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Biomedical subjects

George M Murray

Publications and source records attributed to George M Murray.

3 recordsLinked to original sources
PubMed2005

Synthesis of vinyl-substituted beta-diketones for polymerizable metal complexes.

[reaction: see text] Polymerizable beta-diketones for application to metal ion coordination have been prepared and characterized. Bromine-substituted beta-diketones were synthesized under Claisen-Schmidt-type condensation conditions. Vinyl groups were substituted for the halide by one of two types of Heck coupling with high-pressure ethylene. The type of Heck coupling employed was dictated by the thermal sensitivity of the substrate. Seven vinyl-substituted beta-diketones were synthesized, including several new ones, by this method. The beta-diketones were characterized by GC-MS, FT-NMR, FT-IR, and microanalysis.

Journal Article↗
PubMed2005

Selective photo-reduction of N-nitroamines combined with micellar electrokinetic chromatography and laser fluorimetric detection.

N-nitroso compounds (NOC) are potent carcinogens. Reliable methods for the analysis of volatile carcinogenic NOC are well established; however selective and sensitive methods for routine analysis of thermally unstable, ionic or non-volatile NOC are still needed. For this purpose, a method based on micellar electrokinetic chromatography (MEKC) with laser induced fluorescence (LIF) detection is described for the simultaneous determination of a broad range of N-nitroso compounds. In this procedure, the nitroso group is photolytically cleaved from the NOC to yield the corresponding amine. The amines are then derivatized with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl), identified and quantified using MEKC-LIF. For the standard mixture of NOC, this method has good sensitivity and a large dynamic range. The detection limit provided by the method is 9 ppb for N-nitrosopyrrolidine.

4-Chloro-7-nitrobenzofurazan↗