Bactericidal and opsonizing effects of human serum on Escherichia coli O7 K1.
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Antibodies, Bacterial↗
Biomedical subjects
H A Rowland
Publications and source records attributed to H A Rowland.
The serum bactericidal and opsonizing defect in sickle cell anaemia: restoration of activity by control serum.
Thirty-eight homozygous sickler sera were compared with a large pool of serum from healthy African non-sicklers with regard to bactericidal and phagocytic indices. One third of the sera showed reduced bactericidal activity against Salmonella enteritidis which was restored by the addition of 4% control serum; control serum provided both heat-labile (HL) and absorbable (ABS) serum factors. 76% of test sera showed greatly defective opsonization as indicated by ingestion by normal human neutrophils. Activity was not readily restored by the addition of control serum which provided only HL factors. Intracellular survival was increased when bacteria were ingested from sickler serum; activity was readily restored by control serum which provided both HL and ABS factors. In the presence of both serum and neutrophils 84% of test sera permitted increased bacterial survival; the defect was not readily reversed by the addition of control serum which provided both HL and ABS factors.
Anemia, Sickle Cell↗
Immune T-cells and their lymphokines enhance phagocytosis of merozoites by macrophages.
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Animals↗
Toxocariasis in the British Isles 1982-3.
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Adolescent↗
The bactericidal and opsonic effects of serum from patients with sickle cell anaemia.
The bactericidal and opsonic activity of serum from 12 homozygous sicklers was compared with that of a single control pool of healthy nonsickler African serum. Factorially designed experiments were used to calculate 4 indices which were expressed as the ratio of test to control. Using S. enteritidis and normal human neutrophils viability indices (VI) were calculated for serum, for ingested organisms and for cells + serum, together with a phagocytic index (PI) for cells. Only 1 of the 12 sickler sera gave values equal to that for the control, the remainder showing marked deviation. The survival of organisms in sickler serum was 3 times that in control serum. Phagocytosis by neutrophils in the presence of test sera was only 10% of that in control sera and survival of ingested bacteria was 6 times greater. In the presence of neutrophils overall bacterial survival was 22 times greater for sickler than for control serum.
Anemia, Sickle Cell↗
The pathogenesis of diarrhoea.
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Anti-Bacterial Agents↗
Imported diseases.
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Emigration and Immigration↗
Mathematical methods in research in tropical medicine.
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Age Factors↗
Here from the tropics: management of recently arrived patients.
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Emigration and Immigration↗
Management of patients recently arrived from the tropics.
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Amebiasis↗
Stibokinetics. II. Studies on mice with 124Sb-labelled potassium antimony tartrate: blood concentrations.
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Animals↗
Stibokinetics. 3. Studies on mice with 124Sb-labelled potassium antimony tartrate tissue concentrations: excretion.
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Animals↗
Stibokinetics I: studies on mice with 124Sb-labelled sodium antimony dimercaptosuccinate (astriban).
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Animals↗