Biomedical subjects
Publications and source records attributed to H B Levy.
Chick embryo cells given prior treatment with interferon make new interferon earlier and in larger quantities upon stimulation with Chikungunya virus than cells not so treated. By the criterion of loss of sensitivity to actinomycin, the time needed for formation of messenger RNA for interferon was decreased in the primed cells. Thus interferon affects virus action within 1 hour after infection.
No interferon, or at most a small fraction of that applied, is taken up by cells during the period of induction of antiviral activity. The lack of detectable adsorption was not influenced either by the concentration of interferon or the volume. The results were similar in both chicken and mouse systems.
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