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Biomedical subjects

Gerhard W Hacker

Publications and source records attributed to Gerhard W Hacker.

3 recordsLinked to original sources

Biomedical evidence of influence of geopathic zones on the human body: scientifically traceable effects and ways of harmonization.

BACKGROUND: Empiric knowledge of the existence of geopathic zones ('water veins' etc) is probably as old as humankind. It has often been tried to experimentally detect direct influences on the body. However, so far, there have been no publications in accepted biomedical journals. The target of this study was to verify influences of 2 different zones above ground on the human body and to test a device for which pilot studies have indicated a potential harmonizing effect in this context. MATERIALS AND METHODS: Using a randomized, non-clinical, double-blinded trial design, 52 persons were tested with a gas discharge visualization (GDV) system whilst staying on 2 zones with or without the Geowave device (Geowave-Research, Salzburg, Austria). The 2 zones investigated had been dowsed by experienced professional dowsers and labeled with black dots in a non-persuasive manner, thereby blindly representing areas of geopathy or more neutral zones. The main analytical parameter was the GDV glow image area (area of glow). Complementary calculated parameters were spatial fractality, corona projections and corona diagrams. RESULTS: In the geopathic zone, the detected areas of glow were statistically significantly smaller than in the more neutral zone. With the Geowave blindly mounted in an adjacent room of the above story, a marked increase of the glow image area was found in both zones. The corona projections showed well-recognizable points of body energy deficits in the geopathic zone, mostly associated with the lymphatic system, the cardiovascular system and the pineal gland, which were -- to a distinctly lesser degree -- also present in the more neutral zone. The device tested yielded compensation or harmonization in both zones in most of the test persons. CONCLUSION: The significant differences in the physical area of glow parameter, which were also noticed for the complementary parameters analyzed, lead to the conclusion that the 2 different zones within the same room (geopathic vs. more neutral zone) exerted different influences on the human body, which may have caused a geopathic stress phenomenon. As a result, individually different retardation of the immune system and other organs may occur. The device tested in both zones showed harmonizing effects, which may help to compensate some influences of geopathy and possibility also superimposed stressors derived from certain other sources, such as technical electromagnetic fields.

Adolescent↗

Decrease of mitochondrial DNA content and energy metabolism in renal cell carcinoma.

To elucidate the relationship between tumor genesis and the mitochondrial energy metabolism in renal neoplasms, we studied three individual enzyme activities of the oxidative phosphorylation, two components of the Krebs cycle and the mitochondrial DNA content of renal carcinomas including 29 conventional, five papillary, two unclassified carcinomas with sarcomatoid features and one collecting duct carcinoma. A significant reduction of all mitochondrial enzyme activities including complex V, as well as of the mitochondrial DNA content was detected in 34 of 37 renal carcinoma tissues as compared with control kidney. Mitochondrial enzyme activities and mitochondrial DNA levels were not statistically different between the conventional, papillary and unclassified sarcomatoid type of renal carcinoma and did not correlate with tumour grade, metastasis, ploidy and proliferative activity as determined by Ki-67 staining. Taken together, our data indicate that a co-ordinated down-regulation of all components necessary for mitochondrial energy metabolism occurs in most renal carcinomas as an early event in carcinoma formation, which does not change with progression of the disease.

Adult↗

Neuroendocrine cell markers for pancreatic islets and tumors.

The authors review the application of a variety of neuroendocrine cell markers to identify pancreatic islet cells and tumors. In the past, several empiric histochemical techniques had been used to demonstrate neuroendocrine cells, particularly the Grimelius argyrophilic stain. The development of immunohistochemistry made it possible to demonstrate specific cell products such as regulatory peptides, thus allowing the classification of pancreatic neuroendocrine tumors with a view to clinical symptoms. However, it is not always possible to visualize regulatory peptides in these tumors. It is therefore important to use broad-spectrum neuroendocrine cell markers to identify the neuroendocrine nature. These markers are proteins localized in the secretory granules (core- or membrane-related), in the cytosol, or in the cellular membrane. The markers most commonly used in routine histopathology are the secretory granule proteins chromogranin A and synaptophysin and the cytosolic enzyme neuronspecific enolase. Other new markers (e.g., synaptic vesicle protein 2) are of general diagnostic value. Region-specific antibodies to chromogranin A can be valuable in differentiating between benign and malignant neuroendocrine tumors. Some markers may be related to the functioning characteristics of pancreatic neuroendocrine tumors, such as prohormone convertases. In addition, markers giving further complementary information have been identified, such as five somatostatin receptor subtypes, the expression of which varies markedly in pancreatic neuroendocrine tumors. Antibodies against all somatostatin receptor subtypes are now commercially available, and immunohistochemical investigation of its expression should be routinely applied when considering treatment with somatostatin analogs.

Biomarkers↗