Biomedical subjects
G Wenzel
Publications and source records attributed to G Wenzel.
[Efficacy of experimental renal embolization with microspheres. Additionally, a critical report on the complication rate of intra-arterial embolization with particles (author's transl)].
Renal embolization was performed in 12 dogs using the Seldinger technique and microspheres 250 +/- 40 micrometer in diameter. Periodical arteriography, microangiographies and histological analysis was carried out to control the efficacy of embolization. As a result, renal arteries could be embolized wi. th microspheres, however, because of statistical distribution there were histologically anemic and normal parenchyma situated closely together. In more than 50% there was a reflux of microspheres which could only be detected by histological examination, while angiographies showed a totally normal vascular pattern. Microspheres should not be used in clinical embolization. Experimental investigation of embolization materials must almost embrace histological analysis.
[Permanent stop of renal circulation by embolisation with microspheres. Preliminary report (author's transl)].
The risk of tumor cell dislodgement during operative removal of carcinoma of the kidney is reduced by preoperative occlusion of the renal arteries. After the intraarterial injection of 250 mu microspheres a complete blockage of the intrarenal circulation was found in all three experimental animals for at least 2 hrs. In the other two dogs the blockage remained unchanged over 24 hrs. Subsequent experiments shall demonstrate that the simple embolisation technique using microspheres is more stable than other methods.