Search PubMed⌕ Search

Biomedical subjects

H Asano

Publications and source records attributed to H Asano.

245 records · Page 14Linked to original sources
PubMedDate not supplied

Growth of Japanese breast-fed and bottle-fed infants from birth to 20 months.

Longitudinal data for weight and length from birth to the 20th month of age obtained from 318 healthy infants were analysed in relation to type of feeding during infancy (breast- or bottle-fed). Differences in the growth patterns of infants according to the type of feeding were confirmed, breast-fed infants tending to be lighter in weight between 6 and 20 months of age than bottle- or mixed-fed infants. However, our analyses of the infants' growth patterns suggest that the differences in mean weight between breast- and bottle-fed infants may be due at least in part to overfeeding of bottle-fed infants. Thus, it is advisable that the standard growth curve for breast-fed infants be based on observations of the growth of a large number of infants who are fed on breast milk only.

Body Height↗
PubMedDate not supplied

Histologic observation of the ductus arteriosus in premature infants with intrauterine growth retardation.

The ductus arteriosus of 19 premature infants with intrauterine growth retardation (IUGR) (study group) was compared histologically with that of 22 infants without IUGR (control group). The two groups exhibited no significant differences in gestational age, age at death, and frequency of disseminated intravascular coagulation. Maternal complications, that is, pregnancy-induced hypertension, cesarean section, and low umbilical artery oxygen tension values, were seen more frequently (p < 0.01) in the study group than in the control group. The histologic changes of ductus arteriosus, such as fragmentation, coagulation necrosis of the intimal elastic lamina, hemorrhage with necrosis, and loosening of elastic fibers and muscles in the tunica media, were seen more frequently in the study group. These findings are suggestive of both the maturation process and the prenatal hypoxic response of premature IUGR fetuses with chronic hypoxia. These changes may have produced subsequent patent ductus arteriosus, which in turn may have induced pulmonary hemorrhage.

Ductus Arteriosus↗
PubMedDate not supplied

Effects of intraaortic balloon pumping on portal venous flow. Assessment with color Doppler echography.

The effects of intraaortic balloon pumping (IABP) on portal venous flow were assessed using color Doppler echography. A total of 23 heart failure patients treated with IABP were assessed. Balloon inflation was timed to occur with every other cardiac contraction. The maximum, minimum, and mean flow velocity (Vmax, Vmin and Vmean, respectively) in the right portal vein were measured with the IABP ON and OFF, and the values compared. The Vmin with IABP ON and OFF was the same (11 +/- 5 cm/sec), whereas the difference between Vmax and Vmean was small for each patient. The velocities measured with IABP ON were larger than or equal to those with IABP OFF in all cases, however, except one. Thus, Vmax (22 +/- 8 cm/sec) and Vmean (17 +/- 6 cm/sec) with IABP ON were significantly larger (p 0.01) than those with IABP OFF (20 +/- 7 cm/sec and 16 +/- 6 cm/sec, respectively). The flow pattern of the portal vein was characteristically pulsatile either with IABP ON or OFF in most cases.

Adult↗
PubMedDate not supplied

Effects of hypoxemia on 11 beta-hydroxysteroid dehydrogenase types 1 and 2 gene expression in preterm fetal sheep.

OBJECTIVE: To examine the effect of sustained hypoxia on the expression of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) type 1 and 2 genes in preterm fetal sheep. METHODS: Fetal liver and kidney as well as placental tissues were collected at days 111-113 of gestation (term = 145 days) after 8 hours of sustained hypoxemia induced by lowering the maternal inspired oxygen (n = 7) or after 8 hours of normoxia to serve as controls (n = 5). Changes in the levels of 11 beta-HSD1 and 11 beta-HSD2 mRNA were determined by Northern blot analysis using ovine 11 beta-HSD types 1 and 2 cDNAs as probes. Levels of 11 beta-HSD2 activity were determined by a standard radiometric conversion assay. RESULTS: In hypoxic fetuses, there was a tendency for a decrease (P = .08) in levels of 11 beta-HSD2 mRNA in the kidney. This decrease was correlated significantly with the degree of associated fetal acidemia (P < .01). However, there were no corresponding changes in the level of renal 11 beta-HSD2 enzyme activity, indicating that changes in 11 beta-HSD2 mRNA were unlikely carried through to 11 beta-HSD2 protein. In contrast levels of 11 beta-HSD1 mRNA in the placenta and fetal liver were unchanged after sustained hypoxia. CONCLUSION: These results demonstrate that fetal hypoxemia-induced acidosis selectively down-regulates 11 beta-HSD2 mRNA expression in the preterm fetal sheep kidney. This may provide a further mechanism whereby fetal acidosis alters developmental processes by regulating the bioavailability of glucocorticoids in specific fetal organs through altered local expression of 11 beta-HSD enzymes.

11-beta-Hydroxysteroid Dehydrogenases↗
PubMedDate not supplied

Tissue DNA synthesis in the preterm ovine fetus following 8 hours of sustained hypoxemia.

OBJECTIVE: Protein synthesis is significantly decreased in the near-term ovine fetus in response to induced hypoxemia of several hours' duration. We therefore sought to determine the extent to which DNA synthesis rates as an index of tissue mitotic activity are also affected by similarly induced compromises in fetal oxygenation. METHODS: Fetal sheep were studied at 0.75 of gestation during a normoxic control period and an 8-hour experimental period of either sustained hypoxemia induced by lowering maternal inspired oxygen concentration of 11-8% (hypoxia group, n = 7) or continued exposure to room air (control group, n = 5). To estimate DNA synthesis rate, [3H]-thymidine (1 mCi/kg) was injected intravenously into each fetus at the beginning of the experimental period. RESULTS: Sustained hypoxemia with a reduction in fetal arterial O2 content from (mean +/- standard error of the mean) 4.3 +/- 0.1 to 1.5 +/- 0.1 mmol/L by the end of study resulted in a variable degree of fetal acidemia, 7.26 +/- 0.03 (range from 7.41 to 7.10), which was entirely metabolic in nature. CONCLUSION: The DNA synthesis rates of most tissues were not significantly changed by the 8 hours of sustained hypoxemia, suggesting that restrictions in protein synthesis in response to fetal hypoxia are initially due to a differential effect on nonmitotic synthetic processes at this stage of development. However, selective decreases in the DNA synthesis rates of the hippocampus (approximately 50%, P < .01), adrenals (approximately 48%, P < .05), and left and right myocardial ventricles (approximately 42% and 27%, respectively, P = .08) were evident which may reflect altered mitotic activity in response to tissue related changes in energy expenditure.

Animals↗