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Biomedical subjects

G den Otter

Publications and source records attributed to G den Otter.

At least 19 recordsLinked to original sources
PubMed1987

The value of 99mTc macroaggregated albumin lung perfusion scanning in the prediction of postpneumonectomy function and pulmonary artery pressure.

99mTc macroaggregated albumin lung perfusion scans were performed with assessment of pulmonary hemodynamics in 14 male patients with a centrally located lung tumor, subjected to pneumonectomy. In 7 patients perfusion of the affected lung was less than one third of total perfusion. However, all tumors were resectable. Results show that predictive value of the perfusion scan was significant (p less than 0.02) with regard to forced expiratory volume in the first second (FEV1, r = 0.80). A fair but not significant correlation existed in the prediction of vital capacity (VC, r = 0.64) and total lung capacity (TLC, r = 0.71). No correlation was found between perioperative change in mean pulmonary artery pressure (MPAP) and either relative radionuclide uptake of the affected lung or predicted FEV1. So, the lung perfusion scan cannot be used in preoperative estimation of postoperative MPAP.

Aged↗
PubMed1985

Reconstruction of large bone defects with calcium phosphate ceramics--an experimental study.

The aim of the present study is to evaluate the bone-defect-repairing capacity of dense hydroxyapatite compared with 40% macroporous hydroxyapatite in a weight-bearing model. The experiment consisted of the production of a relatively large mid-diaphysary defect in the left femur of 18 mongrel dogs. Cylindrical and semicylindrical hydroxyapatite implants were placed in these bone defects in order to restore continuity. The biocompatibility of implanted material has been studied physiologically, by radiographs and scintigraphs, by histology and finally by biomechanical tests. The normal weight-bearing of the operated limb restored in three weeks time. There were two mechanical failures in dense cylindric implants and two in porous cylindric implants. Radiographically, no evidence was found of degradation of porous or dense implants. Radionuclide bone imaging to assess osseous changes at the site of implants, showed intense radionuclide accumulation in all recordings of porous implants up to two years after implantation, in contrast to dense implant recordings. Histologically, there was no evidence of bioresorption. The implants were in direct contact with normal bone tissue. The pores were filled by calcified bone. There were no differences between porous and dense implants concerning the biocompatibility of hydroxyapatite.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1979

Pulmonary circulation pressures in surgical patients. The use of the Swan-Ganz catheter.

Experiences with the Swan-Ganz catheter in 'high risk' surgical intensive care patients are described. After description of the catheter and catheterization technique, normal values from the literature are presented. Attention is drawn to the occurrence of artefacts in the pressure curve, which can lead to the inference of faulty results from the measurements. Attention is also drawn to the effect of intrathoracic pressure on pulmonary vascular pressures. A review of possible complications is given, with recommendations how these may be avoided or at least reduced to a minimum. The authors' material is used to demonstrate the value of the catheter, showing that the CVP is not always a trustworthy parameter for hemodynamic monitoring. The conclusion is drawn that the 'high risk' patient on the surgical intensive care unit gains from the use of the Swan-Ganz catheter.

Blood Pressure Determination↗
PubMed1979

Case report: ischemic enteritis in a patient with Candida albicans infection.

A case is reported of a 64-year old man with Candida albicans sepsis of pulmonary origin. It was complicated by a hemorrhagic ischemic enteritis that made it necessary to resect 2 1/2 m of small bowel. The specimen contained many pseudohyphae and yeast cells in the layers of the wall, especially in the necrotic areas. The superior mesenteric artery and its branches were patent and not occluded by infected thrombotic material, as has been described in another case of necrotizing enteritis accompanying Candida albicans sepsis. The pathogenesis and treatment of the ischemic enteritis in this case are discussed.

Candidiasis↗
PubMed1978

Curative and palliative surgical treatment of pancreaticoduodenal adenocarcinoma.

In the period 1965 to 1976 inclusive, 55 patients suffering from duodenopancreatic adenocarcinoma were surgically treated at the Free University Hospital. Twenty of these patients underwent a 'curative' Whipple pancreaticoduodenectomy for a resectable tumor. The difference in survival time makes a differentiation important between carcinomas occurring in the head of the pancreas and those of the peri-ampullary region. In our series, 11 of the former were found and 9 of the latter group. Of each group one patient died within 30 days of the operation. The average survival time of 9 patients, operated on for a tumor in the head of the pancreas, was 10.2 months, with a range from 2 to 23 months. One patient is still alive 23 months after the operation. The average survival time of 5 patients with a periampullary tumor was 22 months with a range from 6 to 52 months. Three patients are still alive, one more than 12 years and 2 more than 19 months after operation. Considering the bad results, and the fact that 30 percent of pancreatic carcinomas are multifocal, it would seem that the classical Whipple operation is a thing of the past. One can then make a plea for total pancreaticoduodenectomy or even for a regional pancreatectomy. Thirty-five patients underwent a palliative procedure, consisting of a biliary bypass combined in a number of cases with a gastroenterostomy. Five patients died within 30 days of the operation. The average survival time for the remaining patients was 9.5 months with a range of 1.5 to 30 months.

Adenocarcinoma↗