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Biomedical subjects

H A Oberman

Publications and source records attributed to H A Oberman.

At least 55 records · Page 3Linked to original sources
PubMed1988

Cytophotometric measurements of metaplastic carcinoma of the breast: correlation with pathologic features and clinical behavior.

The DNA content of the various neoplastic elements of 12 Feulgen-stained metaplastic breast carcinomas was measured by image analysis. Spindle cell, osseous, chondroid, rhabdomyoid, or squamous cell metaplastic elements comprised at least half of each neoplasm in which an invasive ductal carcinoma component also was identified. The epithelial elements in all of the neoplasms were aneuploid, as was the metaplastic component in 11 of the cases. Multiple stem cell lines were detected in the ductal carcinoma component in 4 cases and in the metaplastic components in 5 cases. Our findings lend support to the view that metaplastic elements are derived from malignant epithelial cells, rather than from benign stromal cells. Neither aneuploidy nor the presence of multiple stem cell lines was a useful predictor of the biologic behavior of these 12 neoplasms.

Adult↗
PubMed1987

Invasive carcinoma of the breast with granulomatous response.

Three patients are described who had invasive ductal carcinoma associated with noncaseating epithelioid granulomas. Multinucleated giant cells, predominantly of Langhans' type, were present in the granulomas. The granulomas were restricted to the carcinoma, and no granulomatous response was evident in regional lymph nodes. None of the patients had clinical evidence of systemic granulomatous disease, although one patient subsequently was found to have hepatic portal granulomas. This uncommon tissue response to neoplasm is distinct from carcinomas with osteoclast-like multinucleated giant cells. Similarly, the process differs from the granulomas presenting in axillary lymph nodes that drain a carcinoma.

Aged↗
PubMed1987

Metaplastic carcinoma of the breast. A clinicopathologic study of 29 patients.

The clinical and pathologic findings in 29 patients whose primary breast neoplasm manifested the microscopic pattern of spindle cell carcinoma or extensive squamous or pseudosarcomatous metaplasia were studied. In several of the tumors, the diagnosis of primary sarcoma or squamous cell carcinoma was excluded only after a prolonged search for evidence of invasive ductal carcinoma. The paucity of axillary lymph node metastases and the circumscription of these neoplasms belied their aggressive clinical behavior. The size of the neoplasm at the time of initial treatment best correlated with prognosis, since the majority of patients whose carcinoma was less than 4 cm in diameter pursued a favorable course. The lack of correlation of the microscopic pattern of these neoplasms with prognosis, as well as the presence of apparent overlapping microscopic findings, supports the concept that they are variants of a single entity.

Adult↗
PubMed1985

Juvenile (cellular) adenofibromas. A clinicopathologic study.

"Juvenile" adenofibromas that presented in 25 patients were reviewed. All of the patients were in the second decade of life. The tumors were solitary in 19 patients and multiple and bilateral in six patients. All were distinguished microscopically by prominent cellularity of both epithelium and stroma. Patients who presented with solitary tumors, regardless of size, microscopic pattern, or manner of excision, had no recurrence. In contrast, all patients who presented with multiple tumors developed additional benign masses, often requiring re-excision. We believe that solitary "juvenile adenofibromas," regardless of size, should be excised so as to preserve as much breast tissue as possible. Those patients with multiple, bilateral tumors may anticipate recurrences, but malignant change is not seen. Tumors with this microscopic pattern also may occur, albeit uncommonly, in adults.

Adenofibroma↗
PubMed1984

Infarction and squamous metaplasia of intraductal papilloma: a benign breast lesion that may simulate carcinoma.

Infarction of intraductal papillomas is uncommon. Six lesions of this type was referred to the authors as diagnostic problems, and two additional cases were found in a review of in-patient material. The patients' median age was 62 years (range, 30 to 81 years), and in each case the mass had been asymptomatic. Although the architectural pattern of the papillomas remained intact, ischemic necrosis rendered histologic evaluation difficult. Squamous metaplastic epithelium was present in three cases. Distortion of residual viable ductal epithelium by fibrosis at the periphery of the papillomas closely simulated invasive carcinoma. The appearance of the lesion on low-power magnification, the absence of malignancy elsewhere in the sample, and the absence of cytologic features of malignancy are useful criteria for distinguishing this lesion from carcinoma. None of these lesions recurred in the six patients for whom follow-up information was available (follow-up period, one to 20 years).

Adult↗
PubMed1983

Cellular adenomyoepithelioma of the breast.

This report is the second documented case of an adenomyoepithelioma arising in the breast. The neoplasm was well circumscribed and possessed cytologic features suggestive of a low-grade cancer; however, its biologic behavior remains undefined. The epithelial and myoepithelial elements are characterized ultrastructurally, and both are active participants in the neoplastic process. There are some histologic similarities of this lesion to the salivary gland epithelial-myoepithelial carcinoma; however, the growth pattern of cellular interductal proliferation of myoepithelium is unique.

Breast Neoplasms↗
PubMed1980

Secretory carcinoma of the breast in adults.

Six examples of a breast neoplasm distinguished by gross and microscopic circumscription and prominent intracellular and intraacinar mucin are presented. These neoplasms are analogous to similar tumors which, although rare, more characteristically occur in the breasts of children. They apparently are slow-growing lesions and none manifested either local recurrence or metastases.

Adult↗
PubMed1980

Radiology of olfactory neuroblastoma.

Olfactory neuroblastoma is often misdiagnosed pathologically. The authors reviewed eight such cases in which the pathological findings met strict criteria. These neoplasms are locally invasive in the nose and paranasal sinuses, with frequent intraorbital and intracranial extension as well as distant metastases. A rare primary presentation in the sphenoid sinus-clivus region is described. Computed tomography is the procedure of choice in defining intraorbital extension and is complementary to precision laminagraphy for defining intracranial extension. Angiography frequently shows hypervascularity and may be of further help in assessing intracranial extension.

Angiography↗
PubMed1979

Tubular carcinoma of the breast.

Twenty-five patients with tubular carcinoma of the breast were reviewed. All of the lesions were small, averaging 0.9 cm in diameter, and none exceeded 2.0 cm in diameter. Regardless of treatment, the prognosis proved favorable. Only three of the patients manifested axillary lymph nodal metastases, and none died of recurrent or metastatic neoplasm. These neoplasms frequently were associated with intraductal carcinoma and, to a lesser extent, with lobular carcinoma in situ. It is concluded that tubular carcinoma represents a slow-growing expression of invasive mammary carcinoma; nevertheless, it is likely that, if inadequately treated, these lesions will evolve into more common patterns of invasive carcinoma.

Adult↗
PubMed1978

Heterotopic submucosal gastric cysts: Report of two cases, one in association with carcinoma.

Two cases of heterotopic submucosal gastric cysts, one with a coexisting superficial spreading carcinoma, are described. This is an uncommon entity with which radiologists should be familiar. An association between such cysts and carcinoma has been predicated previously. The induction of submucosal gastric cysts in monkeys fed polychlorinated biphenyls is cited, and the potential significance of this observation with regard to such lesions in humans is discussed.

Adenocarcinoma↗