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Biomedical subjects

G Zanoni

Publications and source records attributed to G Zanoni.

33 records · Page 2Linked to original sources
PubMed1975

[Proceedings: The effect of volume manipulation (bloodletting or dextran administration) on pressure in the pulmonary circulation and on the hematocrit].

In a clinical survey the respective effects have been compared of venesection and of hypervolemic hemodilution on hematocrit and pressure in the pulmonary circulation. Whereas after venesection the pressure in the pulmonary circulation and the hematocrit decrease slightly, infusion of 1000 ml Macrodex is followed by marked hemodilution and a distinct increase in pressure in the pulmonary circulation.

Adult↗
PubMedDate not supplied

[Latent celiac disease in subjects with serum anti-endomysial antibodies and normal intestinal biopsy].

OBJECTIVES: Data on the follow-up of a group of subjects with serum antiendomysial antibodies (EMA) and normal mucosal architecture at the intestinal biopsy are reported. Clinical problems concerning possible evolution of potential celiac disease (CD) towards gluten-induced histological damage are discussed. METHODS: Eleven patients belonging to high-risk groups for CD (5 with type-1 diabetes, 2 with familiarity for CD and 4 with symptoms suggesting CD) who had a normal intestinal biopsy, despite positive antiendomysial test, were followed-up. Antigliadin and antitransglutaminase antibodies (anti-tTG) and HLA genotyping were also assessed. According to clinical and serological data a second biopsy was performed in six of them. RESULTS: At the time of the first normal biopsy, all patients were positive for EMA and 5/8 for anti-tTG. Five of 6 subjects genotyped were HLA-DQ2+ or DQ8+. Six patients were rebiopsed after 1 to 4 years. Three had mucosal atrophy, 1 had mild increase of intraepithelial lymphocytes and 2 were morphologically normal. CONCLUSIONS: Subjects with antiendomysial antibodies and normal intestinal biopsy deserve clinical and serological follow-up to reduce the time of possible latency of CD. Although good predictors of progression of the disease are not still available, antiendomysial antibodies assessment and HLA genotyping may help to suggest individuals at higher risk to develop gluten-induced enteropathy. This study confirms that subjects with persistent signs of gluten sensitivity and normal biopsy should be re-examined.

Adolescent↗