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Biomedical subjects

H B Laursen

Publications and source records attributed to H B Laursen.

16 recordsLinked to original sources
PubMed2000

[Medical continuing education in the county of Vestsjaelland 1995-1997. Young physicians are generally satisfied with their medical training].

During the last few years there has been some criticism concerning the medical training of young doctors. The present study analyses the satisfaction with the medical training (hospitals and general practices) in 401 courses of medical training in the county of West Zealand, Denmark, during the years 1995-1997. The 401 courses resulted in 3136 statements with respect to satisfaction. Only 4.9% of the statements was "discontent", 16.5% "somewhat content", 36.4% "content" and 42.3% "very content". The 4.9% with the statement "discontent" was especially related to the introduction to place of education, focus on medical training and the theoretical lessons. In conclusion the present study revealed general satisfaction in young doctors with the medical training in the county of West Zealand.

Consumer Behavior↗
PubMed1992

Evolutionarily different alphoid repeat DNA on homologous chromosomes in human and chimpanzee.

Centromeric alphoid DNA in primates represents a class of evolving repeat DNA. In humans, chromosomes 13 and 21 share one subfamily of alphoid DNA while chromosomes 14 and 22 share another subfamily. We show that similar pairwise homogenizations occur in the chimpanzee (Pan troglodytes), where chromosomes 14 and 22, homologous to human chromosomes 13 and 21, share one partially homogenized alphoid DNA subfamily and chromosomes 15 and 23, homologous to human chromosomes 14 and 22, share another extensively homogenized subfamily. Such a pattern of homogenization presumably predates speciation 3-10 million years ago. However, the alphoid DNA on these human and chimpanzee chromosomes is not orthologous but originates from two evolutionarily different repeat families. It follows that dramatic sequence evolution has occurred in a concerted fashion among the chromosomes in one or both species during or after separation.

Animals↗
PubMed1992

Higher rate of evolution of X chromosome alpha-repeat DNA in human than in the great apes.

The rate of introduction of neutral mutations is lower in man than in other primates, including the chimpanzee. This species is generally regarded as our closest relative among the great apes. We present here an analysis of sequences of X chromosomal alphoid repetitive DNA from man and the great apes, which supports the closer relationship between man and chimpanzee and indicates a considerably increased rate of recombination in the human repeat DNA. These results indicate that the 'molecular clock' is running more quickly in man.

Animals↗
PubMed1991

[Patient acceptance of NovoLet--an integrated insulin dosage system for repeated use. A multicenter study].

A total of 394 insulin treated diabetic patients from 22 diabetic outpatient clinics all over Denmark were recruited to participate in an open, uncontrolled study of 12 weeks duration. The aim was to test the acceptability of a new pen device, NovoLet, a disposable, multidose pen containing Protaphan 150 International Units. All patients were receiving NPH insulin (Insulatard or Protaphan +/- soluble insulin) prior to inclusion. The insulin regimen otherwise remained unchanged during the study period and 372 patients completed the study. No changes in metabolic control as judged by HbA1c% and frequency of severe hypoglycemic episodes were observed. The total daily insulin dose remained unchanged. Of the 372 patients, 98 were on Insulatard on inclusion in the study. No changes in metabolic control or insulin dose were observed. Patient acceptance of NovoLet was good, 62% would prefer to continue to use it.

Adult↗
PubMed1990

[Screening methods for microalbuminuria in diabetes mellitus].

Persistent microalbuminuria indicates early development of nephropathy, cardiovascular disease and death in patients with diabetes mellitus. In this study morning urines from 189 diabetic patients were investigated with conventional dip sticks, microbumintest and quantitative measurements obtained by immunturbidimetry. Microbumintest has both a higher specificity and sensitivity compared to urinary dip sticks. The immune chemical method is less expensive and alternations in albumin excretion rate can be followed. Quantitative measurement with an immunchemical method is therefore recommended as screening method for microalbuminuria.

Adolescent↗
PubMed1986

[Insulin 100].

Explore the source record for details and available documents.

Humans↗
PubMed1980

Persistent left superior vena cava. Incidence, associated congenital heart defects and frontal plane P-wave axis in a paediatric population with congenital heart disease.

Among 3 671 patients aged 0-15 years with congenital heart disease diagnosed by cardiac catheterization and/or autopsy, 49 or 1.3% had a persistent left superior vena cava (PLSBC). The distribution of PLSVC among patients with various types of congenital heart disease did not suggest any causal relationship except in patients with pulmonary atresia and in patients with anomalous pulmonary venous connection, in whom PLSVC was found more frequently than expected by a mere chance relationship. Abnormal frontal plane P-wave suggesting ectopic pacemaker activity was found in 35% of the patients with PLSVC. The potential importance of PLSVC for the surgical risk during operation for congenital heart disease and for instability of the cardiac rhythm is emphasized.

Adolescent↗
PubMed1980

Some epidemiological aspects of congenital heart disease in Denmark.

Information on 5249 children with congenital heart disease (CHD) in the age group 0-15 years was collected from all paediatric and cardiological departments in Denmark and, furthermore, from death certificates. The mean prevalence for CHD in Denmark was 6.1% during 11 years (1963-73); during the years 1972-73 it was 7.0%. The mean age at detection was 25.86 months; 36% were diagnosed within the first month of life and 63% within the first year. The sex distribution was; 52%, female, 48% male. No seasonal variation was found in the months of birth for individual cardiac anomalies. The largest group of CHD was ventricular septal defect, 24.0%, followed by persistent ductus arteriosus, 12.6%; atrial septal defect, 9.2%; coarctation of the aorta, 7.0%; pulmonary stenosis, 6.0%; and tetralogy of Fallot, 5.8%. The cumulated lethality for all 5249 children ws 25% at 1 month, 42% after 5 years, and 48% at the age of 15 years. CHD was found in 135 cases among 5835 siblings (2.3%).

Adolescent↗
PubMed1979

Congenital heart disease in the first month of life.

During the years 1963--73, 276 children with congenital heart disease were admitted to this hospital during their first month of life. Ventricular septal defect was the most common cardiac anomaly and this lesion, together with transposition of the great arteries, comprised 35% of all cardiovascular malformations. Extracardiac malformations were found in 86 patients. The cumulative survival rate for all patients was 66% in the first month of life and 33% in the first year. Forty-three patients were operated upon, but it is estimated from necropsy reports and available clinical data that another 74 patients, who died without operation, would have been suitable candidates for total corrective surgery.

Abnormalities, Multiple↗
PubMed1976

Congenital heart disease in Down's syndrome.

Eighty cases of Down's syndrome were found among 1504 children with congenital heart disease under the age of 15 years. The most common cardiac anomaly, ventricular septal defect, was found in 49 per cent of the 80 cases studied, while the second most frequently encountered anomaly, common atrioventricular canal, was found in 15%. Haemodynamic investigations of 24 cases of ventricular septal defect showed Eisenmenger's syndrome to be present in 10 cases; this seemed to appear at an earlier age in mongoloid children than in other children with ventricular septal defect. Right-to-left shunt was found in 5 out of 9 cases of common atrioventricular canal. Pulmonary hypertension was found in all of 24 cases of ventricular septal defect and in 7 of 9 cases of common atrioventricular canal. The cumulative survival up to 10 years was 64% for girls and 49% for boys. Death was most commonly the result of pulmonary complications which occurred in 22 out of the 34 patients who died.

Cardiac Catheterization↗
PubMed1975

Familial pulmonary stenosis with underdeveloped or normal right ventricle.

A family with 3 cases of pulmonary stenosis with underdeveloped or normal right ventricle is described. In the family there have also been some spontaneous abortions and many infant deaths, and it seems possible that these were also related to congenital cardiac abnormalities. Recognized syndromes with pulmonary stenosis and reports on familial occurrence of this malformation are reviewed. The cases reported in this paper differ from these previously described syndromes. The possibility of sex-influenced monogenic inheritance is discussed.

Chromosome Aberrations↗
PubMed1975

Thrombocytopenia complicating infectious hepatitis.

A patient of 50 years is admitted to hospital. He is found to be suffering from infectious hepatitis complicated by thrombocytopenia, the initial platelet count being 10 000 per mul soon falling to 2000 per mul. A prompt increase in the number of platelets is seen during treatment with prednisone, but a sudden fall is observed after a gradual reduction of prednisone to zero, the reaction for hepatitis associated antigen at that point still being positive. After a renewed therapy with adrenocortical steroid, the platelet count is within normal limits, and the patient is discharged with a small dose of prednisone. At the time of discharging, the HAA reaction had been negative for 3 weeks. After treatment with a small dose of prednisone for 2 months, the patient was taken into hospital. In the course of one week the dose of prednisone was gradually reduced without any fall in the platelet count. The possibility of lysis of a platelet-virus antigen as an explanation of thrombocytopenia complicating infectious hepatitis is discussed.

Blood Cell Count↗