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Biomedical subjects

G Winkler

Publications and source records attributed to G Winkler.

At least 127 records · Page 7Linked to original sources
PubMed1985

[Diabetes mellitus type I, thyroid gland autoimmunity, thyroid gland function and HLA status].

In a cross-sectional study sera of 130 children and adolescents with insulin dependent (type I) diabetes were tested for the presence of cytoplasmatic islet cell antibodies (ICA), thyroid microsomal antibodies (TMA) as well as thyroid function (T3, T4, thyrotrophin). 102 of the patients were examined for thyroid enlargement, all patients with TMA were within this group. TMA were found in 15.4%, ICA in 38.5%, the latter decreasing with duration of diabetes. Of the TMA positive sera, 45% were also ICA positive, but only one child out of these was diabetic for more than 5 years. Thyroid enlargement occurred in 33.3%, however in TMA positive patients in 70%, of which one girl suffered from hypothyroidism due to biopsy-proven Hashimoto's thyroiditis, all the other diabetics being euthyroid. There was no sex predisposition. By HLA-typing 40% of TMA positive patients expressed the HLA-DR3 antigen which is said to be responsible for "autoimmune" diabetes, whereas only some of these were ICA positive as well. In our study, no significant association was found between presence or even persistence of ICA and TMA, nor between thyroid autoimmunity and HLA-DR3. Since type I diabetic patients with thyroid autoimmunity are predisposed to develop hypothyroidism with time, less likely also Addison's disease, screening of type I diabetics for thyroid microsomal antibodies should be considered especially in those with thyroid enlargement.

Adolescent↗
PubMed1979

[The effect of weather on blood sugar fluctuations in insulin-dependent patients. Medical meteorological observations (author's transl)].

In agreement with the results of urinary sugar examinations obtained by other authors it was established that there are probable connections between biochemical parameters and climatic events and that the reaction of the blood sugar to meterological changes may be an index for the changing responses of the body to weather as a stress factor. Further investigations, especially on the temporal distribution of hypoglycemias should contribute to a clearer explanation of the undoubtedly important correlation which could be shown to be helpful in the optimal stabilization of diabetics.

Adolescent↗
PubMed1978

C-peptide secretion during the remission phase of juvenile diabetes.

C-peptide secretion was studied in eight juvenile diabetics during the remission phase of the disease. The release of C-peptide was measured after a (1) normal intravenous glucose tolerance test, (2) a double glucose tolerance test, (3) an arginine infusion, and (4) after an intravenous glucose tolerance test followed by an arginine infusion. Under all conditions the intravenous glucose load had only a minimal effect on the secretion of C-peptide, while arginine alone or after the intravenous glucose tolerance test stimulated the release of the peptide in all patients. Pretreatment with glucose did not augment the effect of arginine on C-peptide release. The results indicate that during the remission phase of juvenile-onset diabetes the endocrine pancreas does not recognize glucose as and appropriate signal for C-peptide release and cannot transform the amplifying effect of glucose into a higher hormonal secretion rate.

Adolescent↗
PubMed1977

[Primary carcinoma of the liver and long-term administration of oral contraceptives followed by pregnancy (author's transl)].

A 32-year-old woman who had taken oral contraceptives for seven years, became pregnant after omitting the drug and had a normal child. Soon after a malignant hepatic tumour became apparent of which she died after three months. The tumour was a hepatocellular carcinoma, of low differentiation under the electron microscope. The tumour cells contained fibrils similar to alcoholic hyaline. A review of published reports suggests the possibility that the oral contraceptives and the hormonal influence of the pregnancy together played an important role in the development of the malignant tumour.

Adult↗
PubMed1976

[Effect of noise on the physiological functions in fowl. 3. Effects of primary and repetitive acoustic stimulation on glucose and free-fatty-acid plasma levels in broilers of different age groups].

The effects of first and repetitive noise applications to broilers, aged 14, 28, and 56 days, were tested by the responses of the energetic substrates plasma glucose concentration and free fatty acids. The plasma concentrations of glucose and free fatty acids in broilers at slaughter age with no exposure to noise were higher than those in younger animals. Regular daily noise application of 100 dB, 60 to 8,000 Hz, for 30 minutes, which began on the first day of age, led to rises in the plasma glucose levels of animals aged 56 and 28 days even prior to renewed acoustic stimulation, which obviously was a conditioned reflex. Such rises were accompanied by decline in plasma concentrations of free fatty acids, which phenomenon was attributed to higher initial values of plasma glucose. First as well as repetitive noise application led to changes in the plasma content of energetic substrates. Both the direction and magnitude of the reaction appeared to depend on the given initial value. The plasma level responses of glucose and free fatty acids were opposite to one another in all animals, 56 days of age, which were exposed to repeated noise.

Acoustic Stimulation↗
PubMed1975

Antidiabetic action of somatostatin--assessed by the artificial pancreas.

By means of a glucose-controlled insulin- and glucose-infusion system (GCIGIS) we examined the effect of somatostatin on insulin and glucose requirements following meals or oral glucose loads in juvenile diabetics. In six of seven patients the insulin requirement with somatostatin was remarkably reduced to between 38 per cent and 79 per cent of that of otherwise identical control experiments. No reduction could be found in the seventh case, fed only 575 kcal. In all cases we observed an increase in dextrose demanded from the GCIGIS ranging between 28 per cent and 192 per cent of the control amounts. In addition, a lowering and smoothing of postprandial blood glucose curves caused by somatostatin application was a general finding. It seems to us most likely that the well-known suppression of the secretion of growth hormone and glucagon, both insulin antagonists, is responsible for the antidiabetic action of somatostatin.

Adolescent↗