Congenital anetoderma induced by intrauterine infection?
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Congenital Abnormalities↗
Biomedical subjects
G Weissenbacher
Publications and source records attributed to G Weissenbacher.
[Radiologic changes in metaphyseal chondrodystrophy of the McKusick type (cartilage-hair hypoplasia)].
A ten year old boy with parents of Rumanian and Turkish origin suffered from metaphyseal chondrodysplasia (McKusick type) with typical radiological changes of the metaphyseal endplates. Microscopic examination of his hair revealed only slight diminution of its thickness, and signs of increased brittleness. Because of Hirschsprung's disease resection of colon was performed. No immunologic changes were found.
Achondroplasia↗
[Combination aerosol for bronchial asthma in childhood].
40 children with clinical diagnosis of bronchial asthma aged 8--14 years, 39 with allergic disposition, were investigated. Acute therapeutic and protective effect on frequency of asthmatic attacks, pulmonary auscultation and lung function (FEV1, PF, FVC) by application of Fenoterol and Ipratropium as combination aerosol were registered. Over a period of 4 weeks we could reduce the frequency of attacks nearly to the half. 10 and 20 minutes after aerosol application we showed a good improvement of pulmonary ventilation. Only on children with severe asthma bronchiale an exclusive treatment with Berodual seems to be of modest protective effect.
Adolescent↗
[Neurological development screening of high risk infants in an Austrian provincial district (author's transl)].
This report describes the results of a systematic development screening of high risk infants in a provincial district over a period of three and a half years. Criteria for neurological research during the first year of life and organizing problems are presented. Low frequency of medical care during pregnancy seems to be a main factor predetermining cerebral palsy and multiple disabilities. An optimal transport system seems to be a supporting factor for the prevention of such motoric and mental derangements, especially in children, who initially show no pulmonary or cardiac problems.
Austria↗
Pulsatile secretion of gonadotropins in early infancy.
In adults, luteinizing hormone (LH) and follicle stimulating hormone (FSH) are secreted in a pulsatile manner. Prior to puberty gonadotropin (GN) levels are low and show only small fluctuations. The following investigation was performed to elucidate the type of GN secretion in infants. LH and FSH were determined every 30 min over a period of 8 h in three different groups: Group 1:2 male and 2 female adults; Groups 2:2 male and 2 female prepubertal children; Group 3:3 male and 3 female infants, aged 6-12 weeks. Group 1 showed a clear pulsatile secretion of LH (4.5-23.5 mIU/ml [range]) and FSH (6.9-16.0 mIU/ml). Group 2 demonstrated a rather constant secretion of LH (less than 1.5-2.3 mIU/ml) and FSH (1.6-4.9 mIU/ml). Group 3: In male infants pulsatile secretion of LH (3.6-34.7 mIU/ml)--and to a lesser degree of FSH (1.8-4.6 mIU/ml)--were found. In female infants the pulsatile secretion of FSH (6.5-22.7 mIU/ml) was more pronounced than that of LH (less than 1.5-4.7 mIU/ml). The secretory pattern in early infancy is of a pulsatile type.
Adult↗
Symptomatology of the most severe form of tuberculous meningitis.
Seven cases of the most severe form of tuberculous meningitis, in which a midbrain syndrome developed, are reported. Three different types of progress were observed. Exudative inflammation and cerebral edema dominated in the first group, causing the rapid development of the acute midbrain syndrome, which may turn into a bulbar syndrome. In the second group the development of the midbrain was delayed and an apallic syndrome followed. The morphological examination disclosed local diencephalic and midbrain lesions caused by herniation and specific vasculitis and vascular compression. The third group showed disintegration of cortical function as a result of parenchymal lesions, apart from local midbrain symptoms which never fully intensified into the midbrain syndrome. Observation of the progress of the disease proved that late diagnosis and delayed therapy were decisive in cases of the most severe form of tuberculous meningitis.
Adolescent↗
Urinary excretion of glomerular basement membrane antigens in Alport's syndrome. A new diagnostic approach.
Alport's syndrome is defined by the combination of hereditary nephropathy and neurosensory deafness, and is diagnosed from the family history combined with renal electron microscopy. Immunoelectrophoresis of the urine of 8 of 12 children suspected of Alport's syndrome showed a precipitation line moving into the beta-zone, applying an antiglomerular basement membrane antibody derived from an immunised rabbit. All patients who showed the typical pattern of Alport's syndrome on renal electron microscopy were among the 8 cases whose urine gave this immunoelectrophoresis pattern. Additionally, 5 of the mothers of the 8 children excreted the same antigen in their urine. The urine of 30 healthy children and of 10 patients with the idiopathic nephrotic syndrome did not show the presence of this antigen. This characteristic sign of Alport's syndrome may therefore be useful for its detection.
Adolescent↗
[Hemodialysis in children (author's transl)].
Long term hemodialysis and kidney transplantation has proved to be a very efficient method in the treatment of renal failure in childhood. Accordingly, the number of children treated by dialysis and transplantation in Europe is still increasing. At this time more than 1250 have been treated. As a result of recent studies, one to two children under the age of 15 years per one million population per one year reach the terminal stage of renal insufficiency. We performed our own informative study in 1975 to estimate the needs for dialysis facilities in Austria. Our results are in line with those of other projects. In view of the special childhood problems (growth, puberty, psychological problems, schooling etc.) there is a need for specialized pediatric centers which should include the facilities for nephrologic out- and in-patient treatment, a dialysis team consisting of a pediatrician, pediatric nurses, teacher, child psychologist, dietician and social worker. These enormous investments in apparature, personnel and organization are justified by the good results of survival and the reasonably normal life these children can lead.
Acute Kidney Injury↗
[Alpha-2-macroglobulin in children with glomerular diseases (author's transl)].
The serum and urine levels of alpha-2-macroglobulin (alpha2-MG) was determined in 33 children with glomerular diseases and in 26 healthy control children. Healthy children showed a minimum level of 275 mg% and maximum level of 337 mg%, with a mean concentration of 301 mg% and a standard deviation of 13 mg%. No alpha2-MG was detected in the urine. Steroid-treated patients with idiopathic nephrotic syndrome displayed elevated inhibitor levels of up to 490 mg%. This might be a direct result of steroid therapy or a consequence of reactively-increased protein synthesis in response to the renal protein loss. In all these patients the urine was found to be alpha2-MG-negative, irrespective of the presence or absence of proteinuria. In the miscellaneous group of glomerulopathies without the nephrotic syndrome, serum levels of alpha2-MG were shown to be normal. The urinary concentrations of alpha2-MG were related to the activity of the disease. alpha2-MG determination in serum and urine seems to be a tool for differential diagnosis and prognosis in some cases of glomerular disease.
Acidosis, Renal Tubular↗
[Calcification of the urinary bladder, a rare finding in the newborn (author's transl)].
The rare X-ray finding of urinary bladder wall calcifications in a newborn is reported. The newborn suffered from micturition disturbance caused by urethral valves, bilateral hydroureter and bilateral hydronephrosis. No possible definite cause for the calcification of the bladder wall could be found. The calcifications could never be detected by X-ray after the age of 5 months.
Calcinosis↗
[Alpha-1-antitrypsin in children with glomerular diseases (author's transl)].
Alpha-1-antitrypsin was determined in children with glomerular diseases by means of a quantitative radial immunodiffusion method. The concentration of this inhibiting protein has been found to be very low during relapses. An attempt has been made to correlate this finding with the clinical picture and the presumed underlying pathological mechanism. The loss of this inhibitor due to proteinuria is one of the explanations, in concurrence with the findings of other authors. The second explanation lies in the consumption of the inhibitor protein as a consequence of the reaction with liberated proteolytic enzymes.
Adolescent↗
[Renal transplantation in children (author's transl)].
During the past 2 years 7 children received kidneys from cadaveric donors. 2 transplants had to be removed because of irreversible chronic rejection and 1 recipient died on the 4th day after surgery. The remaining 4 recipients are doing well. In the evaluation of the results special emphasis is placed on the normalization of growth and puberty. The difficulties of psychosocial rehabilitation are stressed.
Adolescent↗
[The presence of cold agglutinins in hemolytic uremic syndrome (author's transl)].
A boy, 2 years old, developed a HUS after a pneumonitis. He was treated with Heparin, salicylates and recurrent peritoneal dialysis and recovered slowly. The course of the disease was complicated by myocarditis, gastric hemorrhage and severe neurologic disturbances. 7 days after unset of hemolysis a cold agglutinin titer of 1:256 was detected. This fact arises the question whether infection with Mycoplasma pneumoniae and the presence of cold agglutinins in serum could be involved in the development of HUS. The possibility of a viral etiology for this disease is discussed.
Agglutinins↗
[Metabolic alkalosis and secondary hyperaldosteronism in cystic fibrosis (author's transl)].
The prolonged use of a salt restricted infant formula (1.9 mEq Na/kg/day and 1,4 mEq C1/kg/day) in a child with undiagnosed cystic fibrosis led to a life threatening metabolic disturbance. The main features were hypochloraemic alkalosis due to massive loss of electrolytes in the sweat. Urinary electrolyte excretion, however, had been lowered to a minimum due to aldosteron induced reabsorption. Plasma aldosterone levels were initially high, but returned to normal after addition of salt to the feeds. Prior to admission a sweat test had been negative. The patient clearly demonstrates the unique metabolic feature of cystic fibrosis of the ability to retain electrolytes in the tubulus and at the same time the inability of the sweat glands to reabsorb sodium and chloride. Contrary to present experience severe prolonged salt restriction is believed to be able to diminish sweat electrolytes to subpathological values.
Aldosterone↗
[Aerophagia - case history and differential diagnosis (author's transl)].
Meteorism is a nonspecific symptom and it is difficult to exclude organic causes. In one of our patients, a 6 years old girl, the accumulation of gas had caused changes of the normal abdominal situs. Finally psychogenic aerophagia could be detected by exact analysis of the case history and the daily rhythm of meteorism. The situation within the family could be revealed as trigger mechanism and there an successful therapy was started.
Abdomen↗
[Unviable micromelic dwarfism: a syndrome with dystrophy of the thorax and polydaktyly type Saldino-Noonan (author's transl)].
Besides classical achondroplasia various severe osteochondrodysplastic disorders have been differentiated in recent years. Their most important features include obligatory perinatal mortality, severe dystrophy of the thorax and shortening of tubular bones. Additionally some of these syndromes present visceral malformations, cleft-lip, and malformations of the genitals. A detailed case report of a patient is given. Various features: dystrophy of the thorax, micromelia, postaxial polydactyly, metaphyseal dysplasia, malformations of the great vessels, and polcystic kidney suggest the classification as short rib-polydactyly syndrome, type Saldino-Noonan.
Aorta↗
[Combination of the syndrome of Sturge-Weber and the syndrome of Klippel-Trénaunay (author's transl)].
Up until now 39 cases of combined Klippel-Trénaunay syndrome and Sturge-Weber syndrome have been described. Here follows the report of a girl, now 4 years of age, displaying a full combination of these syndromes. Only a small part of the body surface is not covered with naevi teleangiectatici laterales. The patient has clear hypertrophy of the left cheek and of the left lower extremity, less noticeable on the left upper extremity. For therapeutic reasons the left side of the head and the left lower extremity were thoroughly angiographically examined--this revealed typical abnormalities. The vessel-alteration of the lower extremity are not extremely far developed and arteriovenous fistulas on a large scale are also absent. This allows us to dismiss the F.P. Weber syndrome on the one hand, while it explains the absence of complications of the Klippel-Trénaunay syndrome, as described in literature, on the other. The significance of the alterations of lymph nodes in this disease, which we are the first to describe, is at present not fully clear. The cerebral attacks have until now showed only a temporary response to medication.
Angiography↗
[Alport's-syndrome: diagnosis, light- and electronmicroscopic findings (author's transl)].
Alport's syndrome is a hereditary nephropathy with grave prognostic consequences. The occurrence of this disease is probably more frequent than was assumed until now - many cases are not immediately recognized as such. It is possible to make a clinical diagnosis from detailed family histories and through careful examinations of family members including audiometric tests. In the early stages of the disease children merely have recurrent macro- or microhematuria. Renal functional tests are normal and there is general well-being of the patient. Whereas the biopsy specimens examined by light microscopy show non-specific alterations, those examined under the electronmicroscope already show specific defects of the basement membrane. Our studies lead us to believe that these morphologic findings correspond with changes of the basement membrane, detectable by immunochemical investigations. 6 of 12 patients have been biopsied in recent time and the above cited typical changes of the basement membrane could be demonstrated. Therefore these investigations are recommended in Alport's syndrome.
Adolescent↗