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H Ando

Publications and source records attributed to H Ando.

460 records · Page 26Linked to original sources
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Atypical primary sclerosing cholangitis cases associated with unusual pancreatitis.

BACKGROUND/AIMS: We encountered one group of primary sclerosing cholangitis cases which met classic criteria, but demonstrated better clinical courses. METHODOLOGY: We evaluated the clinical characteristics of several cases of primary sclerosing cholangitis, especially those associated with chronic pancreatitis. RESULTS: Of a total of 25 cases, eight had a background of pancreatitis with unusual irregularly segmental or diffuse narrowing features on pancreatography. Abdominal ultrasonography and computed tomography also revealed segmental or diffuse enlargement of the pancreas. Pathological findings of surgical specimens in two cases pointed to lymphoplasmacytic sclerosing pancreatitis. The walls of the lower biliary ducts were also thickened with a similar appearance to the pancreatic ducts. In seven cases, cholangiography displayed stenosis of the lower part of the common bile duct and in one case, only the hepatic hilar region was affected. In this case both biliary and pancreatic lesions responded to steroid therapy simultaneously. One case developed hepatic hilar stenosis four months after a lesion in the lower part of the common bile duct had disappeared. The cases of primary sclerosing cholangitis with pancreatitis demonstrated better clinical courses than did typical cases of primary sclerosing cholangitis. Six cases were characterized by autoimmunological abnormalities. CONCLUSIONS: We concluded that similar etiological agents might impact on both the pancreas and biliary tract, either simultaneously or in sequence. We propose new criteria for these atypical primary sclerosing cholangitis cases.

Aged↗
PubMedDate not supplied

Open-heart surgery in infants using pulsatile high-flow cardiopulmonary bypass.

Pulsatile high-flow cardiopulmonary bypass (2.5 l/m2/min with a rectal temperature of 28 degrees C) combined with the Pulsatile Bypass Pump (Kontron Instrument) has been used at Fukuoka Children's Hospital in 259 cases of open-heart surgery in patients less than 1 year of age for a period of 5 years beginning July 1982. The overall results were satisfactory with a surgical mortality of 6.2% (VSD: 96 cases/2 deaths, TGA: 48/1, TAPVD: 34/3, Complete ECD: 15/1, IAA: 10/1, DORV: 10/1, HLHS: 7/4, TOF: 6/0, Truncus Art: 5/0, Others 28/3). The mean duration of cardiopulmonary bypass was 123 +/- 50 minutes during which time the patients had a positive water balance of only 28 +/- 38 ml per kg of body weight. The lowest positive water balance was noted in the patient group with 60-75 mmHg in peak systolic pressure and 30-45 mmHg pulse pressure divided by the pulsatile wave form. This value was significantly lower than other groups of patients with lower or higher peak systolic and pulse pressures. Urinary output during the first 24 hours after operation was 4.1 +/- 1.3 ml/kg/hour. Weight gain on the first postoperative day was 10 +/- 43 g per kg of body weight, and the duration of postoperative respiratory support was 4 +/- 5 days. In conclusion, pulsatile high-flow cardiopulmonary bypass is useful in infant open-heart surgery in light of operative techniques, water balance and postoperative recovery.

Cardiopulmonary Bypass↗
PubMedDate not supplied

Hopantenic acid beta-glucoside as a new urinary metabolite of calcium hopantenate in dogs.

The metabolism of calcium hopantenate (HOPA) was studied in beagle dogs. After oral administration of 14C-labeled HOPA, 25.5% of the administered radioactivity was excreted in the urine within 24 hr, mostly in the form of unchanged drug. The only metabolite, accounting for 4.2% of the radioactivity in the urine, was isolated by HPLC. The metabolite was hydrolyzed by the treatment of beta-glucuronidase (Helix pomatia), acid phosphatase, or beta-glucosidase. These enzyme activities were not inhibited by treatment with D-glucaric acid 1,4-lactone or PO4(3-), but with D-gluconic acid 1,5-lactone, demonstrating that the metabolite is a glucose conjugate. The compound was identified as HOPA-glucoside, 4'-O-(beta-D-glucopyranosyl)-D-hopantenic acid, by GC/MS analyses after derivatization of the metabolite and the synthetic compound. This is the first reported instance of glucose conjugation to a non-acidic hydroxyl group in the metabolism of xenobiotics in mammals.

Animals↗
PubMedDate not supplied

Metabolism of ethyl 2-(4-chlorophenyl)-5-(2-furyl)-oxazole-4-acetate, a new hypolipidemic agent, in the rat, rabbit, and dog. Glucuronidation of carboxyl group and cleavage of furan ring.

Metabolism of ethyl 2-(4-chlorophenyl)-5-(2-furyl)-oxazole-4-acetate (TA-1801), a new hypolipidemic agent, was studied in the rat, rabbit, and dog. Animals were given a single oral dose of 50 mg/kg TA-1801 labeled with 14C. The first metabolic reaction for TA-1801 was hydrolysis of the ester linkage. The resulting metabolite M1 was found to undergo further biotransformations, i.e. glucuronidation at the carboxyl group and ring cleavage of the furan group. These metabolic pathways were observed in all the species examined, although species differences were seen in the amount of metabolites.

Animals↗
PubMedDate not supplied

Identification of germ line mutation of APC gene in possible carriers of familial adenomatous polyposis (FAP).

In Japan 1052 FAP patients in 688 family trees have been registered at the National Polyposis Center. In Hamamatsu University School of Medicine, we have been treating 50 patients in 28 family trees. Among these families, we analysed the site of mutations of the APC gene, which so far has been clarified in 21 family trees. Presymptomatic diagnosis was possible in 12 individuals among the carriers in 6 FAP families. Most of the mutations were clustered within the 5'half of exon 15. There was no correlation between extra colonic phenotypic expression and site of mutation, however, the desmoid should be studied further, as the number of cases was limited.

Adenomatous Polyposis Coli↗
PubMedDate not supplied

Influence of endotoxemia on hepatic energy metabolism in rats with obstructive jaundice.

BACKGROUND/AIMS: A secondary insult in patients with obstructive jaundice can lead to multiple system organ failure. We evaluated the influence of endotoxin on hepatic energy metabolism and hepatic tissue blood flow in obstructive jaundiced rats. MATERIAL AND METHODS: Male Sprague-Dawley rats were divided into a control group, an endotoxin administration group, an obstructive jaundice group, and an obstructive jaundice with endotoxin administration group. To evaluate hepatic energy metabolism, we have measured arterial blood ketone body ratio, and arterial blood total ketone body concentration. Hepatic tissue blood flow was determined by laser Doppler velocimetry. RESULTS: In the endotoxin administration group, no change was observed in hepatic energy metabolism. However, the obstructive jaundice group was associated with decreased hepatic tissue blood flow shortly after the outset of jaundice, while no change was observed in hepatic energy metabolism until 3 weeks later. In the obstructive jaundice with endotoxin administration, a significant decrease in hepatic tissue blood flow and an increase in hepatic energy metabolism were measured. CONCLUSION: Endotoxin administration alone had no influence on hepatic energy metabolism, while endotoxin administration in the presence of obstructive jaundice results in a rapid decrease in hepatic energy metabolism. This occurred as a result of the secondary insult of endotoxin in the setting of decreased hepatic tissue blood flow caused by obstructive jaundice.

Animals↗
PubMedDate not supplied

Results of a pylorus-preserving pancreatoduodenectomy for pancreatic cancer: a comparison with results of the Whipple procedure.

BACKGROUND/AIMS: A pylorous-preserving pancreatoduodenectomy (PPPD) was performed in patients with an invasive ductal adenocarcinoma of the pancreatic head, but with no direct invasion to the duodenal bulb or pyloric ring and no perigastric lymph node metastasis. This study compares the results achieved by the Whipple procedure in patients with invasive ductal adenocarcinoma of the pancreatic head. METHODOLOGY: Over the past 14 years, we have treated 109 patients with an invasive ductal adenocarcinoma of the head of the pancreas, this number excluding low-grade malignancies such as intraductal papillary mucinous carcinoma or cystadenocarcinoma. The postoperative survival rate, level of postoperative social activity and changes in body weight were studied in 48 resected patients and compared with the results of those who underwent the Whipple procedure. RESULTS: In the resected patients, the 3-year survival rate was 20.8%, and the 5-year survival rate was 16.7%. All patients who underwent the bypass operation, however, had a survival rate of less than 2 years, hence the prognosis for resected patients was better (p < 0.01). Among the resected patients, the postoperative survival rate was better in those who underwent a curative resection than in those who underwent a non-curative resection (p < 0.01). No difference was observed in the postoperative survival rate of PPPD vs Whipple procedure patients. The level of postoperative resumption of social activity and changes in body weight were significantly better after the PPPD than after the Whipple operation. CONCLUSIONS: For patients with cancer of the pancreatic head, but with no direct invasion of the duodenal bulb or pyloric ring and no perigastric lymph node metastasis, a PPPD proved more effective than the Whipple operation. Further, as the prognosis was also better after curative resection, an extended lymphadenectomy in conjunction with the PPPD was also considered necessary to ensure a cancer-free state following resection.

Adenocarcinoma↗