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Biomedical subjects

G d'Ablaing

Publications and source records attributed to G d'Ablaing.

26 records · Page 2Linked to original sources
PubMed1988

Initial management of hydatidiform mole.

From July 1, 1969 to June 30, 1985, 381 patients received primary management for hydatidiform mole at Los Angeles County-University of Southern California Medical Center Women's Hospital. Three hundred fifty-eight of these women had complete records available for analysis. Of these, 277 women (77.4%) underwent suction curettage to remove the hydatidiform mole. Sharp curettage (41 patients, 11.5%), Pitocin (15, 4.2%), hysterectomy (12, 3.4%), prostaglandins (10, 2.8%), and hysterotomy (1, 0.3%) were used less frequently. Two patients (0.6%) had no therapy after spontaneous expulsion of a mole. Complications including infection, toxemia of pregnancy, anemia or hemorrhage, and postevacuation respiratory insufficiency were recorded in 242 patients (67.6%). This experience documents that hydatidiform mole is a high-risk pregnancy that requires prompt and intensive management. Suction curettage of the uterus is clearly the best means of management in most cases.

Abortion, Therapeutic↗
PubMed1987

The endocrinologic evaluation of a 45,X true hermaphrodite.

A 13-year-old 45,X girl presented with spontaneous menses and the acute onset of progressive hirsutism. Complete endocrinologic evaluation of hirsutism was unremarkable. An exploratory laparotomy revealed a gonad containing ovarian and testicular tissue. Chromosome analysis from four different tissues confirmed the karyotype to be 45,X. She was H-Y antigen positive.

Adolescent↗
PubMed1987

A critical evaluation of the endocervical curettage.

A prospective study was undertaken to critically evaluate the endocervical curettage. The study group consisted of 261 patients with colposcopically identifiable cervical lesions that had not been previously biopsied and were not macroscopically suspicious for invasive cancer. In 210 patients, the entire lesion, transformation zone, and squamocolumnar junction were visible (satisfactory colposcopy), and in 51 patients, the full extent of the lesion was not visualized colposcopically (unsatisfactory colposcopy). We used a method of examination not previously described. Colposcopy was performed before and after the endocervical curettage, but before the ectocervical biopsy. This method of examination allowed us to identify potentially contaminated endocervical curettages and to test the null hypothesis that a positive endocervical curettage in patients with satisfactory colposcopy is not the result of contamination. Twenty of 210 endocervical curettages in patients with satisfactory colposcopy were potentially contaminated, as suggested by an ectocervical lesion disrupted by the endocervical curettage. No patient with a positive endocervical curettage had an intact ectocervical lesion. Therefore, the null hypothesis was rejected (P less than .005). Of the 51 patients with unsatisfactory colposcopy, 39 (76%) underwent cone biopsy. Invasive cancer was diagnosed by cone biopsy in two patients when both ectocervical biopsy and endocervical curettage demonstrated only dysplasia. We also confirmed that patients with unsatisfactory colposcopy occasionally benefit from having an endocervical curettage. However, basing the treatment plan for any lesion short of invasive cancer solely on the results of colposcopy, ectocervical biopsy, and/or endocervical curettage could lead to significant undertreatment of some patients.

Biopsy↗
PubMed1986

Acute salpingitis subsequent to tubal ligation.

Acute salpingitis subsequent to tubal ligation is an uncommon event. Multiple studies have given credence to the assumption that salpingitis after tubal ligation does not occur. Four cases of salpingitis after tubal ligation are reported during the period of January 1980 to May 1985. This relates to an incidence of one in approximately 450 cases of acute salpingitis. A case of acute stump salpingitis with sequela from tubal rupture is reported and represents (to the authors' knowledge) the third reported case in the literature. Salpingitis can occur in the proximal stumps of tubes that have been ligated.

Acute Disease↗
PubMed1984

A clinical and pathologic study of 30 cases of malignant mixed mullerian epithelial and mesenchymal ovarian tumors: a Gynecologic Oncology Group study.

Between November 1971 and June 1980, thirty patients with primary malignant mixed mullerian tumors of the ovary were entered into a Gynecologic Oncology Group registry and treatment protocol. The mean age of the patients is 60.4 years. Six were Stage II, twenty-three were Stage III, and one patient had Stage IV disease. Among the 30 cases, 15 were designated carcinosarcomas (CS) and 15 were mixed mesodermal sarcomas (MMS). Twenty-three of the thirty study patients died from 1 to 16 months following their initial surgery. Two of the seven living patients have persistent cancer at 11 and 54 months. Four patients were alive and well at 6, 11, 22, and 32 months at the close of the study. Of the 12 patients receiving vincristine, dactinomycin, and cyclophosphamide (VAC) with (8 cases) or without (4 cases) radiation therapy (RT), there were two clinical complete responses; both died with disease at 6 and 16 months. One of the six patients receiving adriamycin had a complete response (CR). She is alive with disease at 11 months. There was no apparent difference in the survival or stage distribution among the cases with CS and MMS. Survival was somewhat better for the patients with earlier stage disease or smaller residual tumor burden.

Adenocarcinoma↗
PubMed1983

Broad ligament serous tumor of low malignant potential.

A papillary serous tumor of borderline malignancy (serous tumor of low malignant potential) was identified in the broad ligament of a 19-year-old woman. The tumor did not involve fallopian tube or ovary. Cysts and overt malignant tumors of the broad ligament have been previously reported; however, to our knowledge none have been identified as borderline malignant tumors. The müllerian origin of this tumor is discussed. Borderline lesions should be recognized because the prognosis differs from that of "true" carcinomas. Furthermore, borderline tumors must be separated from definite cancers if meaningful data about therapy are to be obtained.

Adnexal Diseases↗