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Biomedical subjects

H Appleton

Publications and source records attributed to H Appleton.

25 records · Page 2Linked to original sources
PubMed1977

A possible virus aetiology in outbreaks of food-poisoning from cockles.

In a series of outbreaks of food-poisoning associated with the consumption of cockles, no bacterial pathogens were demonstrable either in faeces of patients or in cockles. However, small round virus-like particles have been detected in a high proportion of the faecal specimens in three of the outbreaks. These particles are similar in size, morphological features and density to particles seen in outbreaks of winter vomiting and non-bacterial gastroenteritis although in preliminary tests they are serologically distinctive.

Cesium↗
PubMed1977

Virus-like particles in winter vomiting disease.

In an outbreak of winter vomiting disease affecting both pupils and staff in a primary school, virus-like particles were found in 7 out of 8 faecal specimens examined by electron microscopy. The particles measured 26 nm in diameter and had a buoyant density of 1-38--1-40 g/cm3 in caesium chloride. They could not be cultured in tissue-culture or organ-culture. In immune electron microscopy tests the particles appeared to differ antigenically from the Norwalk and Hawaii agents. Two out of three patients examined more than one month after their illness were still excreting the particles.

Adult↗
PubMed1975

Hepatitis transmission in marmosets.

The Barker and Berlin strains of hepatitis agent were serially passaged in cotton-topped marmosets, but attempts to isolate a new strain were unsuccessful. Cross-protection tests suggested that the Barker and Berlin agents were serologically related, but normal human immunoglobulin did not protect animals against the Berlin agent. The difficulties encountered in working with captured wild marmosets were considered.

Animals↗
PubMed1975

Hepatitis A in marmosets.

Transmission of hepatitis agents was attempted in marmosets. The Barker hepatitis agent could be serially propagated with difficulty while the Berlin agent consistently induced a striking biochemical and morphological hepatitis in the inoculated animals. Direct inoculation of marmosets with human hepatitis sera produced irregular enzyme changes, but these could not be transmitted in serial passage.

Animals↗