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Biomedical subjects

G Wright

Publications and source records attributed to G Wright.

At least 253 records · Page 14Linked to original sources
PubMed1978

Cardiovascular effects of whole-body heating in spontaneously hypertensive rats.

The cardiovascular response to severe whole-body heating was examined in anesthetized spontaneously hypertensive (SH) (mean BP = 140 Torr) and normotensive (N) rats (mean BP = 96 Torr). Elevation of colonic temperature to 44 degrees C resulted in an initial increase in arterial pressure (mean BP: SH = 199 Torr, N = 124 Torr) with a subsequent severe hypotension. There was little evidence to suggest that this collapse in systemic pressure was related to a direct heat impairment of cardiac function. It was more likely the result of a progressive venodilation which produced venous pooling and decreased venous return. The arterial blood pressure response to exogenous catecholamine challenge decreased at elevated temperatures. This suggests that there was a deterioration of the vasoconstrictor response and indicated a possible effect of heat at the receptor or effector level. There were significant differences between the responses of normotensive and hypertensive rats to whole-body heating suggesting an enhanced cardiovascular sensitivity in hypertensive rats that may partially explain earlier reports of inferior thermoregulation and heat intolerance in these animals.

Animals↗
PubMed1977

Resistance to heat stress in the spontaneously hypertensive rat.

Thermal resistance as determined by survival time was examined in different age groups of spontaneously hypertensive (SHR) rats during terminal heating. A comparison with age or weight matched controls indicated that the thermal resistance of SHR animals was markedly inferior to that of normotensive animals as evidenced by 56% and 36% decreases in the total heating time to the lethal temperature, respectively. The decrease in thermal resistance in SHR animals occurred after 8 weeks of age and was coincident with the elevation of mean blood pressure to about 150 mmHg. The observation of significantly decreased total body water and rates of evaporation at critical colonic temperatures (39-40 degrees C) suggested the possibility of a reduced ability for water mobilization for thermoregulatory purposes in hypertensive animals although it appeared that other factors affecting heat gain or loss were involved.

Age Factors↗
PubMed1976

Some reactions to a dry-land training programme for dinghy sailors.

A dry-land winter training programme for dinghy-sailors is described. Individual elements include circuit training, specific exercises for muscle strength and endurance, and distance running. Ten international-class sailors followed a progressive regimen of this type for 14 weeks after completion of the 1973 season. Excess weight and skinfold thicknesses were reduced, while muscle strength, endurance and anaerobic capacity increased. Aerobic power remained substantially unchanged, although a smaller oxygen debt was incurred in reaching maximum effort. Team members were enthusiastic about the benefits gained from the training, commenting on their greater tolerance of the hiking position and all proposed to continue or to increase their efforts during subsequent winters. Racing results during 1974 were also an improvement on the 1973 record. However, it was difficult to link physiological gains to improvements in the relative rankings of individual competitors under either light or high wind conditions; the main factor changing relative standings seems to have been the additional year of competitive experiences in younger team members.

Body Weight↗
PubMed1976

Cellular aggregation and destruction during blood circulation and oxygenation.

Platelet and leucocyte aggregation and severe haemolysis may occur in blood during the preparation of an extracorporeal circuit for open-heart surgery. Experiments with dog blood showed that both processes result from bubble oxygenation but not from circulation of diluted blood and that they appear to be inhibited by the presence of acid citrate dextrose and heparin, or citrate phosphate dextrose and heparin, but not by heparin alone.

Animals↗
PubMed1975

Pathological effects of intra-arterial blood transfusions in dogs.

During storage, large cellular aggregates and clots formed in venous blood but not in arterial blood. Contrary to previous opinions, the intra-arterial transfusion of blood containing aggregates and clots did not cause focal brain damage and the presence of aggregates was not essential for the post-transfusion development of cerebral petechial and other minor haemorrhages.

Animals↗