Search PubMed⌕ Search

Biomedical subjects

G Zanchin

Publications and source records attributed to G Zanchin.

59 records · Page 4Linked to original sources
PubMedDate not supplied

[Case of Horton's arteritis with development of simultaneous bilateral amaurosis].

The Authors report a case of temporal arteritis which started with a sudden onset of bilateral amaurosis. They considered this case worth recording, on account of its unusual and striking way of manifestation. Moreover, the importance of an early diagnosis of the disease is underlined, since an adequate steroid therapy, carried out in time, often allows to avoid the serious complications which may arise, particularly blindness. Recent epidemiological studies which showed the elevated incidence of the disease in patients above the age of 50, underline the necessity of considering temporal arteritis as one of the diagnostical possibilities, even if the symptomatology is defective or unclear.

Aged↗
PubMedDate not supplied

[Clinical and electromyographic observations on the diagnosis of motor neuron diseases (MND)].

A survey was made of 161 patients with a diagnosis of MND during the years 1965-1979 at the Neurological Clinic of Padova University. The results of a clinical and electromyographical reassessment is reported in 8 cases, selected out of the 24 surviving patients. Among this group, 3 patients had a moto-neuron disease, characterized by an exceptionally benign course, while in the remaining 5 the previous diagnosis was found to be inaccurate. The misleading clinical and EMG findings (at times encountered in the differential diagnosis of MND) are discussed: among them are previous illnesses such as poliomyelitis or radiculitis, inadequacy of both EMG techniques and the evaluation of fasciculations.

Aged↗
PubMedDate not supplied

[Aromatic and branched chain amino acids after porto-caval anastomosis: plasma and brain regional levels in the rat (author's transl)].

Automated analysis of aromatic and branched chain amino acids was performed in plasma and in four cerebral regions of rats submitted to chronic porto-caval shunt. Compared to controls, plasma of the operated animals exhibited a significant diminution of valine, leucine, isoleucine, a net increase of phenylalanine and tyrosine, with unchanged tryptophan levels. Brain valine, leucine and isoleucine were either increased or unchanged, whereas an enormous increase of aromatic amino acids, uniform in the four cerebral regions, was observed. The lack of correlation between plasmatic and cerebral levels of these essential amino acids leads to the hypothesis that cerebral permeability to amino acids is modified after experimental portocaval anatomosis: we recent confirmed that blood-brain mediated transport of the neutral amino acids is increased in this condition. A slower cerebral turnover of these metabolites could also contribute to elevate their cerebral concentrations after portocaval shunt.

Amino Acids↗
PubMedDate not supplied

[In vivo aminoacid transport in the brain of the rat with porto-caval anastomosis (author's transl)].

Cerebral capillary permeability to L-amino acids was studied in rats submitted to porto-caval anastomosis 4 weeks before. The short-term intracarotidal injection technique described by Oldendorf was used throughout. Neutral amino acid permeability appeared to be greatly increased, the most important enhancement being for the tryptophan. On the opposite, basic amino acids showed a net decrease in their rate of passage from blood to the brain. No changes were observed for GABA and glutamic acid. These data suggest a marked modification of the permeability of the cerebral capillary membranes in the rat with chronic portocaval anastomosis. Moreover, such alterations are selective for the different amino acid transport classes. Competitive inhibition decreased the permeability of methionine at the same level in both control and experimental animals: therefore, the neutral amino acid increased entry into the rat brain after porto-caval shunt is due to an enhancement of the transport processes.

Amino Acids↗