Search PubMed⌕ Search

Biomedical subjects

G Wimmer

Publications and source records attributed to G Wimmer.

18 recordsLinked to original sources
PubMed2003

Severe heart failure from light chain cardiomyopathy (cardiac amyloidosis).

Primary (AL)amyloidosis is characterized by clonal production of immunoglobulin with subsequent deposition in several organs. We describe the clinical features of a 66-year old female who was referred to our department for congestive heart failure. One year before, she was examined and found to have diastolic dysfunction of the left ventricle. We could evaluate the diagnosis of primary amyloid cardiomyopathy by echocardiography, Doppler echocardiography and laboratory findings and confirmed the diagnosis by biopsy of the rectum mucosa. Clinical outcome was poor, because therapy is poor.

Aged↗
PubMed2003

The effect of three different periodontal pre-treatment procedures on the success of telescopic removable partial dentures.

In this prospective study, 120 teeth consisting of maxillary and mandibular canines and premolars were divided into three groups each containing 40 teeth. The teeth were assigned randomly in quadrants to three different periodontal treatment protocols. The first group was treated with professional prophylaxis only. The second group received additional deep scaling. With the third group, additional surgical periodontal flap surgery and scaling was performed. Both papillary bleeding index (PBI) and probing depth (PD) were evaluated before, during and after treatment. During the subsequent prosthetic treatment phase all teeth were then used as telescope abutments supporting a removable prosthesis. The documentation of the attachment level (AL) was then used as a clinical parameter. One year after the incorporation of telescopic removable partial dentures (RPDs), PD, PBI and AL were again evaluated. The resulting periodontal parameters were compared between the different groups using the general linear model (GLM) repeated measures and the Kruskal-Wallis test for non-parametric variables. Differences within the three treatment groups were determined using the t-test, e.g. the Wilcoxon test for dependent variables (P < 0.05). A significant decrease in inflammatory indices (PBI) was found for all types of periodontal treatment (P < 0.03 for all groups). Additionally, the reduction in PD was significant for all of the three groups (P < 0.001 for all groups). The greatest reduction in PD was observed in the group in which a surgical approach was used. Evaluation of the attachment level after the incorporation of the telescopic RPDs showed that tooth position did not influence the periodontal prognosis and that the use of telescopic RPDs exerted no ascertainable negative influence on the periodontium of the abutment teeth.

Adult↗
PubMed2003

Functional quality of molar crown occlusal surfaces in the different design modes of Cerec 2.

The goal of the present study was to objectify whether the design modes of "Correlation", "Function", and "Extrapolation" of the Cerec 2 system are suitable for generating a functionally perfect occlusal surface of a first mandibular molar crown. For this purpose, an occlusal surface was waxed up according to the biomechanical concept of MH Polz, and this served as the reference occlusal surface. Four different Cerec 2 comparison crowns (produced in the laboratory, Extrapolation mode, Correlation mode, Function mode) were produced and the positions of the cusps were measured. It was shown that the Correlation mode delivers the most accurate results, and the manually produced occlusal surface also showed good results. The occlusal surfaces of the crowns produced according to the Extrapolation and Function mode were clearly inferior.

Ceramics↗
PubMed2001

Apolipoprotein E epsilon 4 is associated with rapid progression of multiple sclerosis.

OBJECTIVE: The apolipoprotein E (APOE) polymorphism is known to impact on various neurologic disorders and has differential effects on the immune system and on CNS repair. Previous findings concerning a possible modulation of the clinical course of MS have been inconsistent, however. METHODS: In a cross-sectional study, the authors investigated 374 patients with clinically definite MS and a disease duration of at least 3 years and related their clinical and demographic findings to the allelic polymorphism of the APOE gene. The genotype distribution of patients with MS was compared with a cohort of 389 asymptomatic, randomly selected elderly volunteers. RESULTS: The authors found no significant differences in the distribution of genotypes between patients with MS and controls. However, patients with MS with the epsilon4 allele (n = 85) had a significantly higher progression index of disability (0.46 +/- 0.4 versus 0.33 +/- 0.26; p < 0.004) and a worse ranked MS severity score (5.1 +/- 1.9 versus 5.7 +/- 1.7; p = 0.05) than their non-epsilon4 counterparts, despite significantly more frequent long-term immunotherapy in epsilon4 carriers (74% versus 58%; p < 0.007). The annual relapse rate in epsilon4 carriers (0.87 +/- 0.56) was significantly higher than in patients with MS without an epsilon4 allele (0.71 +/- 0.47; p = 0.03). CONCLUSIONS: These results suggest no effect of the APOE genotype on susceptibility to MS, but indicate an association of the APOE epsilon4 allele with a more severe course of the disease.

Adult↗
PubMed2000

[Clinical value of FDG PET using coincident gamma cameras in staging and restaging of malignant lymphoma--compared with convenitonal diagnostic methods].

UNLABELLED: AIM of the present retrospective study was to validate the clinical value of F-18-FDG PET imaging in lymphoma patients with a dual head camera modified for coincidence detection. Staging before and after oncological treatment was compared with a conservative diagnostic approach. METHODS: 48 patients (28 non-Hodgkin lymphoma, 20 Hodgkin's disease) received FDG-Hybrid-PET scans. Pretherapeutic staging was realized in 28 patients, 9 of them had control studies after they had completed therapy. Totally 29 persons were examined for post-therapeutic restaging. Computed tomography imaging and lymph node sonography was performed in all cases. Results were validated by clinical follow-up, in three cases a recidive was proven by biopsy. RESULTS: CT and ultrasound detected 77 lesions in 28 patients compared with 100 visualized by PET, but this difference in pretherapeutic staging did not reach significance at p > 0.05 by Fisher's t-test. Hybrid-PET obtained a sensitivity of 93%, a specificity of 79%, a positive of 82% and a negative predictive value of 92% for detection of residual disease. The values for CT + US were 87%, 64%, 72% and 88% respectively. CONCLUSION: FDG Hybrid-PET is as or even more accurate than standard morphologic diagnostic methods for prestaging in malignant lymphoma. Additionally, there is a substantial benefit for therapy monitoring of residual disease using coincidence detection PET with a 3/4-inch crystal gamma camera.

Adult↗
PubMed2000

Residual dentin thickness after 1.2-mm shoulder preparation for Cerec crowns.

Since the introduction of crown software for Cerec, it has been possible to produce full-ceramic crown restorations. Despite the excellent material quality of industrially made ceramic blocks and the good clinical long-term success of these ceramics in inlay- and onlay preparations, extended preparation with high loss of dental tissue is incident to crown restorations, which may endanger the vitality of the respective tooth. The aim of this experimental study was to determine the residual dentin thickness after preparation of an extended circular shoulder in the molar and premolar region. On extracted human molars and premolars, 1.2-mm-wide circular shoulders with rounded inner edges were prepared, and the thickness of the residual dentin wall was measured under a microscope. Using this preparation method, it was found that only the group of maxillary molars showed an average residual dentin thickness of more than 0.7 mm.

Bicuspid↗
PubMed1999

[Primary lymphoma of the thyroid with contralateral recurrence--case report].

Primary lymphomas located in the thyroid gland are rare clinical findings. The therapy and the subsequent monitoring of the disease continue to be a subject of debate. We present the case of a 63-year-old female patient in whom a hemi-thyroidectomy was performed because of a growing goiter. Histological examination of the excised tissue revealed a large-cell B-lymphocytic lymphoma which extended to neighboring lymph nodes. The patient received chemotherapy which led to remission of disease for two years. The disease re-occurred in the remaining thyroid lobe. Subsequently, the patient was treated with involved-field radiation therapy which lead to long term remission. We conclude that total thyroidectomy should be considered in the treatment of lymphomas located in the thyroid gland.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1990

[The startle response and epilepsy].

Startle responses (SR) are described as epileptic and non-epileptic attacks and their mechanisms are poorly understood. Long-loop reflexes and a satisfactory response to L-tryptophan treatment have only seldom been published in this condition. This prompted us to report a case with epilepsy and startle-induced tonic spasms, the latter refractory to all conventional medication except for L-tryptophan. Special emphasis is placed on the electrophysiological findings. Similar observations of non-habituation of SR in post-anoxic brain damage and in the case of startle epilepsy possibly suggest a deficit of cortical inhibition, probably in the supplementary motor area, rather than brain stem dysfunction in both instances.

Adult↗
PubMed1985

[Demonstration of aortocoronary venous bypasses using digital subtraction angiography].

In 43 patients with a total of 86 aortocoronary bypass grafts digital subtraction angiography was employed in the early post-operative period. Contrast injection into the aortic root allowed in all instances a definitive answer whether the aortocoronary bypass was free or obstructed. The method makes it possible also to assess distal anastomoses and their connected coronary vascular bed.

Adult↗
PubMed1983

[Procedure for shunt imaging in dialysis patients with special reference to digital subtraction angiography].

All angiographic procedures established for imaging of hemodialysis fistulas, such as direct venous angiography, intravenous subtraction angiography and arteriography by direct puncture of the brachial artery or by Seldinger's transfemoral technique, can also be effected with digital image processing. Depending on the angiographic technique, the use of digital subtraction angiography has several advantages: lower doses and concentrations of the contrast agent, lower risk of complications (thrombosis of the fistula, vasospasm) and freedom from pain. In addition, there is a marked reduction of examination time and film cost.

Angiography↗
PubMedDate not supplied

Myofibrillar (desmin-related) myopathy: clinico-pathological spectrum in 3 cases and review of the literature.

Myofibrillar or desmin-related myopathies encompass neuromuscular disorders with abnormal deposits of desmin and myofibrillar alterations. We report 3 unrelated patients presenting with proximal and distal myopathy, and, as a unique congenital syndrome, diffusely distributed myopathy, osteoporosis and myopia. Muscle biopsies shared cytoplasmic inclusions, rimmed vacuoles, and ragged-red-like fibers. Sarcoplasmic inclusions, either plaque-like or amorphous, strongly immunoreacted on dystrophin and variably for desmin, alphaB crystallin and ubiquitin. Cyclin-dependent kinases CDK1, CDK2 and CDK5 were overexpressed in affected fibers. Ultrastructurally, focal myofibrillar disruption was accompanied by tubulo-filamentous inclusions in one case and abundant glycogen and enlarged mitochondria displaying respiratory chain dysfunction at biochemistry in another case. Molecular analysis of the alphaB crystallin gene coding sequence and exons 4, 5 and 6 of the desmin gene did not reveal any mutation. The morphologic denominator of hyaline structures and areas of myofibrillar destruction occurs in heterogeneous conditions and may overlap with features of inclusion body myopathy and mitochondrial myopathy.

Adult↗
PubMedDate not supplied

Prevalence of varicose veins of the lower limbs in the women working at a department store.

The prevalence of varicose veins of the lower limbs and their risk factors were investigated in the group of 696 women working at a large department store. It was found that 421 of them suffered from varicose veins with the following prevalence of individual clinical types: trunk varices--14.4%, reticular varices--15.4%, and hyphenwebs--30.7%. In our study women with VV of all types compared to women without VV were older (p less than 0.05), more often obese (p less than 0.05), had the positive family history for VV (p less than 0.01), higher systolic and diastolic blood pressure and lower levels of physical activity (not significantly). Women with at least one pregnancy had significantly higher prevalence of VV (p less than 0.001) and women standing at their work had a higher prevalence of trunk varices than those who were sitting at the work (p less than 0.05).

Adult↗