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Biomedical subjects

Gunnar Lose

Publications and source records attributed to Gunnar Lose.

24 records · Page 2Linked to original sources
PubMed2003

A comparison of three methods to evaluate maximum bladder capacity: cystometry, uroflowmetry and a 24-h voiding diary in women with urinary incontinence.

BACKGROUND: Maximum bladder capacity (MBC) is an important parameter in the evaluation of lower urinary tract function. Yet, there is no consensus on how to measure MBC. The aim of this study was to compare estimates of the maximum bladder capacity (MBC) using cystometry, uroflowmetry, and a 24-h voiding diary in women with urinary incontinence. METHODS: From 1 January 1998 to 31 December 1998 a retrospective review comprising 60 incontinent women in whom cystometry, uroflowmetry, and a 24-h voiding diary were performed were evaluated. RESULTS: Median age was 55 years (range: 34-90 years). In women with detrusor instability (DI), MBC was significantly higher when measured using a voiding diary (median: 400 ml) as compared with cystometry (median: 215 ml) (p = 0.017). A 'Bland-Altman plot' demonstrated poor agreement between MBC in women with DI measured using a voiding diary and cystometry, respectively. The cystometric MBC was significantly higher in women with a stable detrusor (373 ml) as compared with women with DI (215 ml) (p = 0.0027). However, in women with or without DI there were no differences between MBC measured either using a voiding diary (400 vs. 360 mL) or by uroflowmetry (260 vs. 254 ml), respectively. CONCLUSIONS: A low cystometric MBC in women with DI may be an 'artefact' caused by the cystometric procedure (catheterization and filling). The question is which measure of MBC is the best for clinical and scientific purposes.

Female↗
PubMed2002

[Nocturia. A common, but overlooked problem].

Nocturia is defined as waking at night to empty the bladder (1), irrespective of the number of times. Research has shown that it has a multifactorial aetiology and the need to wake up to urinate is probably because of an overproduction of urine or a reduced ability to store urine. Nocturia can occur at any age, but is particularly common in the elderly of both sexes. At present, both sufferers and physicians tend to consider it insignificant or a normal consequence of ageing, although it is not a trivial condition. Rising at night to urinate puts people at greater risk of falls (2), and has a detrimental effect on the quality of life, sleep patterns, and mortality (3). In young adults, the quality of life is particularly affected by persistent nocturia. Treatments (behaviour modification and pharmacological agents) are effective in many cases, although it is important to tailor treatment to the underlying pathophysiology.

Adult↗
PubMed2002

Short-term reproducibility of cystometry and pressure-flow micturition studies in healthy women.

AIMS: To evaluate the reproducibility of cystometry and pressure flow studies in women. We wanted to explore any clinically relevant effect of repeated, same-session cystometry. METHODS: Thirty healthy women with a mean age of 52 years were investigated with repeat medium-fill water cystometry and pressure-flow micturition studies in a single session. RESULTS: Large test-retest variability was noted, with wide limits of agreement. Of statistical significance was an increase of first desire (FD) and normal desire (ND), and a decrease in bladder opening pressure. Maximum cystometric capacity was unchanged. CONCLUSIONS: Although the nature of the conditioning effect of the first fill remains to be explored, the phenomenon could possibly be used for improved urodynamic diagnosis.

Adult↗