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Biomedical subjects

H A Briele

Publications and source records attributed to H A Briele.

23 records · Page 2Linked to original sources
PubMed1982

Steroid receptors in human lung cancer cytosols.

Receptors for all classes of steroid hormones were identified in cytosols of adenocarcinoma of the lung. In contrast, the incidence of receptor in squamous cell carcinoma was limited and small cell carcinomas appeared devoid of receptor. Receptor binding was of high affinity, saturable and localized to the 8, 6-7 and 4s regions of sucrose density gradients. Demonstration of high affinity cytosol receptors for steroids in adenocarcinoma and squamous cell carcinoma of the lung provides suggestive initial evidence that steroids may influence the natural history of a subset of human lung carcinomas.

Adenocarcinoma↗
PubMedDate not supplied

Incidence of estrogen receptor in benign nevi and human malignant melanoma.

This study was performed as an initial step to evaluate the possible effects of steroid hormones on benign nevi. Cytoplasmic receptors for estrogen were found in nine (41%) of 21 benign nevi from melanoma patients. Ten (37%) of 27 melanoma tumor tissues also had receptor for estrogen. Benign nevi from 17 normal persons had no estrogen receptor activity. The similar incidence of estrogen receptor in benign nevi from melanoma patients and in melanoma tissue itself, compared with the absence of receptor in benign nevi from a normal population, suggest that steroid hormones such as estrogen may represent a molecular alteration associated with a potential pathophysiologic transformation of a benign nevus to its malignant counterpart.

Cytoplasm↗