agents. METHODS: In 62 human gastric carcinomas, the expression of GST pi was immunohistochemically evaluated, and sensitivity to the anticancer drugs, cisplatin (CDDP), doxorubicin (DXR) aclacinomycin A (aclarubicin), (ACR), 5-fluorouracil (5-FU), mitomycin C (MMC) and carboquone (carbazilquinon) (CQ) was examined using the in vitro succinate dehydrogenase inhibition test. The authors used the Chinese hamster ovary (CHO) cell line and its variant CDDP-resistant cell line C/CDP-2, and they analyzed the relationship among CDDP-sensitivity, mRNA expression, and immunohistochemical staining. RESULTS: Immunohistochemically detected GST-pi-positive tumors were noted in 35 of 62 excised tumors. There was no significant correlation between GST-pi expression and clinicopathologic features or prognosis. The succinate dehydrogenase activity of each drug for tumors, with regard to negative or positive GST-pi, was 34.9 plus or minus 13.7% and 46.0 plus or minus 22.0% for CDDP, with a significant statistical difference (P < 0.05). However, there was no statistical difference for the other drugs tested. C/CDP-2 cells showed a lower sensitivity to CDDP, a higher expression of mRNA for GST pi and a stronger immunohistochemical staining than CHO cells. CONCLUSIONS: The overexpression of GST-pi is significantly related to the sensitivity of gastric cancer to CDDP.

Aclarubicin↗