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Biomedical subjects

H B Fell

Publications and source records attributed to H B Fell.

39 records · Page 3Linked to original sources

The effect of synovial tissue on the breakdown of articular cartilage in organ culture.

UNLABELLED: Living (pig) cartilage in contact with synovium lost both proteoglycan and collagen and sometimes became reduced to a mass of fibroblast-like chondrocytes without matrix; dead cartilage lost proteoglycan but less collagen. Similar changes appeared in living cartilage grown at a distance from the synovium but in the same dish; dead cartilage was unaffected. CONCLUSION: the synovium has a) a direct, presumably enzymatic action on cartilage matrix and b) an indirect effect mediated through the chondrocytes.

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