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Biomedical subjects

G Wittrin

Publications and source records attributed to G Wittrin.

17 recordsLinked to original sources
PubMed1979

[Acute pancreatitis in animal experiments - a new method].

Acute pancreatitis was induced in 30 minipigs (Göttingen) by implantation of a T-drain into the Ductus Wirsungianus. The distal part of the T-drain, which led into the duodenum was stenosed to 1/3 of the original diameter. The inflammation was caused by stenosis of the Ductus Wirsungianus additionally by application of contrast medium. The course of the inflammation was demonstrated by biochemical, roentgenological and histological examinations.

Acute Disease↗
PubMed1979

[Echinococcus cysticus (author's transl)].

Echinococcus cysticus is a parasite; the human organism is invaded by cysticercus of the dog tape worm. In liver 60% of all viable embryos are retained, 30% in the lung, the last 10% spread via the arterial system into all other organs. Diagnosis can be established by serology, sonography, scintigraphy as well as invasive and non-invasive radiological examinations. Case reports of 20 patients with Echinococcus cysticus are given; the disease was localized 16 times in the liver, 3 times in the lung and once in the spleen. Drugs or x-ray treatment have no sufficient therapeutical effect. Trivial trauma can cause rupture of the cysts; therefore surgery is indicated.

Adult↗
PubMed1978

[Treatment of malignant lesions of the esophagus with the thermoprobe].

In inoperable stenosing tumours of the oesophagus the problem arises of maintaining oral food intake. As malignant cells are more cold-sensitive than normal cells oesophageal tumours may be "cold-coagulated" with special probes. Preliminary results with this treatment in 28 patients are reported.

Esophageal Neoplasms↗
PubMed1978

[Replacement of the common bile duct by an autologous vein (author's transl)].

3 cm of the common bile duct was removed in 19 dogs and the defect was bridged by an autologous vein. The interposition of a vein graft was performed with a double end-to-end anastomosis. In four cases a T-drain was additionally placed into the transplant. GOT, GPT, LDH, AP and bilirubin were tested in regular intervals. The patency of the transplant was proved by radiography with dogs which survived longer than 6 weeks. 5 dogs died within the first 4 weeks, 4 were killed after 2 months, because of incrustation of the T-drain for a regular percutaneous rinsing of the drainage was not possible. 10 dogs survived for 6 to 12 months. These animals showed increasing laboratory results up to two months, then the tests normalized. The function of the transplanted vein was without complication and the liver histology did not show any pathological alteration. After two months the transplanted vein was bridged by bile duct epithelium.

Alanine Transaminase↗
PubMed1978

Endoscopic retrograde cholangiography (ERC) in surgical emergencies.

Twelve patients, presenting with an acute abdomen of suspected biliary tract origin, had endoscopic retrograde cholangiography performed. Eight patients had either traumatic, spontaneous, or postoperative biliary tract fistulas with five leading to the peritoneal cavity, one to the colon, one to the bronchial tree, and one to the liver parenchyma from a ruptured gall-bladder. Each was confirmed by endoscopic retrograde cholangiography. Four patients with jaundice, following traumatic rupture of the liver, had a pathological communication between the intrahepatic biliary tracts and the hepatic vascular system. It is concluded that ERC is a reliable method for obtaining precise localization of biliary tract problems in surgical emergencies both pre- and post-operatively.

Adolescent↗
PubMed1978

[Surgery of chronic intestinal ischemia (author's transl)].

Chronic intestinal ischemia has to be diagnosed by an interdisciplinary approach. Clinical symptoms are unrevealing; usually the internist and the radiologist make the diagnosis after numerous special examinations and arteriography of the abdominal aorta in two planes. Indications for conservative treatment vs. surgery have to be discussed between the specialists involved, that is the internist, the radiologist, the anesthesist and the surgeon. Surgical problems in cases with chronic vascular occlusions are problems of vascular surgery and surgery may be well planned and performed electively. Acute occlusions of intestinal vessels however require mostly immediate surgery of the intestine itself which has to be performed as an emergency procedure because of the impending organ necrosis and complications; this is demonstrated in the case of ischemic colitis.

Aorta, Abdominal↗
PubMed1978

[Hemobilia and bilhemia complicating liver trauma (author's transl)].

Hemobilia and bilhemia are typical complications of liver trauma which have been found more often during the last years. Today gastroduodenoscopy, retrograde cholangiography, selective angiography and scintillation scanning of the liver make an exact diagnosis possible. In the case of hemobilia a ligature of the corresponding artery might be successful, whereas in the case of bilhemia only partial resection of the liver leads to success.

Adolescent↗
PubMed1978

[Bileduct reoperations (author's transl)].

After cholecystectomy reoperations are required in 7%. A reoperation in indicated by pathologic alterations overlooked at the first operation, not working biliodigestive anastomoses and injuries to the common bile duct. 138 reoperations of the bile duct wer performed within 4 years which were aimed at reconstructing the normal bile duct anatomy. Mortality rate 8,7%.

Ampulla of Vater↗
PubMed1977

[Bronchobiliary fistula. Pathogenesis, diagnosis, therapy].

The case demonstrated shows the pathomechanism of bronchobiliary fistula. In most cases, bronchobiliary fistulae are caused by stenosing lesions of the common bile duct. For diagnosis the combined cholangio-bronchography is the preferred method. Removal of the obstructing lesion is the aim of operative treatment. Usually spontaneous healing of the bronchobiliary fistula results.

Adult↗
PubMed1975

[The determination of catalase activity in liver tissue (author's transl)].

In 31 patients with carcinoma and 45 controls catalase activity of liver tissue was measured spectrophotometrically. In patients with carcinoma the activity was significantly lower. Within the control group patients with pathological liver findings or inflammatory disease of the pancreas or bile ducts showed a relatively low catalase activity which are obviously higher than in patients with carcinoma.

Biliary Tract Diseases↗
PubMed1975

[Diagnosis and surgical treatment of bronchial carcinoma - a report on 1000 cases (author's transl)].

One thousand cases of bronchial carcinoma, which had been treated in the Chirurgische Universitätsklinik Erlangen in 17 years, are reported. 63,2% were either primarily inoperable or found to be so after an exploratory laparotomy; Only 32,4% of all patients were admitted in the first 3 months, 17,6% after more than 12 months, Squamous epithelial carcinoma was the most frequent histological type (51,2%), then came small cell carcinoma (16,4%), dedifferentiated carcinoma (5,1%) and adenocarcinoma (4,1%). The best results of operative treatment were obtained with lobectomy in Stage I with a five year survival rate of 45%. In Stage II, pneumonectomy is the satisfactory operation (no five year cure with lobectomy, but 25,2% with pneumonectomy). Exploratory thoracotomy does not shorten the life expectancy and it should therefore be performed in doubtful cases.

Adenocarcinoma↗
PubMed1975

[Hemobilia (author's transl)].

Hemobilia is a syndrome caused by hemorrhage into the biliary ducts. It is characterized by colicky pains, jaundice, and intestinal bleeding; a correct diagnosis of this syndrome is made rather rarely. The most common cause is trauma; inflammatory or tumorous disease of the liver and bile duct system, bile stones and aneurysms of the hepatic artery are rarer causes. The diagnosis can be established and the arterio-biliary fistula localized by selective arteriography. A case is described, which shows, that, in addition, duodenoscopy with retrograde cholangiography is of diagnostic value. Other helpful diagnostic procedures are: splenoportography, liver scanning, and intraoperative cholangiography. Therapy must be surgical exclusively; palliative operations lead to high rates of relapses and letality. Best results are achieved by ligature of the hepatic artery in cases of central, or by partial resection of the liver in cases of peripheral localization of the fistula.

Accidents, Traffic↗
PubMed1975

[Hemobilia following liver injury].

A case of post-traumatic haemobilia is presented and the diagnostic and therapeutic aspects of this condition are discussed. In addition to coeliacography, spleno-portography and scan, retrograde endoscopic cholangiography is a valuable diagnostic technique. Treatment is operatively, by drainage and haemostasis of the affected area with liver resection or by ligation of the afferent arteries. In the case presented ligation of the left hepatic artery was successful.

Adolescent↗