Nonconventional catalysts for isotactic propene polymerization in solution developed by using high-throughput-screening technologies.
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Journal Article↗
Biomedical subjects
Gary M Diamond
Publications and source records attributed to Gary M Diamond.
The modified cognitive constructions coding system: reliability and validity assessments.
The cognitive constructions coding system (CCCS) was designed for coding clients' expressed problem constructions on four dimensions: intrapersonal-interpersonal, internal-external, responsible-not responsible, and linear-circular. This study introduces, and examines the reliability and validity of a modified version of the CCCS-a version that involves coding clients' problem constructions at the level of speech turn. Results indicate that the modified CCCS generated reliable ratings of clients' problem constructions in 15 sessions of family therapy. Validity was established by comparing 71 subjects' own ratings of over 250 self-generated problem constructions to the ratings of trained CCCS coders. The modified CCCS allows for identifying moment-to-moment changes in clients' problem constructions and, ultimately, examining the impact of therapist behaviors on such changes.
Adolescent↗
Psychological symptoms and drug use severity among Israeli adolescents presenting for outpatient drug abuse treatment.
The objective of this study was to assess the rates of externalizing and internalizing symptoms, and the relation between psychological symptoms and drug use severity, among 117 Israeli adolescents presenting for outpatient drug abuse treatment. Psychological symptoms were assessed via both adolescent self-report and parent report. Drug use was assessed using both adolescent self-report and urinalysis. Results showed that 58% of the sample evidenced clinical levels of psychological symptoms, with girls evidencing higher rates of externalizing and mixed symptomatology than boys. Parents' report of adolescents' internalizing symptoms predicted severity of drug use. These findings suggest that treatment for this population should be multidimensional, and address not only drug use per se, but also psychological risk factors.
Adolescent↗
Adolescent and parent alliance and treatment outcome in multidimensional family therapy.
In this study, the authors examined the relation between adolescent and parent therapeutic alliances and treatment outcome among 65 substance-abusing adolescents receiving multidimensional family therapy. Observer ratings of parent alliance predicted premature termination from treatment. Observer ratings, but not self-report, of adolescent alliance predicted adolescents' substance abuse and dependency symptoms at posttreatment, as well as days of cannabis use at 3-month follow-up. The association between adolescent alliance and substance abuse and dependency symptoms at posttreatment was moderated by the strength of the parent alliance. Results reveal the unique and interactive effects of the 2 alliances on treatment outcome and emphasize the need for a systemic and well-articulated approach to developing and maintaining the multiple alliances inherent to family therapy.
Adolescent↗
Perceived parental care and control among Israeli female adolescents presenting to emergency rooms after self-poisoning.
Levels of perceived parental care and control among 24 female Israeli adolescents presenting at emergency rooms after a self-poisoning act of low lethality were compared to those found among 23 non-self-harming, community controls. Adolescents' perceived levels of parental care and control were measured via both adolescents' self-report and independent objective ratings of adolescents' unconstrained descriptions of their parents. Adolescents also completed a standardized psychological symptom checklist. Data from both measurement perspectives indicated that adolescents evidencing self-poisoning behavior perceived their mothers as less caring and more controlling--a parenting style characterized as "affectionless control"--than did the comparison group. Independent ratings of adolescents' descriptions of their parents suggested that those exhibiting self-poisoning also perceived their fathers as less caring. These effects were not moderated by level of psychological symptoms. The findings are consistent with those from previous research showing an association between perceived parental care and control and various self-harming behaviors among adolescents, and highlight the need for research on the potential clinical utility of employing family-based, attachment-promoting psychosocial interventions with this population.
Adolescent↗
A fully integrated high-throughput screening methodology for the discovery of new polyolefin catalysts: discovery of a new class of high temperature single-site group (IV) copolymerization catalysts.
For the first time, new catalysts for olefin polymerization have been discovered through the application of fully integrated high-throughput primary and secondary screening techniques supported by rapid polymer characterization methods. Microscale 1-octene primary screening polymerization experiments combining arrays of ligands with reactive metal complexes M(CH(2)Ph)(4) (M = Zr, Hf) and multiple activation conditions represent a new high-throughput technique for discovering novel group (IV) polymerization catalysts. The primary screening methods described here have been validated using a commercially relevant polyolefin catalyst, and implemented rapidly to discover the new amide-ether based hafnium catalyst [eta(2)-(N,O)[bond](2-MeO[bond]C(6)H(4))(2,4,6-Me(3)C(6)H(2))N]Hf(CH(2)Ph)(3) (1), which is capable of polymerizing 1-octene to high conversion. The molecular structure of 1 has been determined by X-ray diffraction. Larger scale secondary screening experiments performed on a focused 96-member amine-ether library demonstrated the versatile high temperature ethylene-1-octene copolymerization capabilities of this catalyst class, and led to significant performance improvements over the initial primary screening discovery. Conventional one gallon batch reactor copolymerizations performed using selected amide-ether hafnium compounds confirmed the performance features of this new catalyst class, serving to fully validate the experimental results from the high-throughput approaches described herein.
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Attachment-based family therapy for depressed adolescents: programmatic treatment development.
Few effective psychosocial treatment models for depressed adolescents have been developed, let alone ones that use the developmentally potent context of the family as the focus of intervention. Attachment-based family therapy (ABFT) is a brief, manualized treatment model tailored to the specific needs of depressed adolescents and their families. Attachment theory serves as the main theoretical framework to guide the process of repairing relational ruptures and rebuilding trustworthy relationships. Empirically supported risk factors for depression are the primary problem states that therapists target with specific treatment strategies or tasks. Parent problem states include criticism/hostility, personal distress, parenting skills, and disengagement. Adolescent problem states include motivation, negative self-concept, poor affect regulation, and disengagement. Intervention tasks include relational reframing, building alliances with the adolescent and with the parent, addressing attachment failures, and building competency. A small, randomized clinical trial provides initial support for the model. Several process research studies, using both qualitative and quantitative methods, have helped refine the clinical guidelines for each treatment task. ABFT is a promising new treatment for depressed adolescents and more research on it is warranted.
Adolescent↗
Triple tandem catalyst mixtures for the synthesis of polyethylenes with varying structures.
Tandem catalysis in a single medium presents challenges and opportunities for creating novel synthetic protocols. Thus far, only two homogeneous catalysts have been used in tandem. Herein, we report that it is possible to coordinate the action of three well-defined homogeneous catalysts to produce a wide range of branched polyethylenes from a single monomer. Thus, ([(eta(5)-C(5)Me(4))SiMe(2)(eta(1)-NCMe(3))]TiMe)(MeB(C(6)F(5))(3)) (1), [(C(6)H(5))(2)PC(6)H(4)C(OB(C(6)F(5))(3))O-kappa(2)P,O]Ni(eta(3)-CH(2)C(6)H(5)) (2), and ((H(3)C)C[N(C(6)H(5))]C[O-B(C(6)F(5))(3)][N(C(6)H(5))]-kappa(2)N,N)Ni(eta(3)-CH(2)C(6)H(5)) (3) react with ethylene to produce branched polyethylene with structures that cannot be obtained using a single- or a two-component catalyst combination. The properties of the polyethylene depend on the ratio of the three catalysts. High-throughput screening techniques proved essential for optimizing reaction conditions and for probing how the catalyst composition influences the polymer properties.
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High-throughput approaches for the discovery and optimization of new olefin polymerization catalysts.
The discovery of new olefin polymerization catalysts is currently a time-intensive trial-and-error process with no guarantee of success. A fully integrated high-throughput screening workflow for the discovery of new catalysts for polyolefin production has been implemented at Symyx Technologies. The workflow includes the design of the metal-ligand libraries using custom-made computer software, automated delivery of metal precursors and ligands into the reactors using a liquid-handling robot, and a rapid primary screen that serves to assess the potential of each metalligand-activator combination as an olefin polymerization catalyst. "Hits" from the primary screen are subjected to secondary screens using a 48-cell parallel polymerization reactor. Individual polymerization reactions are monitored in real time under conditions that provide meaningful information about the performance capabilities of each catalyst. Rapid polymer characterization techniques support the primary and secondary screens. We have discovered many new and interesting catalyst classes using this technology.
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Attachment-based family therapy for depressed adolescents: a treatment development study.
OBJECTIVE: To design a treatment manual and adherence measure for attachment-based family therapy (ABFT) for adolescent depression and to collect pilot data on the treatment's efficacy. METHOD: Over a period of 2 years, 32 adolescents meeting criteria for major depressive disorder (MDD) were randomly assigned to 12 weeks of ABFT or a 6-week, minimal-contact, waitlist control group. The sample was 78% female and 69% African American; 69% were from low-income, inner-city communities. RESULTS: At post-treatment, 81% of the patients treated with ABFT no longer met criteria for MDD, in contrast with 47% of patients in the waitlist group. Mixed factorial analyses of variance revealed that, compared with the waitlist group, patients treated with ABFT showed a significantly greater reduction in both depressive and anxiety symptoms and family conflict. Of the 15 treated cases assessed at the follow-up, 13 patients (87%) continued to not meet criteria for MDD 6 months after treatment ended. CONCLUSIONS: ABFT appears to be a promising treatment and worthy of further development.
Adolescent↗