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Biomedical subjects

H A Ellis

Publications and source records attributed to H A Ellis.

68 records · Page 4Linked to original sources
PubMed1972

Quantitative observations on mineralized and non-mineralized bone in the iliac crest.

The amounts of mineralized bone and osteoid in thin undecalcified sections of iliac crest have been measured in 68 control subjects at necropsy using a point-counting method. The effect of varying the site selected for quantitative study on the value obtained for total bone mass has been investigated in decalcified sections of iliac crest. The total bone mass shows individual variation within a fairly constant range with a mean of 22.7 +/- 0.5% up to the age of 50 years and then progressively falls to a mean of 15.5 +/- 1.1% for individuals aged > 50 years. Some of the lowest values in the range 5.5 to 16.4 (mean 8.9 +/- 1.9%) were observed in elderly women in the seventh to ninth decades. It is concluded that so-called senile osteoporosis is usually a manifestation of a normal aging process. In controls osteoid accounts for only about 0.1% of the area measured and for a maximum of 1.8% of bone with a mean mineralization of 99.5%. Osteoid is patchily distributed and the maximum number of birefringent lamellae in any seam is four. The results of quantitative histology carried out in different parts of the iliac crest indicate that there are variations with the distance of the site from the anterior superior spine and its depth below the crest surface. The importance of this in relation to the site and size of iliac crest biopsies used for quantitative histology is discussed. There is a significant correlation between the values for total bone mass when estimated by the point-counting technique in undecalcified sections and by a volumetric method using blocks of bone.

Adolescent↗
PubMed1971

Recurrent hyperparathyroidism due to parathyroid carcinoma.

The case is described of a woman who died with a functioning parathyroid carcinoma 19 years after removal of two parathyroid tumours, considered at the time to be benign. Following operation hyperparathyroidism subsided, with a short period of hypocalcaemia, and severe osteitis fibrosa cystica healed. Five years before death progressive renal failure developed with normal and later raised serum calcium levels. At necropsy a parathyroid carcinoma infiltrated the thyroid at the site of the previous operation and there was a solitary hepatic metastasis. A remaining parathyroid gland was nodularly hyperplastic and the bones showed evidence of active osteitis fibrosa. The relationship between parathyroid hyperplasia and neoplasia is discussed. Acceptable cases of parathyroid carcinoma are rare, but carcinoma is an important cause of recurrent hyperparathyroidism even months or years after removal of an ;adenoma'.

Adenoma↗
PubMedDate not supplied

Pseudarthrosis of the radius associated with neurofibromatosis. A case report.

A seven-year-old-boy with neurofibromatosis developed pseudarthrosis of the radius. After treatment by external electrical stimulation of the forearm failed, the pseudarthrosis was excised and the proximal and distal ends of the radius were osteotomized. The bone segments were reversed to correct the deformity and to place bone adjacent to the pseudarthrosis in contact with normal bone. This operation has not been described previously for this condition and, as in all previous reports, failed to produce union. Surprisingly, the excised pseudarthrosis showed no histologic evidence of neurofibroma or impaired osteoblastic function. The surrounding soft tissues may play an important role in the establishment and maintenance of the condition.

Child↗