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Biomedical subjects

Guenter Germann

Publications and source records attributed to Guenter Germann.

6 recordsLinked to original sources
PubMed2005

Measuring levels of upper-extremity disability in employed adults using the DASH Questionnaire.

PURPOSE: The Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire is a standardized outcome measure that captures upper-extremity disability from the perspective of the patient and is used to study clinical outcomes in musculoskeletal disorders. To constitute a frame of reference for clinical values it is important for clinicians to be able to compare clinical DASH scores with those of nonclinical populations. We collected DASH data from a working population in Germany that was outside clinical considerations and used the data to identify disability levels among identified subgroups as a basis for future clinical comparisons. METHODS: We evaluated the DASH data using a convenience sample of 716 employed adults. Separate analyses were performed for each of the DASH scores, which were grouped according to age, gender, and type of vocational activity. RESULTS: The rank analysis of variance showed that statistically significant differences were found in Germany, differentiating between gender, age, and self-estimated vocational groups. Tests for interaction analyses of variance showed that increased disability was expressed as significantly higher mean DASH scores among older workers, female workers, and manual workers. CONCLUSIONS: This study provides comparative data for our clinical population and allows insight into current disability levels in a nonclinical population.

Adolescent↗
PubMed2004

Comparison of six methods for the assessment of ischemia-reperfusion injury in skeletal muscle following composite tissue allotransplantation.

Ischemia/reperfusion (I/R) injury is one of the factors determining tissue survival in replantation and transplantation surgery. However, more than 20 methods have been used to evaluate I/R injury in muscle. The aim of this study was to examine I/R injury in muscle tissue in a model of composite tissue allotransplantation (rat hindlimb transplantation), based on the analyses of six parameters: nitroblue tetrazolium staining (NBT); histology of the anterior tibial and extensor digitorum muscle; wet-to-dry weight ratio; serum potassium; and serum creatine kinase (CK)), in order to identify the most practicable and reliable outcome parameter. Results demonstrated that NBT staining and the wet/dry weight ratio are reliable tools for outcome measurement. The wet/dry weight ratio is the easiest to perform and the authors consider it to be useful for screening purposes. Histologic assessment shows areas of necrosis, but is not a reliable method for semi-quantitative evaluation. Serum potassium and CK levels were higher following transplantation, but they cannot be recommended for assessment purposes, as no significant correlation with other parameters was seen. These findings help further researchers in their selection of reliable outcome parameters to measure I/R injury in skeletal muscle.

Animals↗
PubMed2003

Restoration of thumb sensibility with the innervated first dorsal metacarpal artery island flap.

PURPOSE: This study investigated the quality of sensibility from innervated first dorsal metacarpal artery (FDMCA) island flaps in younger and older patients and evaluated the donor site morbidity at the index finger. METHODS: Twenty-five patients with an innervated FDMCA island flap to restore sensibility of the thumb were divided into groups according to age (>50 or <50 years). Sensory recovery and cortical reorientation were tested with Semmes-Weinstein monofilaments, a calibrated 2-point discrimination tester, and needle prick testing. Donor site morbidity was evaluated for range of motion, aesthetic appearance, pain, and problems with injuries. RESULTS: The mean age of the patients was 48.3 years and the mean follow-up period was 3 years. The 14 patients older than 50 years had a static 2-point discrimination (s2-PD) of 10.9 mm compared with 10.8 mm of the 11 patients younger than 50 years. The average loss of s2-PD of the flap compared with the donor area averaged 2.7 mm in all patients. Complete cortical reorientation occurred in 7 patients older than 50 years and in 5 patients younger than 50 years. Total loss of range of motion of all donor finger joints was 14 degrees (4.4%) compared with the contralateral index finger. Twenty-two patients were satisfied with the result. CONCLUSIONS: There were no age-related differences in the surgical results of the innervated FDMCA island flap and the donor site morbidity was negligible.

Adult↗
PubMed2003

Soft tissue coverage in devastating hand injuries.

Plastic surgical therapy of mutilating hand injuries represents a multifaceted task to the hand surgeon, where considerations about indication, timing, and structure of the soft tissue coverage play a major role in reconstruction. The concept of early primary reconstruction (including emergency procedures) and fast rehabilitation not only demands thoughtful tissue preparation but also mastering of a bandwidth of plastic surgical techniques. Systematic algorithms based on the reconstructive ladder help in decision making in the complexity of soft tissue coverage but have to be adjusted to the individual case profile. General considerations and strategic planning are explained and illustrated by three clinical cases.

Adult↗
PubMed2003

Free tissue transfer: an advanced strategy for postinfection soft-tissue defects in the upper extremity.

Surgical treatment of severe, necrotizing infections frequently leave compound defects that require complex reconstructive procedures. In the upper extremity, local flap coverage is limited because of the size of the lesions. Regarding the results of early microsurgical coverage of complex postinfectious defects of the lower extremity, the goal of this study was to evaluate the role of free tissue transfer in the treatment of severe infections in the upper extremity. Between 1994 and 1999, 24 patients with major defects as a result of severe necrotizing infections in the upper extremity underwent free tissue transfer. Parameters assessed included the success of infection control, flap survival rate, salvage of the extremity, and an outcome analysis by the Disability of Arm-Shoulder-Hand score and a visual analog scale. Patient age ranged from 17 to 75 years (average age, 50.8 years). Previous treatment of 11 patients in outlying hospitals included 4.2 operative procedures and a delay of admission to the authors' unit of 89 days. The average defect size after debridement was 10.0 x 14.4 cm. Twenty-four free flaps including 16 muscle or musculocutaneous flaps, 4 chimeric flaps from the subscapular system, and 4 osteocutaneous flaps were performed for reconstruction. The overall flap survival was 95.8%. One temporalis fascia flap (TPF) was lost as a result of vascular thrombosis, and three flaps underwent successful revision of the anastomoses. Eight patients required further minor surgical treatment. The Disability of Arm-Shoulder-Hand score yielded an average of 41.5 points, which represents a moderate impairment of activities of daily living. Visual analog scale assessment demonstrated an overall high satisfaction (9.5 points; range, 1-10 points). The data demonstrate that even in severe necrotizing infections resulting in complex acute or chronic defects, limb salvage and infection control can be achieved successfully with radical debridement and early free tissue transfer.

Adolescent↗