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Biomedical subjects

H B Simon

Publications and source records attributed to H B Simon.

At least 73 records · Page 4Linked to original sources
PubMed1984

The immunology of exercise. A brief review.

Many athletes believe that habitual exercise protects them against infection. This article reviews ten studies of the effects of exercise on various host-defense factors. Exercise produced a transient granulocytosis and lymphocytosis, and in some studies, lymphocyte function was reported to have been enhanced. Serum immunoglobulin and complement levels were not significantly altered in the small number of subjects studied. Two recent studies showed that exercise produced an increase in circulating endogenous pyrogen in man. Since it now appears that endogenous pyrogen is identical to interleukin-1, a product of mononuclear cells that enhances lymphocyte function, it may play a role in host defense. Further studies will be needed before it can be concluded that exercise effects the host response to infection in any clinically meaningful way.

Adult↗
PubMed1984

Creatine kinase levels after jogging in patients with cardiac disease.

Acute muscle injury is a well-documented complication of strenuous exercise, but milder forms of exertion have not been studied in detail. This report describes a patient undergoing cardiac rehabilitation in whom atypical chest pain developed and who was treated for a myocardial infarction only because of an elevated creatine kinase level. Serum creatine kinase levels were determined before and after exercise in 27 patients undergoing cardiac rehabilitation. In 21 patients who jogged less than three miles, creatine kinase levels were not appreciably changed. In six patients who jogged more than three miles, the mean creatine kinase level rose from 41 to 54 mU/ml, an increase of 31 percent. In four of these six patients, creatine kinase levels rose to abnormal levels, but MB creatine kinase levels remained normal, with no clinical evidence of myocardial ischemia. Serum creatine kinase levels should be interpreted with caution in the setting of even modest exercise.

Adult↗
PubMed1984

Indolent meningococcal meningitis: a cautionary tale.

Bacterial meningitis is a medical emergency that is ordinarily rapidly progressive. We present three patients who had meningococcal meningitis with an indolent course. Symptoms were present from two days to four weeks before hospitalization. Cerebrospinal fluid cultures grew Neisseria meningitidis one to eight days before antibiotic therapy, yet all patients remained fully alert and clinically stable during this interval. All recovered after penicillin therapy. In the future earlier diagnosis should be facilitated by an awareness of differing manifestations of meningococcal meningitis, including benign CSF findings, intact sensorium, and an indolent progression. Immunologic studies will be required to clarify the pathogenesis of this syndrome.

Adult↗
PubMed1980

Hemophilus influenzae in hospitalized adults: current perspectives.

In an eight year period 16 cases of serious extrapulmonary Hemophilus influenzae infection in adults were identified, including cases of meningitis, pericarditis, epiglottitis, empyema, cellulitis, osteomyelitis, endometritis, urinary tract infection, orbital cellulitis, primary peritonitis, mesenteric lymphadenitis and aortic graft infection. An 18 month prospective study of H. influenzae infection in hospitalized adults identified 10 cases of bronchitis, 25 of pneumonia and 65 of respiratory tract colonization, but there were no extrapulmonary infections. In 29 percent of the respiratory tract infections, H. influenzae appeared to be a nosocomial pathogen; in 71 percent, the infection was mixed. Finally, 110 clinical isolates of H. influenzae were studied for antimicrobial susceptibility. Eight percent were ampicillin resistant, two strains were resistant to tetracycline and one to chloramphenicol, but all were susceptible to trimethoprim-sulfamethoxazole and cefamandole.

Adolescent↗
PubMed1979

Hormonal hyperthermia: endocrinologic causes of fever.

Although hyperthermia is a component of many endocrine diseases, it is uncommon for fever to be the presenting manifestation of hormonal disorders. During a four year period we encountered six patients, hospitalized principally because of fever, who were found to have endocrine causes for the fever. In all, the admitting diagnosis was infection; three were suspected of having tuberculosis, two of gram-negative bacteremia and one of endocarditis. Except for asymptomatic bacteriuria in one patient (who remained febrile despite appropriate antibiotic therapy) infection was ruled out in all cases, and fever was attributed to "masked" thyrotoxicosis, triiodothyronine (T3) toxicosis, subacute thyroiditis, primary adrenal insufficiency, secondary adrenal insufficiency and pheochromocytoma. In a seventh patient, extreme pyrexia developed in the setting of the thyroid storm. The importance of hormonal mechanisms in thermoregulation is discussed.

Addison Disease↗
PubMed1976

Extreme pyrexia.

Twenty-eight cases of extreme pyrexia seen in a five-year period were analyzed retrospectively. All of the patients had temperatures between 41.1 C (106 F) and 42.2 C (108 F) with a mean maximum temperature of 41.4 C (106.6 F). Infection, thermoregulatory defects, or a combination thereof accounted for fever in these patients. There was little evidence of direct tissue damage caused by fever, and standard therapy with aspirin or acetaminophen, vigorous surface cooling, and volume expansion was generally sucessful. Mortality could be related to the extreme pyrexia in only 7% (2) but an additional 21% (6) of these patients later died from serious underlying diseases.

Adolescent↗
PubMed1976

Chronic lymphadenopathic toxoplasmosis. A case with marked hyperglobulinemia and impaired delayed hypersensitivity responses during active infection.

A patient with lymphadenopathic toxoplasmosis characterized by prolonged symptoms and repeated relapses with isolation of toxoplasma from lymph nodes is described. As the disease persisted and progressed, striking immunologic changes occurred that ultimately resulted in a state of extreme hyperglobulinemia associated with impaired delayed hypersensitivity responses. The case in question illustrates that progressive infection may occur in the face of high antibody levels of all immunoglobulin types whereas the only demonstrable immunologic impairment was of delayed hypersensitivity.

Adolescent↗