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Biomedical subjects

G Wolff

Publications and source records attributed to G Wolff.

At least 181 records · Page 10Linked to original sources
PubMed1981

Respiratory assistance on surgical wards with continuous positive airway pressure (Turbo-PEEP-Weaner).

Based on our own experience, we introduce a new continuous positive airway pressure device. The patient can breathe continuously positive airway pressure through a tight face mask, and thus the postoperative reduction in functional residual capacity is counteracted. This is shown by the well-documented clinical course of a 62 year old man who had respiratory insufficiency after proximal selective vagotomy.

Humans↗
PubMed1981

The effect of carbenoxolone on the chronic atrophic gastric mucosa determined by flow cytometry and histoautoradiography.

A trial with carbenoxolone at a dose of 150 mg/day for 6 months was performed in 24 patients with chronic atrophic gastritis. A control group of 21 patients received placebos. Gastric mucosa was examined by flow cytometry (FC) and histoautoradiography 2, 4, 12 and 24 weeks after starting therapy. Carbenoxolone had neither an effect on cell cycle stage distribution as determined by FC nor on the labelling indices obtained by histoautoradiography.

Adult↗
PubMed1981

[On acute gastritis (author's transl)].

In reviewing the literature we discussed the problem, whether there is a correspondence between the morphological picture of acute gastritis and the clinical expression including a complex of symptoms "acute gastritis", which should better be called acute dyspepsia. There is no good accord.--The histological main features of acute gastritis are infiltration of mucosa by neutrophils and the leucodiapedesis. this acute gastritis is very seldom the cause of clinical symptoms of acute dyspepsia. Alcohol, spices or drugs may produce a "toxic damage" of the mucosa, but they do not cause an acute gastritis, just as little as some viral diseases or staphylococcal toxins.

Acute Disease↗
PubMed1980

[Measurement and calculation of the colloid-osmotic pressure in the normal postoperative course].

In 26 patients undergoing elective surgery (general or urological) the colloid osmotic pressure (COP) of serum was followed up until the sixth postoperative day. COP was measured at an artificial membrane by a transducer as described by Weil et al. Simultaneous measurements of the concentrations of total protein and albumin were used to calculate COP by the formula of Keys. Measured COP and calculated COP were in close agreement; to eliminate the systematic (although small) difference, a correction of the Keys formula was developed. COP decreased postoperatively, but never below 20 mm Hg. While no circulatory or pulmonary dysfunction can be found, it seems superfluous to substitute COP if not below 20 mm Hg. The possible value of protein substitution is discussed.

Blood Proteins↗
PubMed1980

Familial congenital diaphragmatic defect: review and conclusions.

Seventeen reports dealing with familial congenital diaphragmatic defect are reviewed briefly. There are only weak hints of heterogeneity between sporadic and familial cases. It is concluded that multifactorial inheritance is the most likely explanation for the observed familial incidence of this malformation.

Female↗
PubMed1980

[Thoracic epidural analgesic (TEA) or controlled ventilation in the treatment of patients with multiple rib fractures (author's transl)].

In the last seven years 283 trauma patients were treated for multiple rib fractures and/or flail chest. Primary management consisted of only morphine analgesia in 16 patients, TEA in 112 patients, and mechanical ventilation in 155 patients. The indication for mechanical ventilation was always associated injuries (cerebral contusion, para- and tetraplegia, aspiration, severe lung contusion) and not the instability of the thoracic cage.

Anesthesia, Epidural↗
PubMed1980

[Antibiotic prophylaxis in colon surgery with Cefazolin].

In a prospective randomized and controlled double-blind trial the effect of prophylactic systemic administration of Cefazolin in elective colorectal surgery on postoperative wound infection was investigated. The incidence of wound infection was significantly reduced (P less than 0.01) from 32% in the control group to 10% in the treated group. Furthermore there was a significant reduction (P less than 0.05) in hospital stay of about 3 days.

Cefazolin↗
PubMed1980

[Congenital defects of the diaphragm in siblings. Two case reports (author's transl)].

In two different families each time two siblings head a congenital defect of the diaphragm, in 3 cases of the posterolateral type, in 1 case an almost complete aplasia of the diaphragm. Usually, the occurrence of defects of the diaphragm is sporadic. However, familial occurrence has been reported in 15 cases. Multifactorial inheritance is most likely the explanation for this. With this hypothesis a risk of 2% can be calculated for the recurrence of this malformation in a family with already one affected child.

Diaphragm↗
PubMed1979

[Respiratory insufficiency in surgery].

Acute respiratory insufficiency (ARI) (reduced PaO2 and/or increased PaCO2) in surgical patients is mostly caused by atelectasis or bronchopneumonia. These complications may develop if functional residual capacity (FRC) is reduced. Even in surgical patients with normal lungs the supine position, some pulmonary disorders after any general anaesthesia, pain, and atonic intestine cause reduced FRC in the postoperative phase. Successful prophylaxis is based on these mechanisms, which are described. The adult respiratory distress syndrome (ARDS, termed "shock lung" a few years ago) is the most dangerous pulmonary complication leading to ARI. The evaluation of clinical data sugggests that noxious factors only active for a short time (so called "triggers") may start the development of ARDS when some physiological conditions (so called "constellations"), such as low flow syndrome, reduced FRC and overhydration, pave the way for this. In the early state prognosis is good if the patient is ventilated (CPPV) and kept on the dry side, and if cardiac output is elevated compared to the normal value at rest. Once fully established, ARDS has such a poor prognosis that the need for earliest possible commencement of therapy must be stressed emphatically. The following values may be taken as clear and simple symptoms for early diagnosis: vital capacity below 15 ml/kg (reflects decreased FRC), PaO2 breathing spontaneously room air below 60 mm Hg or 8 kPa (reflects increased intrapulmonary right to left shunt or regional hypoventilation), and respiratory rate above 25/min (reflects loss of compliance).

Adult↗
PubMed1979

[The respiratory intensive unit. Requirements for the treatment of patients with acute respiratory insufficiency].

Patients with acute severe respiratory insufficiency can only be correctly monitored, treated and nursed in a well-equipped intensive care unit staffed with well-trained personnel. Qualified doctors and nursing staff are more important for the monitoring and assessment of the patient's symptoms than highly sophisticated electronic monitoring systems. Continuous controls of vital and mechanical functions are however essential , as are the services of well-run laboratories. Treatment calls, above all, for the use of efficient and reliable respirators capable of adjustment to suit the impaired breathing. The quality of nursing and the success of intensive medical care measures are best ensured by well-designed layouts, strict adherence to sensible and appropriate hygienic techniques, continuous and practice-related further education for personnel, and unrestricted communication inside and outside the intensive care unit.

Humans↗