Search PubMed⌕ Search

Biomedical subjects

H BROWN

Publications and source records attributed to H BROWN.

At least 19 recordsLinked to original sources

ASCITES.

Explore the source record for details and available documents.

Ascites↗

d-Amphetamine-chlorpromazine antagonism in a food reinforced operant.

Dose effect curves for d-amphetamine and chlorpromazine were obtained with rats on a milk reinforced FR 10 schedule. A dose of d-amphetamine (2.5 mg/kg, i.p.) which completely suppressed all responding for 60 min was administered simultaneously (concomitant with the pretreatment times) with various doses of chlorpromazine. The d-amphetamine-induced cessation of responding was removed by several of the doses of chlorpromazine with maximal antagonism occurring at a dose of 1.5 mg/kg i.p. This dose of chlorpromazine, when administered independently, produced no observable side effects and showed no effect on the FR 10 schedule. One animal appeared to develop tolerance to the repeated dosages of d-amphetamine.

Animals↗