Biomedical subjects

G Yoshida

Publications and source records attributed to G Yoshida.

15 recordsLinked to original sources

PubMed1992

[Change in arterial ketone body ratio during gastrectomy and mastectomy].

We evaluated the influence of operative procedure on arterial ketone body ratio (AKBR), which indicates the function of the liver cells, in patients undergoing gastrectomy or mastectomy. AKBR during the stomach resection was significantly lower than that during the breast resection. A significant reduction in AKBR due to induced hypotension was observed in mastectomy group. SGOT and SGPT increased significantly in gastrectomy group, but unchanged in mastectomy group on the first and the seventh postoperative days. On the first post-operative day, SGOT and SGPT in gastrectomy group were significantly higher than those in mastectomy group. These findings suggest that influence of operative procedure on the liver during gastrectomy is more serious than that during mastectomy.

Adult↗

PubMed1992

[Effect of hypocapnia on arterial oxygenation during induced hypotension].

We evaluated the effects of hypocapnia on arterial oxygenation during induced hypotension with nitroglycerin (TNG) or prostaglandin E1 (PGE1) in patients undergoing mastectomy. Of the 20 patients studied, 10 belonged to TNG group and 10 belonged to PGE1 group. Mean arterial pressure during induced hypotension was maintained at 70% of the values observed before hypotension. A significant decrease in PaO2 was observed during hypotension under normocapnia (PaCO2 35-40 mmHg) in both groups. In addition, small but significant reduction in PaO2 from 128.5 +/- 23.7 mmHg to 122.5 +/- 25.5 mmHg in TNG group and from 129.9 +/- 11.9 mmHG to 116.7 +/- 15.6 mmHg in PGE1 group were induced by hypocapnia (PaCO2 27-30 mmHg) during hypotension. These findings suggest that usual dose of TNG and PGE1 might not or might partially inhibit hypoxic pulmonary vasoconstriction.

Adult↗

PubMed1992

[Effect of prostaglandin E1 on arterial ketone body ratio during gastrectomy].

We evaluated the effect of prostaglandin E1 (PGE1) on arterial ketone body ratio (AKBR), which is a parameter to indicate the function of the liver cells, in the patients undergoing total or subtotal gastrectomy. Twenty patients were divided into two groups: continuous intravenous administration of PGE1 (0.02 micrograms.kg-1.min-1) was started from 30 minutes after the beginning of the operation in 10 patients, and the remainders did not receive PGE1. AKBR levels at 30 minutes after the beginning of the operation (during the resection of stomach) were significantly lower than those after the resection of stomach in both groups. A significant increase in AKBR caused by the administration of PGE1 was observed during the resection of the stomach in PGE1 group. However, almost no change was observed in AKBR during the resection of the stomach in control group. These findings suggest that the administration of PGE1 has a protective effect on liver which is due mainly to the increase in hepatic blood flow during the resection of stomach.

Adult↗

PubMed1991

[Effect of clamping of portal vein on serum potassium level during hepatic resection].

We studied relation between the serum potassium changes and the factors affecting serum potassium level during hepatic resection in 23 patients. Serum potassium concentration became significantly higher after hepatic resection. The magnitude of increase in serum potassium concentration showed a correlation with total clamping time of the right or left portal vein (r = 0.576, P less than 0.01) and also with the amount of blood transfused (r = 0.441, P less than 0.05), but no significant correlation was found with fall in pH and urine output during hepatic resection. These results suggest that the duration of clamping of portal vein play the key role in the increment in serum potassium concentration during hepatic resection.

Carcinoma, Hepatocellular↗

PubMed1990

A case of facial diplegia associated with acute bilateral otitis media.

A 32-month-old toddler developed facial diplegia in association with a bout of acute bilateral otitis media. After 28 days of antibiotic therapy and placement of tympanostomy tubes, the patient demonstrated 100% symmetrical recovery. A brief discussion of the pathophysiology is included.

Acute Disease↗

PubMed1990

[Effect of induced hypotension on arterial blood ketone body ratio (AKBR)].

Arterial blood ketone body ratio (AKBR; acetoacetate/beta-hydroxybutyrate) is known as a parameter to indicate the function of the liver cells. We evaluated the effects of induced hypotension with prostaglandin E1 (PGE1) or trimetaphan (TMP) on AKBR in patients without liver disease undergoing mastectomy. Almost no change was observed in AKBR before, during and after hypotension with PGE1, but slight diminution was observed during hypotension with TMP. No hepatic dysfunction, however, developed in these patients postoperatively. These findings suggest that usual hypotension with TMP may provoke no postoperative hepatic dysfunction in patients without liver disease. For the patient who required either hypotension of long duration or hypotension with other factors affecting function of liver (surgical procedures, drugs and others), we prefer PGE1 to TMP as a hypotensive drug. We should also adopt PGE1 when cardiovascular control with hypotensive drug is necessary in patients with liver disease.

Alprostadil↗

PubMed1990

[Ventricular fibrillation after administration of aclacinomycin emulsion into mesenteric lymph nodes in a patient anesthetized with enflurane, nitrous oxide and oxygen].

A 57-year-old man was given 40 mg of activated carbon aclacinomycin (ACM) emulsion into mesenteric lymph nodes during anesthesia with enflurane, nitrous oxide, oxygen and epidural anesthesia. He had no complications preoperatively. Immediately after the injection, his skin turned to red, and 5 minutes later, sinus tachycardia, R wave amplitude reduction, T wave amplitude elevation, QT prolongation and PVCs were noted, and then, ventricular fibrillation (Vf) occurred 15 minutes after the injection. We succeeded in electrical defibrillation within about 180 seconds. At that time, both arterial blood gas and electrocytes were normal. Serum ACM concentration was remarkably elevated 60 minutes after the administration, and remained high 22 hrs later. Postoperative course was uneventful and he was discharged on the 17th postoperative day. It has been said that ACM has relatively low cardiotoxicity compared with adriamycin because of rapid distribution and metabolism. However, it might cause cardiac complication such as ECG abnormality, heart failure, pericarditis, though the effects are transient and reversible. Therefore we should be ready for its rapid treatment. Coenzyme Q10 could counteract cardiotoxicity of ACM.

Aclarubicin↗

PubMed1983

A chemical carcinogen, 3-methylcholanthrene, alters T-cell function and induces T-suppressor cells in a mouse model system.

The in-vivo effects of a polycyclic aromatic hydrocarbon (PAH), 3-methylcholanthrene (MCA), on in-vitro mitogen activation, cell-mediated lympholysis (CML) and T-cell subset distribution in mouse splenic lymphocyte populations were measured. Three inbred mouse strains were treated with a single intraperitoneal injection of corn oil alone or with different doses of MCA in oil (0.5-50 mg kg -1). One to ninety days after injection, splenic lymphocytes were isolated, and assayed for blastogenesis, CML and the percent T-helper and T-suppressor cells using monoclonal antibodies. High doses of MCA suppressed mitogen activation (15.2-53.6%) and CML (69-90%) within 24 hr in lymphocytes from PAH-responsive mice (C57 and C3H). Blastogenesis was stimulated and CML was suppressed to a lesser degree (5-45%) in lymphocytes from non-responsive mice (DBA). MCA induced an increase in T-suppressor cells in responsive mice, but there was no change in DBA mice. These studies suggest a correlation between immunocytotoxicity of PAH compounds on T-cell subsets and the responsiveness of mouse strains to these carcinogens.

Animals↗

PubMed1976

Measurement of intrahepatic shunted blood flow by ethanol-1-14C method as compared with D-galactose-1-14C method.

Ethanol-1-14C method for the measurement of intrahepatic shunted blood flow was compared with the method of continuous infusion of D-galactose-1-14C. In controls, in chronic hepatitis, and in hepatic cirrhosis, per cent intrahepatic shunt measured by the ethanol-1-14C- method was about a half or one-third of that measured by the D-galactose-1-14C method. Study of radioactivity-dye concentration ratio of the blood sampled from the inferior vena cava showed that per cent intrahepatic shunt was underestimated by the ethanol-1-14C method because of permeability of ethanol-1-14C through the capillaries. In patients with hepatic carcinoma, in whom the carcinomatous tissue was supplied mainly by the hepatic artery, there was no significant difference in per cent intrahepatic shunt between both methods.

Ethanol↗

PubMed1974