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Biomedical subjects

H Akiba

Publications and source records attributed to H Akiba.

At least 91 records · Page 5Linked to original sources
PubMed1975

Defective DNA repair replication in xeroderma pigmentosum fibroblasts and DNA repair of somatic cell hybrids after UV irradiation.

Primary fibroblast cultures were obtained from 9 patients with xeroderma pigmentosum of various clinical types. Repair replication of the UV-damaged DNA in fibroblasts was studied by means of 3H-thymidine labeling and radioautography. A DNA repair replication was found to be decreased in all xeroderma pigmentosum fibroblasts as compared with the control cells obtained from normal donors. The repair activities in cells from patients ranged from nearly 0% in two infant cases and one case of De Sanctis-Cacchione syndrome to approximately 100% in adult moderate case. There was, however, no correlation between the level of repair replication and the severity of clinical symptoms. Since two cases which showed a lack of repair DNA replication were infant, it is assumed that these cases may develop De Sanctis-Cacchione syndrome in future. On xeroderma pigmentosum cells, a genetic analysis was performed with cell fusion methods using irradiated HVJ virus in order to determine the type of the complementation group. XP-1, XP-4 and XP-9 may be classified into the group D; XP-2, XP-7 and XP-8 into the group A; and XP-5 into the group E.

Adolescent↗
PubMedDate not supplied

Spontaneously reduced midgut malrotation: CT diagnosis.

Midgut malrotation is a relatively rare congenital malformation that arises from an error of rotation and fixation of the midgut. We report a case of spontaneously reduced duodenal malrotation diagnosed by computed tomography and roentgenography after the ingestion of barium.

Adult↗
PubMedDate not supplied

Pseudoaneurysm of the superficial femoral artery in Behçet's disease with spontaneous thrombosis followed by CT angiography.

A 25-year-old man developed sudden pain and a pulsating mass in the left thigh. A diagnosis of Behçet's disease was made because of four major symptoms. Laboratory data indicated active inflammation. Emergency spiral computed tomographic angiography (CTA) showed an aneurysm of the left superficial femoral artery (SFA). Under steroid therapy, follow-up spiral CTA showed spontaneous occlusion of the aneurysm. In the active phase of arteritis, spiral CTA is useful for the diagnosis of arterial lesions to avoid the arterial puncture of conventional arteriography.

Adult↗
PubMedDate not supplied

Pulmonary alveolar microlithiasis: high-resolution CT and MR findings.

We report the high-resolution CT (HRCT) and MR findings in a case of pulmonary alveolar microlithiasis. HRCT revealed that the black pleural line on a chest radiograph was caused not by subpleural cysts but by a fat-dense layer between ribs and the calcified parenchyma. MRI showed both lower zones with diffusely increased signal intensity on T1-weighted images. We speculated it was caused by the accumulation of small-sized calcific particles.

Biopsy↗
PubMedDate not supplied

Anomalous vessels in the middle ear associated with congenital anomalies of the internal carotid artery.

A case with unilateral hypoplasia of the internal carotid artery was reported. The rerouting of anomalous vessels in the middle ear, visualized by otoscopy, was demonstrated with CT and MRI. Associations with internal carotid hypoplasia, the intercarotid collaterals, both anomalous middle ear arteries and the enlarged internal maxillary artery were confirmed with MRI. MR images were helpful to diagnose not only the anomalous vessels but also the multiple anastomoses.

Carotid Artery, Internal↗