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Biomedical subjects

H Aoyagi

Publications and source records attributed to H Aoyagi.

At least 127 records · Page 7Linked to original sources
PubMed1976

Elevated plasma renin activity in aortitis syndrome.

Plasma renin activity (PRA) was measured in 38 cases of aortitis syndrome. The values of resting peripheral vein blood PRA were 32.2 +/- 4.2 (SE) mmug/ml. These values were 3 times higher than those of normal subjects. Hypertension due to renal arterial stenosis was observed in 18 cases. Their resting PRA values were 41.2 +/- 6.0 mmug/ml, while in the remaining 20 patients without renovascular hypertension those values were 24.2 +/- 5.4 mmug/ml. The patients belonging to aortic arch type or extensive type had 2 times higher PRA values than those of abdominal type. The patients with stenosis or obstruction of common carotid arteries had significantly higher PRA values than the patients without these lesions. Hyperresponse of renin secretion to upright posture was also observed in the same patients with carotid artery stenosis. Abnormal renin release in Takayasu's arteritis disappeared after denervation of the carotid sinus nerve. The present study suggests that the unstable state of carotid sinus reflex is the main cause for the hypersecretion of renin.

Adolescent↗
PubMed1975

Circulating renin in essential hypertension: an evaluation of its significance in the Japanese population.

Plasma renin activity (PRA) was measured in 139 healthy subjects and 200 patients with essential hypertension. There was an obvious relationship between the PRA levels and aging. Elevated PRA values were obtained only in younger subjects under 20 years of age, while the PRA levels were very low only in advanced ages over 60 years. In essential hypertensive subjects, subnormal resting PRA was found in 23.5 per cent, normal PRA in 64.5 per cent, and high PRA in 12 per cent. A marked impairment of renal function and severe retinal changes were observed in the patient with high resting PRA values. On the contrary, hypertensive complications of the kidney and ocular fundi were mild in the patients with low resting PRA values. A reaction of renin secretion was studied in 161 patients with essential hypertension. There were no apparent relationships between the responsiveness of the renin system to intravenous furosemide following upright posture and hypertensive vascular injury.

Adolescent↗
PubMed1975

Plasma renin activity in patients with renovascular hypertension.

Plasma renin activity (PRA) in peripheral and renal vein blood was determined in 25 patients with renovascular hypertension. Significant elevation of resting peripheral vein PRA was observed in only 9 (36%) of them. 11 (61%) out of 18 patients whose conditions were improved by surgery had shown normal levels of resting peripheral vein PRA preoperatively. Provocation test for renin secretion was done in 20 patients. 10 patients showed a hyper-response. 7 out of 15 patients who benefited from surgery had shown no response in PRA on the stimulation. Renal vein PRA was determined in 23 patients. In 16 significantly higher renal vein PRA was found on the affected side. However, measurement of renal vein PRA failed to predict the surgical results in one-third of the patients. Postoperative PRA and blood pressure were followed serially in 10 patients. PRA became normal within 3 days postoperatively in 9 patients. While the normalization of blood pressure following operation was more rapid in 3 revascularized patients than in 7 nephrectomized, the normalization of PRA was quicker in the latter patients than in the former. These data indicate that measurement of PRA in peripheral and renal vein is not an infallible mean to determine the functional significance of renal arterial lesions.

Adolescent↗
PubMed1975

Effects of 1-sarcosine-8-isoleucine-angiotensin II on blood pressure and plasma renin activity in various types of hypertension.

The pharmacological effects of 1-Sar-8-Ile-angiotensin II on blood pressure and plasma renin activity (PRA) were studied in 5 normal subjects and in 19 patients with hypertension of various etiologics including malignant hypertension, renovascular hypertension, essential hypertension, and primary aldosteronism. Intravenous administration of this peptide induced a significant pressor response in normal or low PRA subjects at infusion rates of 100-600 ng/kg/min. Similar pressor response was also observed in renovascular hypertensives with normal PRA who were cured later by surgical treatment. The blood pressure in high PRA group was lowered remarkably by infusion of this angiotensin II inhibitor. A significant increase in PRA was obtained in subjects with malignant hypertension following the infusion of this peptide. However, there was no detectable rise in PRA in other subjects with normal or high PRA. The present data show that circulating angiotensin II plays an important role in maintaining high blood pressure in high PRA patients, especially in malignant hypertension, while it is not directly involved in the maintenance of high blood pressure in human chronic renovascular hypertension.

Adolescent↗