Mice with the Steel mutation were studied to determine whether they showed a morphologic difference in the epithelial-reticular microenvironment of the thymus when compared with their normal and heterozygous littermate controls. Thymuses taken directly from fetal and newborn homozygous SlWehi/SlWehi mice, after culture, and after subcapsular renal grafting were compared by light and electron microscopy with similarly treated thymuses from heterozygous SlWehi/+ and normal homozygous (+/+) littermates. At all developmental stages studied, the homozygous mutants had smaller thymuses with fewer lymphoid cells than their homozygous normal and heterozygous littermates. The homozygous mutants also showed ultrastructural abnormalities in the thymic epithelial cells. After organ culture, homozygous fetal mutant thymuses produced fewer lymphocytes and showed abnormalities of epithelial cell ultrastructure when compared with littermate controls. When mutant and control fetal thymuses were grafted under opposite kidney capsules of normal syngenic recipients, the mutant thymuses developed poorly and showed decreased lymphopoiesis and abnormalities of epithelial cell structure. The data suggest that there is a primary epithelial microenvironmental defect in the thymus of mice with the Steel mutation.

Aging↗

PubMed1979

[Clinical significance of the PHA skin test in patients with lung cancer, pulmonary tuberculosis and leprosy (author's transl)].

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Humans↗

PubMed1978

Radiologic-pathologic correlations of small lung nodules with special reference to peribronchiolar nodules.

A radiologic and pathologic correlation has been made of small lung nodules. At necropsy 100 excised lungs were fixed and slices from them radiographed. The radiographs were used to select individual nodules for histologic study. Nodules in bronchopneumonia, acinonodose tuberculosis, chronic bronchiolitis, and simple pneumoconiosis due to ferric dust were shown to be located around inflamed terminal or respiratory bronchioles. Intraacinar infiltration was usually diffuse, but when nodules were seen, they occurred in peripheral airspaces with no relation to bronchioles. Hematogenous metastases showed distinctly marginated nodules, some truly intraacinar. Although each type of nodule can appear as an "acinar" or "subacinar" image on chest radiographs, this radiologic-pathologic study shows that they differ significantly in their relation to the airway structures.

Adult↗

PubMed1977