Loss of autonomy related to valproic acid intake.
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Aged, 80 and over↗
Biomedical subjects
Gilles Berrut
Publications and source records attributed to Gilles Berrut.
[Gait and dual-task: definition, interest, and perspectives in the elderly].
Walking is an automated rythmic motor behavior that is mostly controlled by subcortical brain regions. Automaticity implies that gait can be performed without attention. However, recent works highlight the involvement of attentional resources in gait, using a "dual-task" methodology in which performance on attention-demanding tasks such as spoken verbal response and walking is compared when they are performed separately and concurrently. Changes in gait patterns due to simultaneous performance of an attention-demanding task are interpreted as interference caused by competing demands for attentional resources involving the cortical level in gait control. Dual-task related gait changes are a new way to assess age-associated change in gait control. Furthermore, new screening tools of falling risk based on the dual-task paradigm have been developed, comparing walking performance alone to walking while performing a simultaneous attention-demanding task. However, the consistent prediction of falls by dual-task testing remains difficult. The recent availability and growing number of validated, user-friendly portable gait analysis systems allow simple objective gait measurement such as gait variability. The study of gait variability under dual-task represents a new challenge for the clinicians because high stride-to-stride variability is a powerful fall predictor in older adults. Because there is increasing evidence that age-related gait changes are associated with incidence of dementia, dual-task related gait changes could provide useful information about relationship between gait disorders and cognitive decline. Furthermore, dual-task could be a new approach of the gait disorders rehabilitation.
Accidental Falls↗
Executive functioning in normal aging: a study of action planning using the Zoo Map Test.
A particularly important aspect of executive functioning involves the ability to form and carry out complex plans, that is to say planning. This study aimed to investigate planning in 18 older and 16 younger normal participants using an ecological planning subtask derived from the Behavioural Assessment of the Dysexecutive Syndrome test battery, the "Zoo Map Test." There are two trials. The first trial consists of a "high demand" version of the subtask in which the participants must plan in advance the order in which they will visit designated locations in a zoo (formulation level). In the second, or "low demand" version, the participant is simply required to follow a concrete externally imposed strategy to reach the locations to visit (execution level). The two-way ANOVAs mainly showed more difficulties in elderly adults than in younger adults, more difficulties in formulation level than in execution level, and lastly a greater difference between formulation and execution in older participants than in younger adults. These results suggest that elderly participants have some problems developing logical strategies whereas they are able to execute complex predetermined plans.
Adult↗
Energy requirements are not greater in elderly patients suffering from pressure ulcers.
OBJECTIVES: To estimate energy requirements in diseased elderly patients with pressure ulcers (PUs). DESIGN: Open, case-control study. SETTING: University Hospital of Angers (France). PARTICIPANTS: Twenty-nine patients with PUs (Norton index risk=14.3+/-3.3) and 27 controls hospitalized for various diseases (Norton=13.9+/-3.3). MEASUREMENTS: Energy requirements were estimated using measured resting metabolic rate (RMR) and multiplied by 1.26 and 1.5 to range between minimal World Health Organization (WHO) requirements and those of adults undergoing light physical activity. Energy intakes were estimated using 3-day food weight records. Measured RMR was compared with the prediction equations of Harris-Benedict, WHO, and Schofield. RESULTS: Measured RMR did not differ between the two groups (P=.48), and was not related to grade or size of the PUs. The WHO equation (82 kcal/d, P=.006) and the Schofield formula (57 kcal/d, P=.05) slightly underestimated calculated RMR, but the Harris-Benedict equation (40 kcal/d, P=.13) accurately estimated it. Energy requirements therefore ranged between 1,536+/-340 kcal/d and 1,828+/-405 kcal/d, (25-30 kcal/kg body weight per day). Energy intake was lower than energy requirements by 176 to 479 kcal/d. CONCLUSION: Diseased elderly patients with PUs do not have greater energy expenditure, with their requirements suggested to range between 25 and 30 kcal/kg body weight per day. Malnutrition within this population is most likely the result of low energy intake.
Aged↗
The importance of good hydration for day-to-day health.
The role of hydration in the maintenance of health is increasingly recognized. Studies in healthy adults show that even mild dehydration impairs a number of important aspects of cognitive function such as concentration, alertness, and short-term memory. However, due to the lack of suitable tools for assessment of hydration status, the effects of hydration on other aspects of day-to-day health and well-being remain to be demonstrated.
Attention↗
Oral supplements differing in fat and carbohydrate content: effect on the appetite and food intake of undernourished elderly patients.
BACKGROUND & AIMS: Since fat, relative to other macronutrients, has low satiety and high energy density, it may have therapeutic application for supplementing energy intake. This study compared the effect of isoenergetic (1050 kJ) high fat or high carbohydrate oral supplements, given at breakfast, on the short-term appetite and energy intake in undernourished elderly subjects. METHODS: Sixteen hospitalised, undernourished (body mass index: 20 +/- 3 kg/m2), elderly (77 +/- 8 yr) people were randomly allocated to a control or 1 of 2 supplement groups [fat: carbohydrate: protein (% energy) was 70:25:5 or 25:70:5]. In each group, energy intake (24-h food consumption) and appetite (visual analogue scales) were assessed over 3 consecutive days. RESULTS: Mean energy intake significantly (P = 0.0035) increased following supplementation: high fat 6973 kJ/d, high carbohydrate 6906 kJ/d vs. control 6079 kJ/d but mean voluntary 24-h energy intake remained unaffected. Compared to controls, supplemented subjects experienced reduced hunger (P = 0.07) between breakfast and lunch, but showed no difference over the whole day (P = 0.55). CONCLUSIONS: Under these study conditions a 1050 kJ oral supplement, irrespective of macronutrient composition, does not cause voluntary short-term energy intake compensation in undernourished elderly people.
Administration, Oral↗
Short-term effect of a protein load on appetite and food intake in diseased mildly undernourished elderly people.
BACKGROUND & AIMS: Malnutrition is a risk factor for mortality and various morbidities in the elderly. A low-energy intake often prevails and therapeutic interventions include the administration of dietary supplements, sometimes rich in proteins. We have tested the hypothesis that a protein-rich supplement inhibits appetite and decreases voluntary food intake. METHODS: Twelve mildly undernourished (BMI 21.3 +/- 2.4 kg/m2) elderly (84 +/- 7.8 yr) diseased persons were each studied under 3 conditions, in which they were given in random order at breakfast, and on consecutive days: either no supplement, a 250 kcal, 20 g protein supplement or a 250 kcal, 3.5 g protein supplement. Hunger, fullness, and desire to eat sensations were monitored half-hourly from before breakfast until lunch, and hourly from lunch until dinner. Food intake was assessed by weighing food before and after meals. Total energy and macronutrient intakes were calculated over 24 h. RESULTS: Both supplements increased energy intake (+185 kcal protein supplement, +176 kcal). Protein supplementation induced a net 17 g increase in protein intake (P < or = 0.0003). Neither supplement affected spontaneous food intake at lunch, dinner, or over the 24 h. Protein supplementation significantly depressed appetite in the breakfast to lunch period. CONCLUSION: A 250 kcal, 20 g protein supplement depresses hunger without affecting food intake in elderly diseased mildly undernourished persons.
Aged↗
Reference data for normal subjects obtained with an accelerometric device.
We collected gait analysis data for 282 healthy adults and elderly people (144 women and 138 men aged 20-98) using an accelerometric device, whose reproducibility (intra-tester and inter-testers) has been validated for gait studies. The subjects walked at their own speed along a corridor (40 m). Stride frequency (SF) (after correction for height), step symmetry (Sym), stride regularity (Reg), and vertical harmonic (slope) were all independent of age or gender. The median-lateral harmonic (slope) (MSH) was influenced by gender, but not by age. Other variables (walking speed, stride length (SL), cranial-caudal activity and raw accelerations at heel contact, mid-stance and initial push-off) were dependent on gender and age. They were higher in men than in women, and began to decrease during the sixth decade in men and the seventh decade in women. The raw acceleration at foot flat was independent of gender but was influenced by age. This accelerometric device is easy to use and requires no specialized equipment and could be used to analyze walking in clinical practice.
Acceleration↗
Estimation of calorie and protein intake in aged patients: validation of a method based on meal portions consumed.
BACKGROUND: Malnutrition is highly prevalent in hospital, mainly in geriatric, wards. Weight loss results from a negative energy balance, a situation where energy intake does not match energy requirements. Estimates of patient calorie consumption are not performed routinely because of technical difficulties. We performed three studies to investigate the meal-portion (MP) method as a tool for estimating calorie and protein intakes in clinical situations. METHODS: The MP method was designed to estimate calorie and protein consumption from the portion of the food items actually eaten by the patient, which is evaluated at the time plates and dishes are cleared away. Study 1 tested accuracy of the MP method in 50 meals by comparison to food weighing. Study 2 evaluated the validity of estimates obtained by a physician, a member of nursing staff, and a dietician in 30 elderly patients. Study 3 evaluated the robustness and feasibility of the method by comparing estimates obtained by nursing staff (after 1 year of practice with no additional training) and that of a dietician. RESULTS: Comparison of estimates and true values (obtained by weighing) showed a mean difference of -2 kcal/-0.8 g of protein from evaluations of one-half portions of food (50 meals) and -7 kcal/-1.0 g of protein from one-quarter portions of food; the difference was only significant for protein and one-quarter portions (p =.03). When evaluations were performed by observers of different professional categories (nursing staff, physicians, and dieticians) on actual meals consumed by 30 elderly people afflicted with disease, no statistical differences were shown. This interobserver agreement remained, regardless of the cognitive or physical status of the patient. A third study, performed after 1 year of no additional training, showed that the MP method is robust, but prone to clerical errors. CONCLUSIONS: Valid estimates of calorie and protein consumption can be obtained with the MP method, quoting in one-half portions. Quality controls are required both at the food production site (to avoid propagation of errors arising from food composition) and in data collection (to eliminate clerical mistakes). These results suggest that the MP method could be a tool for estimating calorie and protein intakes in many clinical situations.
Aged↗