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Gertraud Heinz-Peer

Publications and source records attributed to Gertraud Heinz-Peer.

12 recordsLinked to original sources
PubMed2007

Imaging of adrenal masses.

PURPOSE OF REVIEW: This review aims to outline recent developments in adrenal imaging and characterization. Controversies in the management of adrenal incidentalomas will be addressed. RECENT FINDINGS: Evaluation of density readings on unenhanced computed tomography and on contrast-enhanced delayed series has tremendously improved the characterization of adrenal masses. Attenuation measurements may, however, vary between different scanner types and may also be influenced by patient factors and the scanning technique. Evaluation of the mean percentage washout for adrenal masses on delayed enhanced computed tomography series is independent of such factors and allows the characterization of adrenal lesions with high sensitivity and specificity. In magnetic resonance imaging, dynamic gadolinium-enhanced and chemical-shift techniques have significantly improved the characterization of adrenal masses. Nuclear medicine studies prove to be useful adjuncts. Controversial reports have been published on the role of positron emission tomography/computed tomography in adrenal imaging. Adrenal venous sampling may allow differentiation of aldosteronoma and idiopathic hyperaldosteronism. SUMMARY: Recent developments in adrenal mass imaging have improved the characterization of adrenal mass lesions. The need for histology sampling of incidentally discovered adrenal masses has been significantly reduced due to the high specificity of these new techniques. Controversies still exist regarding the optimal strategy for hormonal screening of a patient with an incidentally detected adrenal mass.

Adrenal Gland Neoplasms↗
PubMed2005

Unenhanced multi-detector row CT in patients suspected of having urinary stone disease: effect of section width on diagnosis.

PURPOSE: To assess prospectively the effect of section width in multi-detector row computed tomographic (CT) evaluation of patients with acute flank pain who are suspected of having or known to have urinary stone disease. MATERIALS AND METHODS: This study was approved by the ethics committee of the authors' university, and written informed consent was obtained from all patients. One hundred forty-seven patients (age range, 11-101 years; mean, 51.4 years +/- 18.7 [standard deviation]) suspected of having urinary stone disease underwent unenhanced multi-detector row CT. CT was performed with four detector rows, a section thickness of 1.0 mm, an effective tube current-time product of 100 mAs, and a tube voltage of 120 kVp (CT dose index, 11.4 mGy). From these data, three sets of transverse images were reconstructed with section widths of 1.5, 3.0, and 5.0 mm and approximately 50% of overlap each. Scans were evaluated in varying random orders by two radiologists for the number, size, and location of uroliths and nephroliths and for the presence of phleboliths, renal cysts, and secondary signs of obstruction. The significance of differences between the numbers of detected calcifications and the numbers of associated abnormalities on the scans obtained with varying section widths was tested with the McNemar test at a P level of less than .05. Spearman rho rank correlation coefficients were calculated to assess the correlation between the presence of uroliths and the presence of secondary signs. RESULTS: Uroliths were found in 72 of 147 (49.0%) patients, and nephroliths were found in 16 patients (10.9%). There was no significant difference between section widths of 1.5 and 3.0 mm with regard to the number of detected stones (264 uroliths and 61 nephroliths for both protocols). Transverse sections 5.0-mm wide revealed significantly fewer uroliths (n = 231; P < .001) and nephroliths (n = 47; P < .016). The final diagnosis was changed in four of 72 patients. All missed renal and ureteral stones measured less than 3 mm in diameter. CONCLUSION: Overlapping 3-mm sections are sufficient for the detection of urinary stone disease. Small calculi (<3 mm) may be missed on 5.0-mm-thick sections.

Adolescent↗
PubMed2004

Applicability of laparoscopic adrenalectomy in a prospective study in 150 consecutive patients.

HYPOTHESIS: Within a decade, laparascopic adrenalectomy has become the new "gold standard" for the surgical treatment of most adrenal lesions. Designed as a single-center project focused on patients with adrenal lesions, this study should provide an indication of the number of patients requiring surgery who can safely undergo laparoscopy, after consideration of such selection criteria as tumor size and benign or malignant lesion status at magnetic resonance imaging. Furthermore, the access-related complications were analyzed. DESIGN: According to a prospective protocol, 150 consecutive patients selected for adrenal surgery were assigned to transperitoneal endoscopic or open adrenalectomy. SETTING: University hospital section of endocrine surgery. RESULTS: One hundred two patients (68%) were selected for a laparoscopic approach that had to be converted to open surgery in 5 patients (5%). Two malignant cortisol-secreting lesions were operated on laparoscopically because of their small size and benign appearance at magnetic resonance imaging. During histological examination, 14 (29%) of 48 patients assigned to transperitoneal open adrenalectomy had lesions deemed malignant (16 [11%] of 150 patients). The laparoscopic group had significantly fewer complications (9%) than did the open group (21%; P =.04). CONCLUSIONS: By applying defined selection criteria for the treatment of adrenal lesions, transperitoneal endoscopic adrenalectomy can be a safe procedure and may be performed in at least two thirds of patients. The choice of endoscopic or open approach in larger tumors should depend on the results of preoperative imaging studies and the endocrine surgeon's experience in endoscopic adrenal surgery.

Adrenal Gland Neoplasms↗
PubMed2004

Improved detection of focal liver lesions at MR imaging: multicenter comparison of gadoxetic acid-enhanced MR images with intraoperative findings.

PURPOSE: To evaluate the safety and efficacy of gadoxetic acid disodium-enhanced magnetic resonance (MR) imaging for the detection of focal liver lesions, with results of histopathologic examination and/or intraoperative ultrasonography used as a standard of reference. MATERIALS AND METHODS: One hundred sixty-nine patients who were known to have or suspected of having focal liver lesions and were scheduled for liver surgery were included in this study. Results in 131 patients could be included in the efficacy analysis. MR imaging was performed before and immediately and 20 minutes after bolus injection of 0.025 mmol/kg of the liver-specific hepatobiliary contrast agent gadoxetic acid. T1-weighted gradient-echo (with and without fat saturation and including dynamic data sets) and T2-weighted fast spin-echo/turbo spin-echo sequences were performed. All images were evaluated on site and by three independent and blinded off-site reviewers. Lesion matching based on the standard-of-reference results was performed. Differences in lesion detection with precontrast and with postcontrast MR images were assessed with the two-sided Wilcoxon signed rank test. RESULTS: Gadoxetic acid was well tolerated. In the on-site review, the number of patients in whom all lesions were correctly matched increased from 89 of 129 patients at precontrast MR imaging to 103 of 129 patients at postcontrast MR imaging. In the off-site evaluation, the number of patients in whom all lesions were correctly matched and the corresponding sensitivity values increased from 72 (55.8%), 68 (52.7%), and 66 (51.2%) with the precontrast images to 88 (68.2%), 69 (53.5%), and 76 (58.9%) with the postcontrast images for readers 1, 2, and 3, respectively. Two of the three blinded readers showed a statistically significant difference in lesion detection between precontrast and postcontrast MR imaging (P <.001 and P =.008). A large number of additionally correctly detected and localized lesions were smaller than 1 cm. CONCLUSION: MR imaging with gadoxetic acid is safe and improves lesion detection and localization.

Adult↗
PubMed2003

[Imaging of tumours of the adrenal gland].

For differentiation of benign and malignant adrenal lesions, sensitivities and specificities of 85-100% can be reached by unenhanced computed tomography (CT)-methods, chemical shift techniques in magnetic resonance imaging (MRI), delayed enhanced CT-techniques, and by evaluation of wash-out curves in contrast enhanced CT or MRI. An increasing number of adrenal lesions that are detected on imaging studies for indications unrelated to the adrenals can be immediately characterized by delayed series nowadays. According to excellent results of CT and MRI in characterization of adrenal masses, the indications for fine needle aspiration biopsy have already regressed as well as complications associated with this invasive technique.

Adenoma↗
PubMed2002

Can dynamic gadolinium-enhanced magnetic resonance imaging with chemical shift studies predict the status of adrenal masses?

Endoscopic adrenalectomy represents the new gold standard in the surgical treatment of benign adrenal lesions up to 6 cm. In some cases lesions larger than 10 cm have been removed laparoscopically to offer the patient the advantages of the minimally invasive technique. The larger the diameter of an adrenal lesion, the greater the probability of malignancy. In a prospective study 130 consecutive patients (88 women, 42 men; mean age 47.8 years) with 137 adrenal lesions earmarked for surgery underwent preoperative gadolinium-enhanced magnetic resonance imaging (MRI) with chemical shift studies (CSS). The aim of this study was to predict the status (benign, borderline, malignant) of adrenal lesions by MRI irrespective of tumor size. There were 14 patients with malignant tumors, 3 had borderline tumors (epithelial tumors with high malignant potential), and the remaining 120 had benign adrenal lesions. Five malignant lesions (36%) had a diameter < 6 cm. MRI correctly predicted 11 of 14 malignant tumors (1 malignant pheochromocytoma and 2 adrenocortical carcinomas had false-negative results), 117 of 120 benign lesions, and 2 of 3 borderline lesions. All but two malignant tumors were operated on using open surgery; 82 (68%) of 120 benign adrenal lesions were treated using the transperitoneal laparoscopic approach. Tumor size alone is not suitable for predicting the status of adrenal lesions. Dynamic gadolinium-enhanced MRI with CSS can predict the status of at least 95% of adrenal lesions. Tumors> 6 cm classified as benign by preoperative MRI may be removed laparoscopically by endocrine surgeons experienced in endoscopic adrenalectomy.

Adenoma↗
PubMed2002

Surgical strategy in adrenal masses.

OBJECTIVE: Endoscopic adrenalectomy represents the "New Golden Standard" in the surgical treatment of benign adrenal lesions up to 6 cm. Open adrenalectomy is recommended for patients with suspected malignant disease and tumors larger than 6 cm. METHODS AND MATERIAL: The surgical technique of trans- and retroperitoneal adrenalectomy is described. Reviewing literature the importance of the endoscopic approach and its role in the surgical treatment of adrenal lesions is analyzed. RESULTS: As in open adrenalectomy different endoscopic approaches to the adrenals were developed: adrenal tumors can be removed endoscopically using a transperitoneal (patient in a supine or lateral decubitus position) or extraperitoneal route (patient in a lateral decubitus or prone position). Reviewing literature the endoscopic transperitoneal adrenalectomy is documented in 1425 patients. 4.6% (66 patients) had to be converted to an open procedure. Five hundred and forty-four tumors were removed by an extraperitoneal access. The conversion rate was 4.4% (24 patients). CONCLUSION: The basis of excellent results are careful patient selection, evaluation and preoperative preparation in a center with experience in the open techniques and at least 20 endoscopic adrenalectomies per year.

Adrenal Gland Neoplasms↗
PubMed2002

How accurate is MR imaging in characterisation of adrenal masses: update of a long-term study.

OBJECTIVE: The purpose of this study was to update a long-term study that evaluates the accuracy of MR imaging in the characterisation of adrenal tumours. In all patients, MR imaging findings were correlated with histopathologic results. PATIENTS: In 204/560 patients who underwent MR imaging for characterisation of an adrenal mass, histopathologic results were available. The final study group consisted of 229 adrenal masses in 204 patients. MR imaging was performed using T2-weighted fast spin-echo imaging and unenhanced and gadolinium-enhanced T1-weighted spin-echo imaging in all patients. In addition, chemical shift imaging was performed in 182 patients and dynamic gadolinium-enhanced studies in 198 patients. Chemical shift images and dynamic studies were qualitatively assessed. All images were reviewed by an experienced investigator (Gertraud Heinz-Peer) who was blinded to the clinical history and the results of prior imaging studies. RESULTS: The sensitivity of MR imaging for the differentiation of benign and malignant adrenal masses was 89%, the specificity 99%, and the accuracy was 93.9%. This results in a positive predictive value (PPV) of 90.9% and a negative predictive value (NPV) of 94.2%. These results are comparable to the data published previously by our study group with a lower number of cases. CONCLUSION: Large study numbers show that MR imaging is a reliable method in characterisation of benign and malignant adrenal masses. Since laparoscopic adrenalectomy has become the new gold standard in the surgical treatment of benign adrenal lesions, the high accuracy of MR imaging in characterisation of those lesions offers even patients with large adrenal masses (>5 cm) the advantages of the minimally invasive technique.

Adenoma↗
PubMed2002

Functional reconstruction and minimally invasive techniques.

Recent years have seen notable advances in imaging technologies. Three-dimensional computer-rendered techniques with rapid image acquisition have led to the development of virtual reality imaging. Virtual reality imaging allows interactive intraluminal navigation through any hollow viscus, simulating conventional endoscopy. This technique of virtual endoscopy has been applied to many organs, including the urinary tract. Virtual reality endoscopy is beginning to challenge the gold standard of conventional endoscopic evaluation. Recent advances in laparoscopic surgery are largely attributable to technological improvements in imaging equipment. Laparoscopic ultrasound has become a common adjunct in laparoscopic surgery. In particular, advances in video cameras and digital imaging technology have decreased the steep learning curve associated with laparoscopic procedures. Telerobotic systems offer several advantages to laparoscopic surgery, such as all six degrees of freedom, dexterity enhancement, tremor filtering, and stereovision. In addition, technological breakthroughs allow many procedures to evolve from open operations involving lengthy hospital stays to imaging-guided minimally invasive procedures performed on an outpatient basis. Finally, Internet-based imaging is changing the way in which urology services are delivered, by allowing rapid communication between remote locations.

Cystoscopy↗
PubMed2002

[Prostatic carcinoma: current status of diagnostic imaging].

Prostate carcinoma showed a strong increase in industrial countries and today it is the second common cause of cancer related death. Prostate specific antigen allows early detection of prostate cancer, US-guided biopsy is employed for proof of diagnosis. The role of imaging has been discussed very contrarily. However, different options for treatment of prostate cancer and last but not least technological advances of different imaging modalities seem to reassess the role of imaging in prostate cancer.

Biopsy, Needle↗