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Biomedical subjects

G Wilson

Publications and source records attributed to G Wilson.

At least 397 records · Page 22Linked to original sources
PubMed1967

Aortography in the diagnosis of cancer.

The role of angiography in the diagnosis of cancer includes the direct visualization of the tumor, the demonstration of its size, extent and possible metastasis. The criteria which are used to judge the prognosis of a tumor include the size, angiographic appearance, relationship to adjacent organs and tissues, growth or extension into draining veins and the presence or absence of metastasis. Chemotherapeutic agents can be instilled through the same catheters that are used for angiography and these catheters may be left in place from five to eight days.

Adult↗
PubMedDate not supplied

Cell culture techniques for the study of drug transport.

The growth of differentiated cell monolayers on microporous filters is providing powerful new techniques for investigating the transport of drug and delivery systems across defined cellular barriers, and for discriminating between different routes and mechanisms. The growth, characterization and potential use of these systems is illustrated by studies on the human Caco-2 cell system which provides an in vitro model of the intestinal epithelial barrier. This system, still in the early stages of characterization and development, displays a number of carrier-mediated and vesicular transport systems found in the intestine in vivo, and is thus providing a useful system for studying the intestinal transport of drugs including peptides and proteins.

Biological Transport↗
PubMedDate not supplied

A technetium-99m red cell survival technique for in vivo compatibility testing.

A technique for labeling red cells with Technetium-99m was developed using in vitro reduction by stannous pyrophosphate. The use of Technetium-99m and Chromium-51 enabled simultaneous determination of 60-minute autologous and heterologous red cell survival using small aliquots. In vivo pretransfusion red cell compatibility in a patient with a panagglutinin was identical to that with 51Cr-labeled cells. Simultaneous testing of two heterologous donor units or testing multiple units in the course of a few days was also feasible. In nine studies (one patient and six healthy controls) no significant elution of the 99mTc was observed over 1 hour.

Aged↗
PubMedDate not supplied

Children with word-finding difficulties--prevalence, presentation and naming problems.

There is increasing interest from therapists and researchers in children's word-finding difficulties (WFDs). Word finding difficulties are usually considered to be present when children are able to identify a referent from a set of exemplars, but have difficulty producing the target word when shown a picture or in conversation. Word finding difficulties are associated with a number of conversational forms such as delays in the production of a word, the use of long pauses within phrases, frequent use of place holders ('uh', 'um', etc.) and the use of circumlocutions. Although interest is being shown in WFDs, most of the data come from relatively small samples with the result that one knows little about the prevalence of the condition, what circumstances exacerbate the condition, the occurrence of associated difficulties and the types of therapy that are employed. To obtain this information a survey was carried out in the South-East of England of practitioners working with children who have language difficulties. Twenty-three per cent of children in language support services were identified as having WFDs. Most respondents used a mixture of formal and informal assessments. It was reported that WFDs were associated with difficulties in grammatical production, word meaning and grammatical comprehension. WFDs in addition were more likely to occur in situations with high processing demands. A variety of intervention strategies were identified. These findings are discussed in relation to current practice and the authors understanding of the condition.

Adolescent↗
PubMedDate not supplied

In vivo barium microangiography in the mouse.

Barium microangiography is an accepted method for study of the microcirculation. Nonetheless, no method has been previously described for use in mouse models of renal microangiopathy. Using a midline abdominal approach on each of seven anesthetized A/J mice, we inserted a No. 27 lymphangiogram needle into the infrarenal aorta. Using a Harvard pump, the animals were perfused first with 20 ml of 1% glutaraldehyde, then 20 ml of 10% barium sulfate suspension, at 150 mmHg constant pressure. Kidney sections were radiographed onto high-resolution glass plates. Photomicrographs of these images were then enlarged to 5 x 7-inch prints, from which we derived our observations. We observed the normal branching pattern of the renal microcirculation. Mean interlobular artery diameter was 31.89 +/- 2.12 micron SD. Afferent arterioles tapered to a mean preglomerular diameter of 13.55 +/- 1.64 micron. Mean glomerular area was measured to be 2945 +/- 233 sq micron. We have developed a method of renal barium microangiography in the mouse. Desirable features of the technique include its performance on living animals and resolution sufficient to permit objective measurements of microvascular structures.

Angiography↗
PubMedDate not supplied

Recovery from decompensated non-insulin-dependent diabetes mellitus: studies of C-peptide secretion.

Eleven non-insulin-dependent diabetic patients presented with decompensated hyperglycemia. Nine had pronounced ketonuria, five with acidosis. In seven cases, precipitating factors were identified. In the other four cases, including three cases of diabetic ketoacidosis, no identifiable triggering events were present. In each case, recovery from the initially decompensated diabetic state occurred. Eventually, all patients were managed by diet alone. Seven patients demonstrated nondiabetic glucose tolerance tests (GTT). Several patients underwent stressful situations after "recovery" without recurrence of hyperglycemia. Glucose-stimulated C-peptide levels were determined postrecovery. C-peptide secretion was in the normal range and, in fact, was identical, in relation to glucose levels, to that in a group of nondiabetic volunteers. In 6 of the 11 cases, C-peptide secretion was measured at the time of initial presentation. These levels were markedly lower than comparable values during the GTT postrecovery. Non-insulin-dependent diabetes, even when presenting in a decompensated state, is subject to a considerable degree of reversibility and even recovery to a nondiabetic state in some cases. Recovery is associated with a return to normal C-peptide secretion.

Adult↗
PubMedDate not supplied

Atopic dermatitis and food hypersensitivity in children.

Atopic dermatitis is a common condition of early childhood. The association of atopic dermatitis and allergy has been studied for several years. Recent work has shown that food hypersensitivity does play a role as an exacerbating factor in some children with atopic dermatitis. This hypersensitivity will be limited typically to one or two food antigens. Children placed on appropriate elimination diets can be expected to have significant improvement in their clinical course.

Child↗