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PubMed1998

Functional MRI statistical software packages: a comparative analysis.

Currently, there are many choices of software packages for the analysis of fMRI data, each offering many options. Since no one package can meet the needs of all fMRI laboratories, it is helpful to know what each package offers. Several software programs were evaluated for comparison of their documentation, ease of learning and use, referencing, data input steps required, types of statistical methods offered, and output choices. The functionality of each package was detailed and discussed. AFNI 2.01, SPM96, Stimulate 5.0, MEDIMAX 2.01, and FIT were tested. FIASCO, Yale, and MEDx 2.0 were described but not tested. A description of each package is provided.

Algorithms↗

PubMed1995

A comparison of approaches to the statistical analysis of [15O]H2O PET cognitive activation studies.

This study compares two of the most widely used statistical techniques for analyzing data obtained from [15O]H2O PET studies of brain function. The Friston method (SPM94) and the Worsley (Montreal) method were applied to a single data set of 33 subjects who were studied in a paradigm designed to evaluate memory for word lists. Neither of these methods emerged as either strikingly different or strikingly preferable, although the occasional differences may be important in some experiments. In general, the two methods were found to produce similar results in identifying brain regions active during long-term memory: frontal, parietal, cingulate, and cerebellar. Underlying assumptions of the two methods, as well as their strengths and weaknesses, are discussed.

Arousal↗