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Biomedical subjects

G Weisz

Publications and source records attributed to G Weisz.

53 records · Page 3Linked to original sources
PubMed1984

Hepatic actions of progestogenic steroids.

The effects of two oral progestogens, norethisterone and d-norgestrel, were studied on hepatic functions in CFY female rats. In healthy animals both progestogens inhibited cytochrome-P-450 dependent nonspecific mixed function monooxygenases. Serum bilirubin and cholylglycin RIA values were normal. Protein and glycogen content of the liver remained intact after norethisterone, d-norgestrel reduced glycogen. The pathologic values characteristic for chronic carbon-tetrachloride damage improved on a highly significant grade when these progestogens were simultaneously administered. The progestogens inhibited mixed function monooxygenases. We may presume that in this way they inhibited the formation of hepatotoxic trichloromethyl free radical and improved several liver functions.

Aminopyrine N-Demethylase↗
PubMed1983

Serum alpha-fetoprotein in chronic liver disease.

The serum alpha-fetoprotein level was measured by radioimmunoassay in 20 normal subjects and in 118 patients with chronic liver disease. The highest concentrations were found in the group of hepatocellular carcinoma. Compared with the controls, higher values were demonstrable in the other groups of liver disease as well. This is attributed to the more or less marked regeneration of liver tissue, which is never absent in any type of liver disease studied, and in the case of fatty degeneration, to the alpha-fetoprotein inducing effect of alcohol. The importance of alpha-fetoprotein estimation in the diagnosis of hepatocellular carcinoma and monitoring of its therapy, as also in the assessment of activity and regeneration in other forms of chronic liver disease, are pointed out. Countercurrent electrophoresis has been found unreliable for the measurement of alpha-fetoprotein.

Adult↗
PubMed1981

Dimensions of intimacy in marriage.

Intimacy as an important aspect of interpersonal relationships has been widely accepted (Erikson 1950, Sullivan 1953). In the broad context, an understanding of the role of intimacy has been discussed as essential to the development of a science of interpersonal relationships (Hinde 1978). More specifically, intimacy has been cited as an important dimension of the marital interpersonal relationship (Berman and Lief 1975). This paper describes a study of intimacy in 30 young married couples, randomly selected from the general population. Personal identity and accurate perception of the spouse were significant correlates of marital intimacy, and a factor analysis revealed four dimensions of marital relationships: compatibility, structure, intimacy, and problem-solving. In this study, marital adjustment was significantly correlated with expressiveness, commitment, organization, expressed affection, and the absence of conflict. These findings are discussed in the context of the role of intimacy in a science of interpersonal behavior.

Adolescent↗
PubMed1980

Concepts of intimacy in the general population.

A random sample of 50 adults in the general population received an open ended interview regarding their concepts of intimacy. A second random sample of 24 couples from the general population and 24 clinical couples received a standardized interview in which concepts of intimacy were systematically rated to develop an operational definition of the dimensions of intimacy. Self-disclosure was identified as a fundamental aspect of intimacy in interpersonal relationships and marriage. Expression of affection, compatibility, cohesion, identity, and the ability to resolve conflict were also considered important aspects of intimacy. Sexual satisfaction was considered less important than previous definitions of intimacy have suggested. The perception of his or her parents' level of intimacy was thought to influence the subject's own interpersonal relationships. Couples with marital maladjustment and/or psychiatric illness were less aware of aspects of their marriage which influence intimacy. They more frequently disagreed that sexuality influenced their level of intimacy. The study suggests that self-disclosure and parental interpersonal intimacy may be fundamental factors in marital adjustment which merit further research.

Adult↗
PubMed1979

Lysozyme catalysis: kinetics of the hydrolysis of cell wall oligosaccharides.

The cleavage of cell wall tetrasaccharide, the beta(1 leads to 4)-linked dimer of the basic repeating disaccharide N-acetyl-D-glucosamine-beta(1 leads to 4)-N-acetyl-D-muramic acid, by lysozyme has been studied at various concentrations of lysozyme and over long time ranges. A theoretical analysis of the kinetic results indicates that direct hydrolysis of the tetrasaccharide by binding in subsities CDEF of the active site of lysozyme is significant at long times relative to the transglycosylation pathway. The binding constant for tetrasaccharide in CDEF is shown to be 10(3) times larger than that determined on the basis of an analysis of kinetic data over a more restricted range of times and concentrations.

Binding Sites↗
PubMed1978

The nuclear magnetic resonance determination of the conformation of saccharides bound in subsite D of lysozyme.

The binding of the trisaccharide (2-acetamido-2-deoxy-D-muramic acid)-beta(1 leads to 4)-(2-aceta-mido-2-deoxy-D-glucosyl)-beta(1 leads to 4)-(2-acetamido-2-deoxy-D-muramic acid) to subsites B, C, and D in lysozyme has been studied by 1H nuclear magnetic resonance methods. In particular, the coupling constant between H1 and H2 of the reducing saccharide bound in subsite D has been determined. The coupling constant for the bound saccharide indicates that the dihedral angle between C1 and C2 for the reducing saccharide is not significantly changed upon binding to lysozyme. This result is discussed in terms of other evidence for the role of distortion of the saccharide bound in subsite D in the lysozyme-catalyzed hydrolysis of cell wall oligosaccharides.

Binding Sites↗
PubMedDate not supplied

Oral magnesium intake reduces permanent hearing loss induced by noise exposure.

INTRODUCTION: Following animal experiments where correlations were observed between serum magnesium level and noise-induced permanent hearing threshold shifts (NIPTS), we tested the prophylactic effect of magnesium in human subjects exposed to hazardous noise. METHODS: Subjects were 300 young, healthy, and normal-hearing recruits who underwent 2 months of basic military training. This training necessarily included repeated exposures to high levels of impulse noises while using ear plugs. During this placebo-controlled, double-blind study, each subject received daily an additional drink containing either 6.7 mmol (167 mg) magnesium aspartate or a similar quantity of placebo (Na-aspartate). RESULTS: NIPTS was significantly more frequent and more severe in the placebo group than in the magnesium group, especially in bilateral damages. NIPTS was negatively correlated to the magnesium content of blood red cells but especially to the magnesium mononuclear cells. Long-term additional intake of a small dose of oral magnesium was not accompanied by any notable side effect. CONCLUSION: This study may introduce a significant natural agent for the reduction of hearing damages in noise-exposed population.

Administration, Oral↗