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Biomedical subjects

G Xu

Publications and source records attributed to G Xu.

At least 541 records · Page 30Linked to original sources
PubMed1990

[Investigation on resources of the Chinese drug beimu in Gansu Province].

Based on a resources investigation and taxonomic research on the medicinal plants of Fritillaria from Gansu Province. Nine species one variety and one cultivation variety have been reported. Records and distribution of the species, together with a key for the species and a key for the powdered drug have been furnished as well.

China↗
PubMed1990

[Various methods for purification of urine Tamm-Horsfall protein].

The measurements of serum, urine Tamm-Horsfall protein (THP) and its antibody are essential to the early diagnosis of tubulointerstitial diseases and acute rejection after renal transplantation. The purification of THP proves to be the key procedure for the production of diagnostic kit. Once, twice and three times salt precipitation with 0.58 mol/L NaCl and chromatography with Sephadax G-200 were adopted to purify urine THP. Enzyme immunoassay was used to detect the antigenicity of the products, SDS-PAGE to determine the molecular weight (MW) and the electrophoretic purity (EP), Beckman DU-7 model spectrophotometer to scan the ultraviolet absorption spectrum. Evaluation of the four methods was based on the purity and the antigenicity of the produced THP, the output, the complexity of procedure, and the cost of required materials. Results show that the MW of THP is 93.0 kd; the ultraviolet absorption maximum is at lambda = 278 nm; the outputs are 7.5, 5.5, 3.8, and 0.4 mg/L; the concentrations of THP with antigenicity are 65%, 75%, 98% and 100%, respectively, and the EPs of three times salt precipitation and chromatography are better. It is concluded that three times salt precipitation should be recommended because of its excellence in purity and antigenicity of the produced THP, the simplicity of manipulation, and the cheapness of the materials needed.

Humans↗
PubMed1990

Studies on antipeptic ulcer agents: a structure-activity relationship analysis of aldehyde semicarbazones and aryl hydrazones.

Twenty-eight condensation products of heterocyclic-a-carboaldehydes with N-aminooxazolidones, semicarbazides, thiosemicarbazides and benzoxycarbonyl hydrazide were synthesized so as to deduce the antiulcer pharmacophore or fragment of furazolidone (I), a prototype which has shown therapeutic efficacy in patients with gastric and duodenal ulcers. SAR analysis of the compounds indicated that the substitution of furan, thiophene, pyrrole or N-methyl pyrrole rings for 5-nitrofuran and the cleavage of the oxazolidone ring did not fully destroy the activity. The electron density of the carbonyl group was found to be of importance. A lead structure, therefore, was derived for further optimization.

Animals↗
PubMed1990

[The establishment of experiment model of gastric dysrhythmia and the study of its mechanism in rabbits].

In fasting and anaesthetic rabbits, the experimental model of gastric dysrhythmia could be produced by electric stimulation of inferior phrenicus vagus and splanchnic nerve for innervation of corpus and antrum, or by left gastric artery infusion of Adr, Ach and glucagon at a steady velocity. The results were as follows: (1) Electrical stimulation of inferior phrenicus vagus at low frequency and intensity could increase the frequency and amplitude of basic electric rhythmia (BER) or slow wave (P less than 0.01), and might induced tachygastria and tachyarrhythmia. Electrical stimulation of splanchnic nerve could increase the frequency and amplitude of BER (P less than 0.05), and might induced bradygastria. (2) Bradygastria could be elicited by left gastric artery infusion of Adr (400 micrograms/kg/h). The frequency and amplitude of BER induced were decreased. Tachyarrhythmia could be elicited by infusion of Ach (400 micrograms/kg/h). The frequency and amplitude of BER induced were increased. Dysrhythmia of BER could be elicited by infusion of glucagon (400 micrograms/kg/h). (3) Electroacupuncture of "Zusanli" acupoint may exhibit double modulated effects on experimental model of gastric dysrhythmia. Different types of gastric dysrhythmia including tachygastria, bradygastria and tachyarrhythmia could turned to approach the normal gastric myoelectric activity. It is revealed that such effects of electroacupuncture may be mediated via autonomic nerve and peripheric special receptors.

Acupuncture Therapy↗
PubMed1990

[An approach to mechanism of function of auricular point].

UNLABELLED: This investigation was performed with thirty adult rabbits which divided auricular vagus, great auricular, cervical sympathetic and all auricular denervation. By gastrointestinal electro-physiologic methods, the changes of gastrointestinal electric activity in corpus, antrum, duodenum and colon were observed with car needing to evaluate the mechanism of function of auricular point. RESULTS: In intact car innervation, the changes of gastrointestinal electric activity on ear needling were obvious (P less than 0.05-0.01). While the one with ear nerve selected showed that influence of ear acupuncture still remained, but when the whole auricle was denervated the influence of ear needling on gastrointestinal electric activity obviously deceased or disappeared. pro- and post needing the changes on gastrointestinal electric activity were not statistically different (P greater than 0.05). Recordings at the four parts of digestive tract gave similar results in frequency, amplitude, motility index, action area integral. Exerting stimulation on gastric vagus or sympathetic nerves could bring about double phase modulatory (excitatory or inhibitory). The above revealed that the functions of ear point in diagnosis and therapy is not due to one kind of nerves in periphery. The functions of ear point at innervation may be in its entirety. It was reported that function of ear points has something to do with auricular vagus or great auricular or sympathetic nerves, but, this is only one side of the matter. Moreover, since auricular point are associated with various propagation tracts and with modulation of nerve centers, their mechanism is very complicated and needs to be further studies.

Acupuncture Points↗
PubMed1990

[Studies on blood galactokinase of patients with presenile and senile cataracts].

Whole blood galactokinase (GK) activities were determined in 278 individuals including 77 patients with senile cataracts, 60 with presenile cataracts and 141 normal controls. No significant difference was found among the GK levels of the three groups. The frequency of GK heterozygocity in the presenile cataract group, however, was significantly higher than that in the normal control group (P less than 0.01), suggesting that even a partial decrease in GK activity might facilitate cataract formation in relatively early stages of life. The intake of milk and its products should be limited, both in GK homo- and heterozygotes.

Adolescent↗
PubMed1990

[Analysis of essential oils in roots and fruits of Angelica in Northeast China].

The essential oils of roots and fruits of five species of Angelica have been examined and analysed by GC-MS-DS; 59 chemical compounds are reported, of which alpha-pinene, myrcene and p-cymene are common to all five species. This paper provides a scientific basis for developing the resources of this genus in the Northeast.

Acyclic Monoterpenes↗
PubMed1990

[Survey of an outbreak of mycoplasmal pneumonia firstly discovered in Zhejiang Province].

An exceptional outbreak of mycoplasmal pneumonia in a factory of prisoners, Juzhou city, Zhejiang province, during November to December, 1985 was reported. In the course of the epidemic 102 cases were infected, with an attack rate of 3.3 per cent, but the attack rate in the outbreak point was 29.1 per cent. All cases were not dead. This outbreak was diagnosed as mycoplasmal pneumonia by clinical observation, X ray examination serological test and epidemiological survey. The sources of infection were 3 sporadic patients. The epidemic was quickly controlled by using comprehensive preventive measures.

Adolescent↗
PubMed1990

[Chemical constituents of Isodon parvifolia (Batalin) Hara].

Twelve compounds were isolated from the leaves and stems of Isodon parvifolia. This paper deals with the isolation and identification of two diterpenes epinodosinol (I), lasiodonin (II) and two triterpenes alpha-amyrin (XI a) and beta-amyrin (XI b).

Antineoplastic Agents, Phytogenic↗
PubMed1990

[Analgesic and sedative effects of the Chinese drug rhizoma Paridis].

The analgesic and sedative actions of Chinese drug Rhizoma Paridis are reported. All of the 6 experimented species and varieties in common use are obviously effective. Among them Paris polyphylla var. chinensis, P. polyphylla var. yunnanensis are stronger in analgesic action. Sedative action of P. fargesii, P. polyphylla var. chinensis, P. thibetica is also strong. In addition, pariphyllin A and gracillin were also used in the experiment.

Analgesics↗