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Biomedical subjects

G X Zhao

Publications and source records attributed to G X Zhao.

24 records · Page 2Linked to original sources
PubMed1991

Cytotoxic clerodane diterpenes from Polyalthia longifolia.

Bioassay-directed chemical investigation of the stem bark of Polyalthia longifolia Thw. (Annonaceae) has led to a novel clerodane diterpene, 16-oxo-cleroda-3, 13(14)Z-dien-15-oic acid, which was named polyalthialdoic acid (3). The bioassays also led to the previously known related diterpenes, kolavenic acid (2) which has not been reported as a constituent of this plant, and 16 alpha-hydroxy-cleroda-3,13(14)Z-dien-15,16-olide (1) which is previously known to be in this plant. These structures were identified by chemical and spectroscopic methods. All three compounds (1-3) were significantly bioactive in the brine shrimp bioassay; they strongly inhibited the growth of crown gall tumors on potato discs; and they were cytotoxic in three human tumor cell lines. These activities suggest potential antitumor applications. Compound 3 was the most active (ED50 values ca. 6 x 10(-1) micrograms/ml in the human tumor cell culture systems).

Antineoplastic Agents, Phytogenic↗
PubMed1991

Adrenal autotransplantation with A-V anastomosis for treatment of Cushing's disease. A follow-up study of 31 cases.

Thirty-one patients with Cushing's disease were treated with bilateral adrenalectomy and partial left adrenal autotransplantation with A-V anastomosis. They were followed up for 1 to 5 years. Three patients failed after adrenal autotransplantation to the abdominal muscle with the left gland's central vein anastomosed to the inferior epigastric artery. Twenty-eight patients underwent adrenal autotransplantation to the omentum with the gland's vein anastomosed to the gastroepiploic artery. Steroid could be omitted a short period after operation and life-long replacement therapy was avoidable in most patients. A few patients subsequently developed hypocorticalism. Two died and one had recurrence of Cushing's disease. Clinical and animal experimental results showed that the omentum is suitable for adrenal autotransplantation with A-V anastomosis. Transabdominal bilateral adrenalectomy and adrenal autotransplantation to the omentum with A-V anastomosis are acceptable in the treatment of Cushing's disease. The subsequent development of hypocorticalism and recurrence of Cushing's syndrome are also discussed.

Adolescent↗
PubMed1989

[Treatment of 94 cases of chronic empyema using a modified technique of decortication of the lung].

The article reported the use of a modified technique in the treatment of chronic empyema by decorticating only the visceral fibrous plate and leaving the parietal fibrous plate undecorticated. The cure rate was 100% and mortality rate 0%. This modified decortication has the advantages of simplifying the operative procedure shortening the operation time, lessening bleeding, and reducing operative trauma and risk. This modified technique may be applicable in most cases of chronic empyema.

Adolescent↗