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Biomedical subjects

G Whyte

Publications and source records attributed to G Whyte.

41 records · Page 3Linked to original sources
PubMed1985

Assessment of HTLV III screening tests in Christchurch.

The Christchurch Hospital blood bank has assessed commercial kits designed to test blood donations for the presence of antibody to the retrovirus responsible for acquired immune deficiency syndrome (AIDS). Twenty of 1002 blood donations have been found to be repeatably, positive by one or more of these commercial kits. None was positive by the Western blot technique. Certain patient groups were found to have an elevated number of false positive reactions. Extreme caution is advised when interpreting screening test kit results from donor populations at low risk of AIDS.

Acquired Immunodeficiency Syndrome↗
PubMed1985

Blood donors of the Canterbury regional blood transfusion service.

A study of 1262 city blood donors showed that they are significantly different from the urban population eligible to donate. City blood donors are youthful and live in middleclass suburbs, donating in relation to work. Men predominate (1.3:1) and donate for longer than women. Young women donate blood readily but often discontinue in their late twenties, whereas in the country, women predominate (1.3:1), and continue giving into their forties. Recruited city donors are frequently women in their thirties and forties. It is concluded that future city blood donor recruitment should be directed to suburban women in their thirties and forties.

Adolescent↗
PubMed1979

Severe deficiency of vitamin K dependent coagulation factors in an infant.

A severe deficiency of vitamin K dependent coagulation factors presenting 25 days after birth in an apparently healthy breast-fed infant is reported. The administration of antibiotics to the lactating mother, and lack of a vitamin K supplement to the new-born baby were possible predisposing factors.

Adult↗
PubMed1976

The cryopreservation of leukaemia cells: morphological and functional changes.

Stored autologous haemopoietic cells may be used to repopulate the bone marrow of patients in the advanced stages of different leukaemias who have received cytotoxic drugs. We have used a continuous flow blood cell separator to collect peripheral blood leucocytes from patients with chronic granulocytic leukaemia (CGL) before treatment. We also collected bone marrow cells from patients with CGL and from patients with acute myeloid leukaemia in complete remission. The collected cells were frozen at I degree C per minute using dimethyl sulphoxide as cryoprotective agent and stored in liquid nitrogen. For reconstitution of frozen cells we found that the use of dextran II0 inhibited leucoagglutination. The viability and function of the reconstituted leucocytes were assessed by their morphological appearance, their capacity to phagocytose and kill Candida albicans organisms, their ability to reduce the dye nitroblue tetrazolium (NBT) in vitro and to incorporate tritiated thymidine into DNA and by the growth of colony forming units (CFUc) in agar culture. With this method of cryopreservation the phagocytic function of mature neutrophils is retained to some extent but their capacity to reduce NBT and their microbicidal activity are completely lost. In contrast CFUc may remain after storage for periods of at least 2 years.

Bone Marrow↗