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H Auchincloss

Publications and source records attributed to H Auchincloss.

96 records · Page 6Linked to original sources
PubMed1982

Anti-idiotypes to monoclonal anti-H-2 antibodies. III. Syngeneic anti-idiotypes on antibodies induced by in vivo administration of xenogeneic anti-idiotypes.

Idiotype-positive molecules induced by xenogeneic anti-idiotypes (anti-Id) to monoclonal anti-H-2 antibodies were studied using syngeneic anti-Id reagents. Syngeneic reagents detected idiotypes on both H-2 antigen-binding and nonbinding Id' induced by xenogeneic anti-Id. In addition, idiotopes were readily detected by alloimmunization after xenogeneic anti-Id reagents interact with some of the same antibodies as syngeneic anti-Id and support the hypothesis that treatment with xenogeneic anti-Id may affect a physiologically important idiotypic network.

Animals↗
PubMed1981

Two distinct murine differentiation antigens determined by genes linked to the Ly-6 locus.

Two separate monoclonal antibodies, 34-11-3S and 34-2-11S, produced by the fusion of C3H anti-BDF1 sensitized spleen cells to the SP2/0 myeloma variant cell line, were found to detect alloantigens on subpopulations of murine lymphocytes. Analysis of the strain specificities of these antibodies showed that both detected antigens determined by genes closely linked to the Ly-6 locus. However, analysis of the tissue distributions of antigen-bearing cells indicated that the 2 antibodies reacted with distinct antigens, only 1 of which was similar in distribution to the classically described Ly-6.2 antigen. Functional studies performed using cells treated with antibody plus C showed that these 2 antibodies defined lymphocyte subpopulations that are different from each other and from those defined by several other reported Ly-6-related antibodies. The data suggest that the Ly-6 locus consists either of multiple tightly linked genes exhibiting marked linkage disequilibrium or of a single gene, the protein product of which is subject to post-translational modifications during cell differentiation leading to the expression of new determinants.

Animals↗