[Prospective study of the timing of recanalization with a conventional guide wire/catheter system in arterial occlusions].
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Adult↗
Biomedical subjects
H Alfke
Publications and source records attributed to H Alfke.
A case of an anomalous pulmonary vein of the right middle lobe.
A case is reported in which the abnormal course of a pulmonary vein was suggested by computed tomography and confirmed by digital subtraction angiography. The vein drained blood from the right middle lobe into the apical pulmonary vein. This abnormality was probably due to abnormal segmentation of the right lung. Comparable cases have been reported in the literature. It is important to distinguish these benign lesions from more complex malformations because of the therapeutic and prognostic implications. The radiologic findings of this case and a systematic overview of pulmonary vein abnormalities is provided.
Aged↗
Local intravascular drug delivery: in vitro comparison of three catheter systems.
PURPOSE: The aim of this in vitro study was to compare different catheter systems for local drug delivery with respect to the penetration depth of a biotin marker solution delivered into the vessel wall. METHODS: Post-mortem carotid arteries from pigs were locally infused with a biotin solution using three different catheter systems. With all catheters (microporous balloon catheter, hydrogel-coated balloon catheter, and spiral balloon catheter) we used the same pressure of 405 kPa (4 atm) and infusion times of 60, 90, and 300 sec. After infusion the arteries were histologically prepared and stained using a biotin-specific method. With a light microscope an observer, blinded to the catheter type, scored the amount of biotin within the vessel wall, measured as staining intensity, and the penetration depth of the biotin. RESULTS: Delivery with the hydrogel-coated balloon catheter was limited to the intima and the innermost parts of the media. The spiral balloon and microporous balloon catheter showed both a deeper penetration and a larger amount of delivered biotin compared with the hydrogel catheter, with a slightly deeper penetration using the microporous catheter. The penetration depth showed a correlation with infusion time for the spiral balloon and microporous catheters, but not for the hydrogel-coated catheter. CONCLUSION: Different catheter designs lead to different patterns of local drug delivery. The differences in penetration depth and amount of the substance delivered to the vessel wall should be known and might be useful for targeting specific areas within the vessel wall.
Analysis of Variance↗