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Biomedical subjects

G Wellmitz

Publications and source records attributed to G Wellmitz.

At least 19 recordsLinked to original sources

The effect of brain fraction with fibroblast growth factor activity on regeneraton and differentiation of articular cartilage.

From bovine brains a fraction with fibroblast growth factor activity was prepared according to the method given by Gospodarowicz et al. (1978) and tested regarding to its biological effectiveness on articular cartilage regeneration in rabbits the cartilage in one knee-joint of those had been injured in a defined manner. The intraarticular administration of the brain fraction supported the healing process of the intrachondral lesions by conspicuously increasing the chondrocyte proliferation starting from preexisting cartilage tissue. In the case of subchondral lesions the neodifferentiation of chondrocytes out of the simple connective tissue that primarily filled the defect was promoted significantly.

Animals↗

A bovine brain fraction with fibroblast growth factor activity inducing articular cartilage regeneration in vivo.

A bovine brain fraction with fibroblast growth factor (FGF) activity was prepared according to the method described by Gospodarowicz et al. and its influence on the healing process of experimentally produced intrachondral lesions in the knee-joint of rabbits was studied. Intraarticular administration of this preparation resulted in a substantial stimulation of the proliferation of "cluster cells", a special kind of chondrocytes which accumulate and form clusters.

Animals↗

[Antepartal and intrapartal betamimetic long-time-therapy - effects on blood sugar in premature infants (author's transl)].

The glucose oxidase method was used to measure blood sugar concentrations of 61 newborns over their first 24 hours of life in an effort to study the effects of long-time antepartal and intrapartal application of betamimetics to the mothers upon the blood sugar levels of premature infants. Betamimetically affected premature infants, different from all expectation, exhibited a trend towards higher blood glucose values in the first hours from birth. However, no difference was any longer recordable between the treated group and the controls, after twelve hours had elapsed.

Blood Glucose↗