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Biomedical subjects

G Zografi

Publications and source records attributed to G Zografi.

At least 73 records · Page 4Linked to original sources
PubMed1976

Wettability of pharmaceutical solids: estimates of solid surface polarity.

Contact angle measurements of water and methylene iodide with various organic solids were used to estimate the surface free energy per square centimeter, gammaS, and the contributions of nonpolar and polar forces, gammaSd and gammaSp, respectively. The ratio of gammaSp to gammaS was used as an estimate of solid surface polarity, and values ranging from 0 to 42% polarity were calculated for materials of pharmaceutical interest. Surface free energies per mole were calculated to compare the influence of different substituent groups on wettability. This approach offers a convenient means to quantitate the polarity of organic pharmaceutical solid surfaces.

Chemistry, Pharmaceutical↗
PubMed1975

Solubility of nonelectrolytes in polar solvents III: Alkyl p-aminobenzoates in polar and mixed solvents.

The relative solubilities of n-alkyl p-aminobenzoates in water, proplyene blycol-water mixtures, proplyene glycol, and several other pharmaceutically important solvents can be predicted on the basis of a theoretical equation. This equation relates the activity coefficient of the hydrophobic portion of the molecule to the product of its surface area and its interfacial tension [free energy per unit area of a hydrocarbon (tetradecane) against the polar or semipolar solvent of interest]. The assumptions, conclusions, and applicability of the theorectical relationship are compared to those of the Scatchard-Hildebrand approach.

Alcohols↗