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Biomedical subjects

G Wolff

Publications and source records attributed to G Wolff.

At least 127 records · Page 7Linked to original sources
PubMed1988

[Chronic gastritis and serum lipids, hypertension and cholelithiasis].

In 217 patients after gastric biopsies from corpus and antrum we looked for statistic correlations with lipids in serum, blood pressure, and gallstones. In patients with hypercholesterolemia we more often observed atrophic gastritis in antrum whereas in patients with hypertriglyceridemia or hypertension we more frequent found atrophic gastritis in corpus (significance on 5 per cent level). These results allow us to discuss the possibility, that arterial diseases may play a role in pathogenesis of atrophic gastritis. - In agreement with literature in cholelithiasis we found more often atrophic gastritis, but the difference was not statistically significant.

Adolescent↗
PubMed1987

[Dipyridamole and low-dose aspirin in patients with aortocoronary bypass--comparison with anticoagulation].

The effects of antiplatelet therapy (AP; dipyridamole 400 mg [beginning 2 days preoperatively] + aspirin 50 mg/day) and anticoagulation (AC) were compared prospectively in 251 patients with coronary artery bypass grafting (CABG). Two weeks postoperatively, 85.2% of AP and 81% of AC patients had all grafts patent with graft patency rates of 93.6% and 91.3% respectively (p = n.s.) Significant differences in favour of AP therapy were found in subgroups with multiple grafts and with low intraoperative graft flow. Up to 3 months postoperatively, severe complications occurred in 22 AC patients (11 bleedings) but only in 9 patients on AP therapy (p less than 0.01). Overall, AP therapy should therefore be preferred to AC in patients with CABG surgery.

Anticoagulants↗
PubMed1987

Comparison of the effects of inserted C40- and C50-terminally dihydroxylated carotenoids on the mechanical properties of various phospholipid vesicles.

We have measured the extent of incorporation of zeaxanthin (C40) and decaprenozeaxanthin (C50) in unilamellar vesicles of dimyristoylphosphatidylcholine (n-C14) and dipalmitoylphosphatidylcholine (n-C16). The incorporation is larger when the molecular length of the carotenoid corresponds to the thickness of the phospholipid bilayer. Stereochemically pure 2,3-di-O-phytanyl-sn-glycero-1-phosphocholine was prepared by modification of the polar heads of the phospholipids of Halobacterium halobium. Vesicles of this branched-chain ether phospholipid incorporate poorly the carotenoids, whereas egg lecithin vesicles incorporate them better. Osmotic swelling and water permeability of vesicles, with or without carotenoids, were measured in a stopped-flow, light-scattering system. The reinforcing effect (lower permeability and higher rigidity) of carotenoids at 1.5 mol% incorporation into diphytanylphosphatidylcholine vesicles is comparable to that of 5 mol% cholesterol; however, carotenoids have no measurable effect on the egg lecithin vesicles. These results imply that the reinforcement of the membrane depends on a subtle adjustment of the phospholipid-carotenoid system.

1,2-Dipalmitoylphosphatidylcholine↗
PubMed1987

Close linkage of the Wieacker-Wolff syndrome to the DNA segment DXYS1 in proximal Xq.

Linkage studies with RFLPs were performed in a large family in which the Wieacker-Wolff syndrome is segregating. In this new syndrome (McKusick, 1986, No. 31458) patients have congenital contractures, progressive neuropathic muscle atrophy, involving also some cranial nerves with oculomotor apraxia and dyspraxia of the face and tongue muscles, and mental retardation. This is an X-linked recessive syndrome. We found close linkage between the syndrome locus and the DNA segment DXYS1 (z = 3.225 at theta = 0.0) in proximal Xq.

Contracture↗
PubMed1987

[SPECT studies with 99mTc-HMPAO in Huntington's chorea patients].

Huntington's chorea is an autosomal dominant inherited disease with a chronic course and atrophy of the corpus striatum. PET examination shows reduced glucose metabolism in the caudate nucleus. We examined seven patients with Huntington's chorea by SPECT, using 99mTc-HMPAO. All patients had cortical defects of varying severity. In addition, five patients showed increased uptake in the region of the caudate nucleus. The specific tracer uptake due to the metabolic processes in the region of the caudate nucleus in Huntington's chorea is discussed.

Caudate Nucleus↗
PubMed1987

[Cerebro-costo-mandibular syndrome without cerebral involvement in a 4-year-old boy].

In a four year old boy the combination of Robin sequence and multiple dorsal rib defects on the first day of life could be classified as cerebro-costo-mandibular syndrome. In contrast to an unfavorable clinical course with cerebral involvement which has repeatedly been observed, in our patient psychomotor development has been normal so far. A brief literature review of a total of 36 patients shows that despite a unfavorable prognosis quoad vitam, roughly half the patients have survived. Half of the surviving patients showed functional disorders of the central nervous system, and only one third was mentally retarded. The favorable clinical course documented here thus supports the hypothesis that cerebral symptoms are not an obligatory component of the syndrome, but are only to be regarded as a facultative risk in the "costo-mandibular" syndrome. Accordingly, therapeutic nihilism does not seem to be justified. The etiology of the cerebro-costo-mandibular syndrome could not be clarified unequivocally up to now. A series of family observations indicate a monogenic cause, but genetic heterogeneity can not be ruled out.

Child, Preschool↗
PubMed1986

Familial pericentric inversion of chromosome 12.

A pericentric inversion in one of the chromosomes 12, found in two families living in the same region, is described. This inversion was detected during routine chromosomal analysis in two separate laboratories. The breakpoints were at 12p112 and 12q13. The inverted segment represented approximately 20% of the length of chromosome 12. Twenty nine descendants of carriers of the inversion were investigated, and the inversion was present in 23 of them. The other six descendants showed a normal karyotype. After correction for sample bias with the single selection scheme, a segregation ratio of 3:1 was estimated, indicating that the inverted chromosome 12 was preferentially transmitted. All the carriers of the inversion were phenotypically normal, without noticeable fertility disturbances.

Chromosome Banding↗
PubMed1986

Generation in vitro of alloreactive lymphocytes is suppressed by the addition of spleen cells from mice infected with lymphocytic choriomeningitis virus.

The generation of cytotoxic T cells to alloantigens in mixed lymphocyte culture was suppressed by the addition of spleen cells from adult mice acutely infected with lymphocytic choriomeningitis virus. T cells of surface phenotype Lyt 1+2+ were required for the suppression. Suppressive cells appeared also in lymph nodes, but not in the thymus. In the spleen their number was maximal 6 to 8 days after infection. Infectious virus could not be detected in the suppressive spleen cells. Therefore the virus itself does not seem to cause the effect.

Animals↗
PubMed1986

Gas exchange during mechanical ventilation and spontaneous breathing. Intermittent mandatory ventilation after open heart surgery.

Pulmonary gas exchange rates in eight patients after open heart surgery were studied during weaning from the ventilator. We investigated continuous positive pressure ventilation (CPPV), intermittent mandatory ventilation (IMV) and spontaneous breathing with continuous positive airway pressure (CPAP). During each mode of ventilation we measured: CO2 production (VCO2), O2 consumption (VO2), cardiac output (CO), PaO2, Qs/QT and functional residual capacity (FRC). In addition, we analyzed in each single breath: tidal volume (VT), series dead space volume (Vds), alveolar ventilation, alveolar efficiency for CO2 elimination (alv eff CO2) and end-tidal CO2 concentration (FCO2et). We compared the results of CPPV, IMV and CPAP and the mandatory breaths (MB) with the spontaneous breaths (SB) measured during IMV. CO was low during CPPV, when the patient still deeply sedated; it was increased in IMV and remained constant in the following CPAP period. VCO2 and VO2 did not differ significantly when switching from IMV to CPAP; therefore, work due to breathing seemed not to be reduced by the mandatory breath during IMV. Oxygenation (PaO2, Qs/QT) did not change significantly when switching from one mode to the other. FRC was constant when changing from CPPV to IMV, did not alter within the IMV-cycle and was reduced significantly when switching from IMV to CPAP. Dead space ventilation was reduced in SB (compared to MB). The latter result is discussed on the basis of two mechanisms: Vds was reduced and alv eff CO2 was increased. We conclude that compared to CPPV, IMV decreases mean alveolar pressure and reduces dead space ventilation at constant FRC and with constant oxygenation. This may explain why, in the weaning process, IMV makes it possible to start spontaneous breathing very early.

Adult↗